Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Soophie Olfat"'
Autor:
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Eija Pirinen, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34355- (2024)
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD+ precursor nicotinamide riboside (NR) is a potential therapeutic for
Externí odkaz:
https://doaj.org/article/ac4f73d8f115461db81a3d5dd4a624da
Autor:
Heikki T. Virtanen, Peyman Choopanian, L. Lauriina Porokuokka, Richard Forsgård, Daniel R. Garton, Soophie Olfat, Riitta Korpela, Mehdi Mirzaie, Jaan-Olle Andressoo
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101405- (2024)
Background & Aims: The size and function of the enteric nervous system (ENS) can vary substantially between individuals. Because ENS function is involved in the etiology of a growing number of common human diseases, understanding mechanisms that regu
Externí odkaz:
https://doaj.org/article/5f463772172d48d79f00ab45dff8d6ea
Autor:
Kärt Mätlik, Soophie Olfat, Mark Cary Cowlishaw, Eva Domenech Moreno, Saara Ollila, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e13844- (2023)
The 3' untranslated regions (UTRs) modulate gene expression levels by regulating mRNA stability and translation. We previously showed that the replacement of the negative regulatory elements from the 3'UTR of glial cell line-derived neurotrophic fact
Externí odkaz:
https://doaj.org/article/484f94becc2c4485b2f14c38f96e9be8
Autor:
Kärt Mätlik, Daniel R. Garton, Ana R. Montaño-Rodríguez, Soophie Olfat, Feride Eren, Laoise Casserly, Anastasios Damdimopoulos, Anne Panhelainen, L. Lauriina Porokuokka, Jaakko J. Kopra, Giorgio Turconi, Nadine Schweizer, Erika Bereczki, Fredrik Piehl, Göran Engberg, Simon Cervenka, T. Petteri Piepponen, Fu-Ping Zhang, Petra Sipilä, Johan Jakobsson, Carl M. Sellgren, Sophie Erhardt, Jaan-Olle Andressoo
Publikováno v:
Molecular Psychiatry. 27:3247-3261
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that increased expression of endogenous GDNF could induce dopaminergic abnorma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb93a294bf1e16f3933ccb8431b0c73
https://doi.org/10.1038/s41380-022-01554-2
https://doi.org/10.1038/s41380-022-01554-2
Autor:
Soophie Olfat, Kärt Mätlik, Jaakko J. Kopra, Daniel R. Garton, Vilma H. Iivanainen, Dipabarna Bhattacharya, Johan Jakobsson, T. Petteri Piepponen, Jaan-Olle Andressoo
Parkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neuronsin vitroandin vivo, and intracran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe949a3da471338d59b76bbca6ce140f
http://hdl.handle.net/10138/358547
http://hdl.handle.net/10138/358547
Publikováno v:
Journal of neuroscience methods, vol. 354, pp. 109105
PV Cre mice--> combined with AAV-FLEX vectors allowed efficient and specific targeting of PV + interneurons in the striatum. However, diffusion of viral particles to the globus pallidus caused massive transduction of PV + projection neurons and subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493c8c18f83a8742c8046cd59bdb01a5
https://serval.unil.ch/notice/serval:BIB_780C1BCAFFB6
https://serval.unil.ch/notice/serval:BIB_780C1BCAFFB6
Autor:
Jaan-Olle Andressoo, Farhan Alam, Giorgio Turconi, Kärt Mätlik, Tanima SenGupta, Soophie Olfat, Eija Pirinen, Mark S. Schmidt, Vladimir Heiskanen, Sini Pirnes-Karhu, Charles Brenner, Petteri Piepponen, Ana R. Montaño-Rodríguez, Hilde Nilsen, Carina I. Holmberg
Activation of mitochondrial metabolism and proteostasis with the NAD+ precursor nicotinamide riboside (NR) has emerged as a potential therapeutic approach for neurodegenerative disorders including Parkinson’s disease (PD). However, despite recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3c84bbb14c5afe08fa713ba248867d4
https://doi.org/10.1101/2021.03.12.435062
https://doi.org/10.1101/2021.03.12.435062
Autor:
Hao Li, Ana R. Montaño-Rodríguez, Jussi Kupari, Yujuan Gui, Satu Kuure, Jaan-Olle Andressoo, Benson Lu, Soophie Olfat, Sung Ho Huh, Kärt Mätlik, Edward Siefker, Franklin D. Costantini
Due to poor regenerative capacity of adult kidneys, nephron endowment defined by the nephrogenic program during the fetal period dictates renal and related cardiovascular health throughout life. We show that the neurotropic factor GDNF, which is in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f0c93252266cf99936c671ba0646d15
https://doi.org/10.1101/2020.05.28.120865
https://doi.org/10.1101/2020.05.28.120865
Autor:
Mohammad Choopani, Hamid Reza Moozarmpour, Amir Hossein Tajik, Christine Hartoonian, Mehdi Mahdavi, Morteza Kameli, Soophie Olfat, Mohammad Mehdi Adibzadeh, Massoumeh Ebtekar, Roghieh Rahimi, Zuhair Mohammad Hassan, Mohammad Sadegh Beikverdi
Publikováno v:
APMIS. 125:596-603
Cytokines are mediators for polarization of immune response in vaccines. Studies show that co-immunization of DNA vaccines with granulocyte-macrophage colony-stimulating factor (GM-CSF) can increase immune responses. Here, experimental mice were immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe06df8ab975907e9ffd2b04e43cb1ee
https://doi.org/10.1111/apm.12660
https://doi.org/10.1111/apm.12660
Autor:
Jaan-Olle Andressoo, Soophie Olfat, Sara af Bjerkén, Heidi Montonen, Jaakko Kopra, Mart Saarma, Lauriina L. Porokuokka, Kärt Varendi, Anne Panhelainen, T. Petteri Piepponen
Publikováno v:
The Journal of Neuroscience. 37:1581-1590
Midbrain dopamine neuron dysfunction contributes to various psychiatric and neurological diseases, including drug addiction and Parkinson's disease. Because of its well established dopaminotrophic effects, the therapeutic potential of glial cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0963f93ecff3c047bce66a2b63f4b59b
https://doi.org/10.1523/jneurosci.1673-16.2016
https://doi.org/10.1523/jneurosci.1673-16.2016