Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Sophia, Tsoka"'
Autor:
Robert O’Shea, Thubeena Manickavasagar, Carolyn Horst, Daniel Hughes, James Cusack, Sophia Tsoka, Gary Cook, Vicky Goh
Publikováno v:
Insights into Imaging, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Purpose Interpretability is essential for reliable convolutional neural network (CNN) image classifiers in radiological applications. We describe a weakly supervised segmentation model that learns to delineate the target object, trained with
Externí odkaz:
https://doaj.org/article/88c309b7ddd141859854a072a239de8b
Autor:
Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N. Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J. Harris, Silvia Mele, Giulia Pellizzari, Anna B. M. Black, Heather J. Bax, Anthony Cheung, Mano Nakamura, Ricarda M. Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K. Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K. Dunn-Walters, Eleftherios P. Diamandis, Sophia Tsoka, James Spicer, Katie E. Lacy, Franca Fraternali, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail. Here we show comprehensive phenotyping in sampl
Externí odkaz:
https://doaj.org/article/ec79417fc51f4749a49432bb35eb4eff
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Autor:
Prudence PokWai Lui, Chrysanthi Ainali, Chung-Ching Chu, Manuela Terranova-Barberio, Panagiotis Karagiannis, Angela Tewari, Niloufar Safinia, Ehsan Sharif-Paghaleh, Sophia Tsoka, Grzegorz Woszczek, Paola Di Meglio, Giovanna Lombardi, Antony R. Young, Frank O. Nestle, Niwa Ali
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108029- (2023)
Summary: Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified CD141+CD14+ DDCs as a skin-resident immunoregulatory populati
Externí odkaz:
https://doaj.org/article/bfb8903d33a541d1b9febee12c9327fb
Publikováno v:
Insights into Imaging, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Objectives Radiomic models present an avenue to improve oesophageal adenocarcinoma assessment through quantitative medical image analysis. However, model selection is complicated by the abundance of available predictors and the uncertainty o
Externí odkaz:
https://doaj.org/article/d77d096dc7e245cfb3a39e1a401a87e4
Autor:
Friedrich Haag, Carsten Bokemeyer, Lars Bullinger, Franziska Brauneck, Brit Fischer, Marius Witt, Jana Muschhammer, Jennyfer Oelrich, Pedro Henrique da Costa Avelar, Sophia Tsoka, Elisa Seubert, Daniel J Smit, Christin Ackermann, Jasmin Wellbrock, Walter Fiedler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Leukemia-associated macrophages (LAMs) represent an important cell population within the tumor microenvironment, but little is known about the phenotype, function, and plasticity of these cells. The present study provides an extensive char
Externí odkaz:
https://doaj.org/article/2e7533273bea4d89a9f1519e8d362800
Autor:
Robert J Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L. C. Geh, Alastair D MacKenzie Ross, Ciaran Healy, Sophia Tsoka, James Spicer, Katie E Lacy, Sophia N Karagiannis
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in patients with melanoma by flow cytometric intracellular cytokine, CyTOF, transcriptomic, immun
Externí odkaz:
https://doaj.org/article/5ee960605c5a4a89bebd0943b4e44eca
Autor:
Rebecca Adams, Gabriel Osborn, Bipashna Mukhia, Roman Laddach, Zena Willsmore, Alicia Chenoweth, Jenny L C Geh, Alastair D MacKenzie Ross, Ciaran Healy, Linda Barber, Sophia Tsoka, Victoria Sanz-Moreno, Katie E Lacy, Sophia N Karagiannis
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The application of monoclonal antibodies (mAbs) for the treatment of melanoma has significantly improved the clinical management of this malignancy over the last decade. Currently approved mAbs for melanoma enhance T cell effector immune responses by
Externí odkaz:
https://doaj.org/article/96ec4ae35e51463cbf1b5510ddb115e2
Autor:
Pedro Henrique da Costa Avelar, Natalia del Coco, Luis C. Lamb, Sophia Tsoka, Jonathan Cardoso-Silva
Publikováno v:
Healthcare Analytics, Vol 2, Iss , Pp 100115- (2022)
Following the outbreak of the coronavirus epidemic in early 2020, municipalities, regional governments and policymakers worldwide had to plan their Non-Pharmaceutical Interventions (NPIs) amidst a scenario of great uncertainty. At this early stage of
Externí odkaz:
https://doaj.org/article/6112f0027f6845c6a299653ad4da0f41
Publikováno v:
Cancer Informatics, Vol 20 (2021)
Background: Evaluation of gene interaction models in cancer genomics is challenging, as the true distribution is uncertain. Previous analyses have benchmarked models using synthetic data or databases of experimentally verified interactions – approa
Externí odkaz:
https://doaj.org/article/d2c6613ebad14b04be7cce97ef0de93f