Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sophia, Khom"'
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106590- (2024)
The infralimbic cortex (IL) is part of the medial prefrontal cortex (mPFC), exerting top-down control over structures that are critically involved in the development of alcohol use disorder (AUD). Activity of the IL is tightly controlled by γ-aminob
Externí odkaz:
https://doaj.org/article/63f09a3222e341adab5fcc9c5ccfc5f3
Autor:
Sophia Khom, Vittoria Borgonetti, Valentina Vozella, Dean Kirson, Larry Rodriguez, Pauravi Gandhi, Paula Cristina Bianchi, Angela Snyder, Roman Vlkolinsky, Michal Bajo, Christopher S. Oleata, Roberto Ciccocioppo, Marisa Roberto
Publikováno v:
Neurobiology of Stress, Vol 25, Iss , Pp 100547- (2023)
Impairments in the function of the hypothalamic-pituitary-adrenal (HPA) axis and enhanced glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms in the pathogenesis of alcohol use disorder (AUD). The GR antagonist
Externí odkaz:
https://doaj.org/article/99beeb65eecb434d88af1339ae38c64f
Autor:
Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L. Pince, Sophie K. Elvig, Roman Vlkolinsky, Renata C.N. Marchette, George F. Koob, Marisa Roberto, Leandro F. Vendruscolo, Lorenzo Leggio
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the treatment of alcohol use disorder (AUD). Here, we examined the effects of semag
Externí odkaz:
https://doaj.org/article/765809f41835482da1b03fd08c62a8c7
Autor:
Vittoria Borgonetti, Bryan Cruz, Valentina Vozella, Sophia Khom, Michael Q. Steinman, Ryan Bullard, Shannon D’Ambrosio, Christopher S. Oleata, Roman Vlkolinsky, Michal Bajo, Eric P. Zorrilla, Dean Kirson, Marisa Roberto
Publikováno v:
Cells, Vol 12, Iss 15, p 1943 (2023)
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share dysregulated neuroimmune-related pathways. Here, we used our established rat model of comorbid post-traumatic stress disorder (PTSD)/AUD to characterize the interleuki
Externí odkaz:
https://doaj.org/article/f1ca53bbecf847929d0a2eb987ed9032
Autor:
Sophia Khom, Larry Rodriguez, Pauravi Gandhi, Dean Kirson, Michal Bajo, Christopher S. Oleata, Leandro F. Vendruscolo, Barbara J. Mason, Marisa Roberto
Publikováno v:
Neurobiology of Disease, Vol 164, Iss , Pp 105610- (2022)
Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in dependent rats are associated with increased GR signaling and changes in GR
Externí odkaz:
https://doaj.org/article/3609dd49c37d4a49bd8fa7e78acfae86
Autor:
Sophia Khom, Jacques D. Nguyen, Sophia A. Vandewater, Yanabel Grant, Marisa Roberto, Michael A. Taffe
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Male rats escalate intravenous self-administration of entactogen psychostimulants, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxymethamphetamine (MDMA) under extended access conditions, as with typical psychostimulants. Here, we i
Externí odkaz:
https://doaj.org/article/36af184a78654d53ae85a6e7649a6d58
Autor:
Florence P. Varodayan, Reesha R. Patel, Alessandra Matzeu, Sarah A. Wolfe, Dallece E. Curley, Sophia Khom, Pauravi J. Gandhi, Larry Rodriguez, Michal Bajo, Shannon D’Ambrosio, Hui Sun, Tony M. Kerr, Rueben A. Gonzales, Lorenzo Leggio, Luis A. Natividad, Carolina L. Haass-Koffler, Rémi Martin-Fardon, Marisa Roberto
Publikováno v:
Biol Psychiatry
BACKGROUND: Alcohol use disorder (AUD) is a leading preventable cause of death. The central amygdala (CeA) is a hub for stress and AUD, while dysfunction of the noradrenaline (NA) stress system is implicated in AUD relapse. METHODS: Here we investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4550499e0076c55ab4df29a54f31a8
https://doi.org/10.1016/j.biopsych.2022.02.006
https://doi.org/10.1016/j.biopsych.2022.02.006
Autor:
Dean Kirson, Sarah A. Wolfe, Larry Rodriguez, Michael Q. Steinman, Sophia Khom, Christopher S. Oleata, Marisa Roberto
Publikováno v:
Alcohol. 109:96-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b2edcf7e2f6f13118030b5ba2acbee
https://doi.org/10.1016/j.alcohol.2023.03.118
https://doi.org/10.1016/j.alcohol.2023.03.118
Autor:
Roman Vlkolinsky, Reesha R. Patel, Sarah A. Wolfe, Michal Bajo, Larry Rodriguez, Pauravi J Gandhi, Marisa Roberto, Dean Kirson, Florence P. Varodayan, Sophia Khom
Publikováno v:
Alcohol Alcohol
Aims Alcohol use disorder (AUD) is linked to hyperactivity of brain stress systems, leading to withdrawal states which drive relapse. AUD differs among the sexes, as men are more likely to have AUD than women, but women progress from casual use to bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0329bba12788d3893d4df58bf3750c
https://doi.org/10.1093/alcalc/agab034
https://doi.org/10.1093/alcalc/agab034
Autor:
Larry Rodriguez, Dean Kirson, Sarah A. Wolfe, Reesha R. Patel, Florence P. Varodayan, Angela E. Snyder, Pauravi J. Gandhi, Sophia Khom, Roman Vlkolinsky, Michal Bajo, Marisa Roberto
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7842
Alcohol use disorder (AUD) is a chronically relapsing disease characterized by loss of control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress systems. However, AUD differs among the sexes: men are more likely to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c503baa82e2eaa92c99a6b62f3a8e86
