Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sophia, Gunn"'
Autor:
Sophia Gunn, Xin Wang, Daniel C. Posner, Kelly Cho, Jennifer E. Huffman, Michael Gaziano, Peter W. Wilson, Yan V. Sun, Gina Peloso, Kathryn L. Lunetta
Publikováno v:
HGG Advances, Vol 6, Iss 1, Pp 100355- (2025)
Summary: Polygenic scores (PGSs) are a promising tool for estimating individual-level genetic risk of disease based on the results of genome-wide association studies (GWASs). However, their promise has yet to be fully realized because most currently
Externí odkaz:
https://doaj.org/article/b829f9f376e74e49ad8df3158c276dc3
Autor:
Sophia Gunn, Kathryn L Lunetta
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1011249 (2024)
Polygenic scores (PGS) are measures of genetic risk, derived from the results of genome wide association studies (GWAS). Previous work has proposed the coefficient of determination (R2) as an appropriate measure by which to compare PGS performance in
Externí odkaz:
https://doaj.org/article/9263817e96094042a345556e6ee16097
Autor:
Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Accurate classification of genetic variants is critical for research and patient care. Here, the authors report that population-based associations between rare variants and quantitative endophenotypes for monogenic diseases can provide support for va
Externí odkaz:
https://doaj.org/article/816988c3c3b240bbb3a8c919e46440d7
Autor:
Qingyan Xiang, Stacy L. Andersen, Benjamin Sweigart, Sophia Gunn, Marianne Nygaard, Thomas T. Perls, Paola Sebastiani
Publikováno v:
Journal of Alzheimer's Disease. :1-13
Background: Discovering patterns of cognitive domains and characterizing how these patterns associate with other risk factors and biomarkers can improve our understanding of the determinants of cognitive aging. Objective: To discover patterns of cogn
Autor:
Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/001990be3a844416bee130cfd57f4151
Autor:
Sophia Gunn, Michael Wainberg, Zeyuan Song, Stacy Andersen, Robert Boudreau, Mary F. Feitosa, Qihua Tan, May E. Montasser, Jeffrey R. O’Connell, Nathan Stitziel, Nathan Price, Thomas Perls, Nicholas J. Schork, Paola Sebastiani
Publikováno v:
GeroScience
A surprising and well-replicated result in genetic studies of human longevity is that centenarians appear to carry disease-associated variants in numbers similar to the general population. With the proliferation of large genome-wide association studi
Publikováno v:
Shock (Augusta, Ga.). 57(6)
The immunobiology defining the clinically apparent differences in response to sepsis remains unclear. We hypothesize that in murine models of sepsis we can identify phenotypes of sepsis using non-invasive physiologic parameters (NIPP) early after inf
Autor:
Victor Nauffal, Lu-Chen Weng, Timothy Treu, Sophia Gunn, Valerie N Morrill, Ashley Galloway, Shaan Khurshid, Darae Ko, Mark W Logue, Richard L Hauger, Kathryn L Lunetta, Jacob Joseph, Yan Sun, Emelia J Benjamin, Michael Gaziano, Kelly Cho, Peter Wilson, Patrick T Ellinor, Steven A Lubitz
Publikováno v:
Circulation. 144
Introduction: Observational studies have implicated atrial fibrillation (AF) as a risk factor for a number of cardiovascular diseases (CVD). Whether AF is causally related to these CVD is unknown. Methods: We included participants with both electroni
Autor:
Jennifer L, Halford, Valerie N, Morrill, Seung Hoan, Choi, Sean J, Jurgens, Giorgio, Melloni, Nicholas A, Marston, Lu-Chen, Weng, Victor, Nauffal, Amelia W, Hall, Sophia, Gunn, Christina A, Austin-Tse, James P, Pirruccello, Shaan, Khurshid, Heidi L, Rehm, Emelia J, Benjamin, Eric, Boerwinkle, Jennifer A, Brody, Adolfo, Correa, Brandon K, Fornwalt, Namrata, Gupta, Christopher M, Haggerty, Stephanie, Harris, Susan R, Heckbert, Charles C, Hong, Charles, Kooperberg, Henry J, Lin, Ruth J F, Loos, Braxton D, Mitchell, Alanna C, Morrison, Wendy, Post, Bruce M, Psaty, Susan, Redline, Kenneth M, Rice, Stephen S, Rich, Jerome I, Rotter, Peter F, Schnatz, Elsayed Z, Soliman, Nona, Sotoodehnia, Eugene K, Wong, Marc S, Sabatine, Christian T, Ruff, Kathryn L, Lunetta, Patrick T, Ellinor, Steven A, Lubitz
Publikováno v:
Nature communications, 13(1):5106. Nature Publishing Group
Accurate and efficient classification of variant pathogenicity is critical for research and clinical care. Using data from three large studies, we demonstrate that population-based associations between rare variants and quantitative endophenotypes fo
Autor:
Christian T. Ruff, Heidi L. Rehm, Wendy S. Post, Charles Kooperberg, Nicholas A Marston, Eric Boerwinkle, Peter F. Schnatz, Susan R. Heckbert, Kenneth Rice, Christopher M. Haggerty, Ruth J. F. Loos, Jennifer L. Halford, James P. Pirruccello, Stephanie L. Harris, Braxton D. Mitchell, Christina Austin-Tse, Shaan Khurshid, Victor Nauffal, Namrata Gupta, Susan Redline, Amelia W. Hall, Brandon K. Fornwalt, Nona Sotoodehnia, Elsayed Z. Soliman, Adolfo Correa, Marc S. Sabatine, Alanna C. Morrison, Sean J. Jurgens, Charles C. Hong, Lu-Chen Weng, Stephen S. Rich, Bruce M. Psaty, Steven A. Lubitz, Sophia Gunn, Seung Hoan Choi, Kathryn L. Lunetta, Jennifer A. Brody, Valerie N. Morrill, Eugene K. Wong, Jerome I. Rotter, Patrick T. Ellinor, Emelia J. Benjamin, Henry J. Lin, Giorgio E. M. Melloni
Accurate and efficient classification of variant pathogenicity is critical for research and clinical care. Using data from three large studies, we demonstrate that population-based associations between rare variants and quantitative endophenotypes fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438046267f02dda856a3d84ca173bffc
https://doi.org/10.1101/2021.08.28.21262571
https://doi.org/10.1101/2021.08.28.21262571