Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sooraj Achar"'
Autor:
Hannah W. Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A. Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P. Somerville, David F. Stroncek, Grégoire Altan-Bonnet, Nirali N. Shah, Christopher D. Chien, Naomi Taylor, Steven L. Highfill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101171- (2024)
Chimeric antigen receptor T cells (CART) have demonstrated curative potential for hematological malignancies, but the optimal manufacturing has not yet been determined and may differ across products. The first step, T cell selection, removes contamin
Externí odkaz:
https://doaj.org/article/e203f324125d46899b74298138fef026
Autor:
Shu Shien Chin, Erik Guillen, Laurent Chorro, Sooraj Achar, Karina Ng, Susanne Oberle, Francesca Alfei, Dietmar Zehn, Grégoire Altan-Bonnet, Fabien Delahaye, Grégoire Lauvau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The strength and duration of interleukin-2 (IL-2) signals is known to regulate T cell memory. Here the authors show that T cell receptor signalling strength controls the requirement for IL-2 signals to form CD8+ T cell memory with high functional act
Externí odkaz:
https://doaj.org/article/be0c9487ecc8454f9c2bdb6ecbd69bd9
Autor:
Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L. Wolters, Seth M. Steinberg, John A. Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Goldberg, Sooraj Achar, Dina Schneider, Shilpa A. Shahani, Lauren Little, Toni Foley, John C. Molina, Sandhya Panch, Crystal L. Mackall, Daniel W. Lee, Christopher D. Chien, Marie Pouzolles, Mark Ahlman, Constance M. Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Toledo-Tamula, Staci Martin, Steven L. Highfill, Gregoire Altan-Bonnet, David Stroncek, Terry J. Fry, Naomi Taylor, Nirali N. Shah
Publikováno v:
Blood. 140:451-463
Remission durability following single-antigen targeted chimeric antigen receptor (CAR) T-cells is limited by antigen modulation, which may be overcome with combinatorial targeting. Building upon our experiences targeting CD19 and CD22 in B-cell acute
Autor:
Taisuke Kondo, Justyn DuSold, Sooraj Achar, Serifat Adebola, Pedro Gonzalez-Menendes, Julie Perrault, Bonnie Yates, Hannah Song, Stephen Fox, Xia Xu, King Chan, Abdalla Abdelmaksoud, Christopher Chien, Marie Pouzolles, Haiying Qin, Steven Highfill, Thorkell Andresson, Nirali Shah, Valérie Dardalhon, Grégoire Altan-Bonnet, Naomi Taylor
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Erik Guillen, Shu Shien Chin, Laurent Chorro, Sooraj Achar, Karina Ng, Susanen Oberle, Francesca Alfei, Dietmar Zehn, Gregoire Altan-Bonnet, Fabien Delahaye, Gregoire Lauvau
Publikováno v:
The Journal of Immunology. 208:57.10-57.10
Priming of naïve CD8+ T cells requires three signals: 1) cognate antigen, 2) co-stimulation, and 3) cytokines. These signals orchestrate CD8+ T cell differentiation. Particularly, strong T cell receptor (TCR) signals induce a more robust effector re
Autor:
Shu Shien, Chin, Erik, Guillen, Laurent, Chorro, Sooraj, Achar, Karina, Ng, Susanne, Oberle, Francesca, Alfei, Dietmar, Zehn, Grégoire, Altan-Bonnet, Fabien, Delahaye, Grégoire, Lauvau
Publikováno v:
Nature communications. 13(1)
Cognate antigen signal controls CD8
Autor:
Sourish Ghosh, Teegan Dellibovi-Ragheb, Eowyn Pak, Qi Qiu, Matthew Fisher, Peter Takvorian, Christopher Bleck, Victor Hsu, Anthony Fehr, Stanley Perlman, Sooraj Achar, Marco Straus, Gary Whittaker, Xander de Haan, Gregoire Altan-Bonnet, Nihal Altan-Bonnet
Publikováno v:
SSRN Electronic Journal.
Autor:
Shu Shien Chin, Laurent Chorro, Sooraj Achar, Dietmar Zehn, Grergoire Altan-Bonnet, Fabien Delahaye, Gregoire Lauvau
Publikováno v:
The Journal of Immunology. 204:150.26-150.26
Previous studies established that TCR signaling strength determines the size of CD8+ T cell expansion and memory pool. Here we hypothesized that TCR signaling strength further modulates the functional features of memory CD8+ T cells. We immunized mic