Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sophea Heng"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Embryo implantation is a key step in establishing pregnancy and a major limiting factor in IVF. Implantation requires a receptive endometrium but the mechanisms governing receptivity are not well understood. We have recently discovered that
Externí odkaz:
https://doaj.org/article/b03dad83eb3e4348a4c50168c70606f7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6210 (2022)
Development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Understanding the molecular regulation underpinning endometrial transformation to a receptive state is key to improving implantation rates
Externí odkaz:
https://doaj.org/article/a3e3433261a0482696e62b25222a0d28
Autor:
Huiting Ho, Harmeet Singh, Sophea Heng, Tracy L Nero, Sarah Paule, Michael W Parker, Alan T Johnson, Guan-Sheng Jiao, Guiying Nie
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81380 (2013)
Uterine proprotein convertase (PC) 6 plays a critical role in embryo implantation and is pivotal for pregnancy establishment. Inhibition of PC6 may provide a novel approach for the development of non-hormonal and female-controlled contraceptives. We
Externí odkaz:
https://doaj.org/article/66cb501266e04aa08ff0b13a107f6651
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45956 (2012)
Mammalian HtrA3 (high temperature requirement A3) is a serine protease of the HtrA family. It has two isoforms [long (HtrA3-L) and short (HtrA3-S)] and is important for placental development and cancer progression. Recently, HtrA3 was identified as a
Externí odkaz:
https://doaj.org/article/d3ce7569d8e145918d12198d9d7aa80e
Autor:
Bothidah Thach, Nirukshi Samarajeewa, Ying Li, Sophea Heng, Tesha Tsai, Mulyoto Pangestu, Sally Catt, Guiying Nie
Publikováno v:
Biology of Reproduction. 106:1143-1158
Podocalyxin (PODXL) is a newly identified key negative regulator of human endometrial receptivity, specifically down-regulated in the luminal epithelium at receptivity to permit embryo implantation. Here, we bioinformatically compared the molecular c
Publikováno v:
Molecular Human Reproduction. 28
Establishment of endometrial surface receptivity is crucial for the initiation of embryo implantation yet the molecular mechanisms are not well understood, especially in humans. We have recently discovered that podocalyxin (PODXL) is a critical negat
Autor:
Maxine Scelwyn, A. Aberkane, Luk Rombauts, Hilde Van De Velde, W. Essahib, M. Louise Hull, Sophea Heng, Beverley Vollenhoven, Nirukshi Samarajeewa, Guiying Nie
Publikováno v:
Fertility and sterility. 116(5)
Objective To study whether endometrial epithelial podocalyxin (PCX) inhibits implantation of human embryos in vitro and in patients undergoing in vitro fertilization (IVF). Design We have recently identified PCX as a key negative regulator of endomet
Autor:
Steven L. Young, Bruce A. Lessey, Sophea Heng, Maxine Scelwyn, Mary Mansilla, Thomas Nebl, Guiying Nie, M. Louise Hull, Beverley Vollenhoven, Ying Li, Rebecca Lim, Nirukshi Samarajeewa, Luk Rombauts, Sarah Grace Paule, Andrew I. Webb
Publikováno v:
Hum Reprod
STUDY QUESTION How is endometrial epithelial receptivity, particularly adhesiveness, regulated at the luminal epithelial surface for embryo implantation in the human? SUMMARY ANSWER Podocalyxin (PCX), a transmembrane protein, was identified as a key
Publikováno v:
Oncotarget
// Sophea Heng 1, 2, 3 , Jemma Evans 1, 2, 4 , Lois A. Salamonsen 1, 2, 4 , Tom W. Jobling 4, 5 and Guiying Nie 1, 2, 3 1 Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia 2 Department of Molecular and
Publikováno v:
Oncotarget
// Sophea Heng 1, 2, 3 , Andrew N. Stephens 2, 4, 6 , Tom W. Jobling 5, 6 , Guiying Nie 1, 2, 3 1 Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia 2