Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sophia, Lai"'
Autor:
Donghyun Lim, Qingxuan Zhou, Kurt J. Cox, Benjamin K. Law, Miseon Lee, Praveen Kokkonda, Vedagopuram Sreekanth, Rajaiah Pergu, Santosh K. Chaudhary, Soumyashree A. Gangopadhyay, Basudeb Maji, Sophia Lai, Yuka Amako, David B. Thompson, Hari K. K. Subramanian, Michael F. Mesleh, Vlado Dančík, Paul A. Clemons, Bridget K. Wagner, Christina M. Woo, George M. Church, Amit Choudhary
Publikováno v:
Nat Cell Biol
The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present are not generalizable to multiple nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fc6b03b4a9c93d1ffd988021f853ba
https://doi.org/10.1038/s41556-022-01005-8
https://doi.org/10.1038/s41556-022-01005-8
Publikováno v:
Protein Homeostasis in Drug Discovery. :419-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a02cea01a544eb7568694c2de28884
https://doi.org/10.1002/9781119774198.ch12
https://doi.org/10.1002/9781119774198.ch12
Publikováno v:
The Journal of Alternative and Complementary Medicine. 27:796-802
Objective: To characterize dietary supplements marketed online as “ephedra-containing or ephedra-like products” for weight management and to assess labeling/marketing compliance with the ban on the...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3088c450960b6ff0772ab6f0cfa77fc6
https://doi.org/10.1089/acm.2021.0016
https://doi.org/10.1089/acm.2021.0016
Publikováno v:
Cell Chemical Biology. 28:1081-1089
Nature takes advantage of induced proximity to perform various functions. Taking inspiration from nature, we can also trigger desired biological processes using bifunctional small molecules that artificially induce proximity. For example, bifunctiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681c758ab0fdd67c458178b0813427a5
https://doi.org/10.1016/j.chembiol.2021.06.005
https://doi.org/10.1016/j.chembiol.2021.06.005
Autor:
Max Jan, David R. Liu, Arghya Deb, Vedagopuram Sreekanth, Praveen Kokkonda, Veronika Shoba, Santosh K. Chaudhary, Benjamin L. Ebert, Jaron A. M. Mercer, Praveen K. Tiwari, Amit Choudhary, Sophia Lai, Tuan M. Nguyen
Proteolysis Targeting Chimeras (PROTACs), a class of heterobifunctional molecules that recruit target proteins to E3 ligases, have gained traction for targeted protein degradation. However, pomalidomide, a widely used E3 ligase recruiter in PROTACs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af392a53b6a8e1f2ea031a468ca70edc
https://doi.org/10.1101/2021.11.18.468552
https://doi.org/10.1101/2021.11.18.468552
Publikováno v:
Journal of alternative and complementary medicine (New York, N.Y.). 27(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8860ab9f922fe4e0aeb83ec1dbb08d8e
https://pubmed.ncbi.nlm.nih.gov/33979529
https://pubmed.ncbi.nlm.nih.gov/33979529
Autor:
Stuart L. Schreiber, Veronika Shoba, Peng Wu, Sachini U. Siriwardena, Mengchao Shi, Sophia Lai, Dhanushka N P Munkanatta Godage, Santosh K. Chaudhary, Amit Choudhary
Publikováno v:
Journal of the American Chemical Society. 142(33)
Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via proximity-mediated effect are emerging. Phosphorylation (native or neo) of any given protein-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6b4909767e75e16a6ba971ae291a5b
https://pubmed.ncbi.nlm.nih.gov/32787262
https://pubmed.ncbi.nlm.nih.gov/32787262
Publikováno v:
International Journal of Clinical Pharmacy. 39:831-835
Background According to drug interaction databases, torsemide may potentiate the effects of warfarin. Evidence for this drug-drug interaction, however, is conflicting and the clinical significance is unknown. Objective The aim of this study is to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d302b98b0cac93f3733d9d8885840f
https://doi.org/10.1007/s11096-017-0479-6
https://doi.org/10.1007/s11096-017-0479-6
Autor:
Michael Naguib, Yury Gogotsi, M. Parans Paranthaman, Matthew Rager, Tomonori Saito, Meng-Qiang Zhao, Sophia Lai, Tolga Aytug
Publikováno v:
RSC Advances. 6:72069-72073
Herein we report on the synthesis and characterization of MXene–polyacrylamide (PAM) nanocomposite films. Dimethylsulfoxide intercalation in-between the Ti3C2-based MXene layers led to full delamination of the MXene layers and hence a uniform dispe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::306199631a800042804ea5f4b108b277
https://doi.org/10.1039/c6ra10384g
https://doi.org/10.1039/c6ra10384g
Autor:
Mary Liu, Dang M Tran, Tina Harrach Denetclaw, Andrew C. Faust, Catherine Lo, Lyndsay Sheperd, Sophia Lai
Publikováno v:
Journal of pharmacy practice. 31(1)
Objective: To report 2 cases of nonoperable intracranial bleeding associated with apixaban managed by 3-factor prothrombin complex concentrate (PCC3). Case Summaries: Case 1 presented with a 1.3-cm left parieto-occipital hemorrhage and a thin subdura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48fb28568cea5283e3f18e3d3ed936c
https://pubmed.ncbi.nlm.nih.gov/29278991
https://pubmed.ncbi.nlm.nih.gov/29278991