Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Soong Hoon Kim"'
Autor:
Heather Finlay, Claudia Generaux, Carrie Xu, Chiuwa E. Luk, Ruth R. Wexler, Ji Jiang, James A. Johnson, Michael Galella, Jeffrey S. Bostwick, William A. Schumacher, Tao Wang, Monique Phillips, Soong-Hoon Kim, Yan He, Joelle M. Onorato, Peter S. Gargalovic, Xue-Qing Chen, David A. Gordon
Publikováno v:
Journal of medicinal chemistry. 64(6)
Apelin-13 is an endogenous peptidic agonist of the apelin receptor (APJ) receptor with the potential for improving cardiac function in heart failure patients. However, the low plasma stability of apelin-13 necessitates continuous intravenous infusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa7bda554f3c76e0159bb8b5f189ed9
https://pubmed.ncbi.nlm.nih.gov/33689340
https://pubmed.ncbi.nlm.nih.gov/33689340
Autor:
David S. Taylor, Lei Zhao, Leonard P. Adam, David A. Gordon, Michael Basso, Alice Ye Chen, Eddie C.-K. Liu, Ji Jiang, Christian Caporuscio, Zulan Pi, James A. Johnson, Soong-Hoon Kim, Heather Finlay, John Lloyd, Joelle M. Onorato, Gregory A. Locke, George O. Tora, Ruth R. Wexler, Todd Kirshgessner, Lynn M. Abell, Xiaohong Yin, Hao Lu, Richard Yang, Sarah C. Traeger, Monique Phillips, Kamelia Behnia, Carol S. Ryan
Publikováno v:
Journal of medicinal chemistry. 63(4)
Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic, KO, or loss-of-function variants strongly suggest that inhibition of EL will lead to susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac63d0f0187919bbe4a9cac88560ae41
https://pubmed.ncbi.nlm.nih.gov/31990537
https://pubmed.ncbi.nlm.nih.gov/31990537
Autor:
Lynn M. Abell, Brandon Parkhurst, Lei Zhao, Richard Yang, David A. Gordon, Jennifer X. Qiao, Soong-Hoon Kim, Xue-Qing Chen, Joelle M. Onorato, David S. Taylor, Hao Lu, Michael Basso, Alice Ye Chen, Kamelia Behnia, Heather Finlay, Xiaohong Yin, Leonard P. Adam, Ji Jiang, Gregory A. Locke, George O. Tora, Zulan Pi, Monique Phillips, Christian Caporuscio, Ruth R. Wexler, Eddie C.-K. Liu, James A. Johnson
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(15)
A low level of high density lipoprotein (HDL) is an independent risk factor for cardiovascular disease. HDL reduces inflammation and plays a central role in reverse cholesterol transport, where cholesterol is removed from peripheral tissues and ather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bb80bb08fc94d5bc6f7fade64d10c3
https://pubmed.ncbi.nlm.nih.gov/31353296
https://pubmed.ncbi.nlm.nih.gov/31353296
Autor:
Yufen Zhao, Ashvinikumar V. Gavai, Saulnier Mark G, Demartino Michael P, Claude A. Quesnelle, Brian E. Fink, Libing Chen, Patrice Gill, David B. Frennesson, Soong-Hoon Kim, Phil S. Baran
Publikováno v:
Synlett. 27:2254-2258
An oxidative intermolecular enolate heterocoupling reaction was employed for the synthesis of anti-2,3-disubstituted succinic acid mono- and differentially protected diesters. Tactical approaches to access all the diastereomers are discussed. The met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1ab4c496ef40e73dd1968f7daf87048
https://doi.org/10.1055/s-0035-1561636
https://doi.org/10.1055/s-0035-1561636
Autor:
Eddie C.-K. Liu, James A. Johnson, Lynn M. Abell, Leonard P. Adam, Xue-Qing Chen, Christian Caporuscio, Heather Finlay, Jennifer X. Qiao, Brandon Parkhurst, David S. Taylor, Monique Phillips, Soong-Hoon Kim, Ji Jiang, Joelle M. Onorato, Gregory A. Locke, David A. Gordon, Michael Basso, Alice Ye Chen, George O. Tora, Xiaohong Yin, Ruth R. Wexler, Zulan Pi, Richard Yang, Kamelia Behnia, Lei Zhao, Hao Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2525
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9051398c276805e08d7346ea27e17323
https://doi.org/10.1016/j.bmcl.2019.07.032
https://doi.org/10.1016/j.bmcl.2019.07.032
Synthesis, Chromatographic Purification, and Isolation of Epothilone–Folic Acid Conjugate BMS-753493
Autor:
Riccardo E. Frigerio, Soong-Hoon Kim, Xujin Lu, Wei Wang, Nuria de Mas, Bing-Shiou Yang, Kevin P. Girard, Olav Lyngberg, Zhenrong Guo, Victor W. Rosso, Zerene A. Manaloto, Gokhale Madhushree Yeshwant, Mark S. Bolgar, Luca Parlanti, Ajit B. Thakur, Germano D'arasmo, Konstantinos Dambalas, Guido Ströhlein
Publikováno v:
Organic Process Research & Development. 15:797-809
We describe the synthesis, chromatographic purification, and isolation of the epothilone–folic acid conjugate BMS-753493, an investigational new drug candidate for the treatment of cancer. The main challenges for process development were the instab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d3c637efff9ba0e17b0eb1f0c1485d
https://doi.org/10.1021/op200023g
https://doi.org/10.1021/op200023g
Autor:
Johnni Gullo-Brown, Michael A. Poss, Wayne Vaccaro, Tram N. Huynh, Stephanie Barbosa, Carolyn S. Ricca, Mark E. Salvati, Veeraswamy Manne, Zhong Chen, Kenneth J. Leavitt, Soong-Hoon Kim, David R. Tortolani, Donna D. Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:628-632
The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b1ce0dc69568349a8c7b57436978aa
https://doi.org/10.1016/j.bmcl.2005.10.052
https://doi.org/10.1016/j.bmcl.2005.10.052
Autor:
Bruce M. Rankin, William J. Pitts, William J. Metzler, Kenneth J. Leavitt, Andrew T. Pudzianowski, Wayne Vaccaro, Richard Liu, Patricia A. McDonnell, Joseph Barbosa, Soong-Hoon Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1101-1106
Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb80a697ae0815fd51299759604589da
https://doi.org/10.1016/j.bmcl.2004.12.016
https://doi.org/10.1016/j.bmcl.2004.12.016
Autor:
Craig R. Fairchild, John D. Dimarco, Robert M. Borzilleri, Soong-Hoon Kim, Jack Z. Gougoutas, Francis Y. Lee, James A. Johnson, Gregory D. Vite, Robert J. Schmidt, and Byron H. Long, Xiaoping Zheng
Publikováno v:
Journal of the American Chemical Society. 122:8890-8897
Several lactam analogues of the epothilones were prepared using a concise semisynthetic approach starting with the unprotected natural products. Highlighted in this strategy is a novel regio- and stereoselective Pd(0)-catalyzed azidation reaction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66ac1045d8f200bd917adb8ac7ccb4c
https://doi.org/10.1021/ja001899n
https://doi.org/10.1021/ja001899n
Autor:
Joseph Fargnoli, Jonathan Lippy, Ashok V. Purandare, John T. Hunt, Libing Chen, Brian E. Fink, John S. Tokarski, Andrew Nation, Soong-Hoon Kim, Yufen Zhao, William R. Foster, Ashvinikumar V. Gavai, Tai W. Wong, Gregory D. Vite, Urvashi V. Roongta, Aberra Fura, Brent A. Rupnow, Jonathan G. Pabalan, Benjamin J. Henley, Christine M. Tarby, Mary T. Obermeier, Chiang Yu, Liqi He, Paul A. Elzinga
Publikováno v:
Cancer Research. 75:5417-5417
CK2 is a highly conserved, and constitutively active family of serine/threonine kinases abnormally elevated in a wide variety of cancers and linked to poor prognosis and disease progression. The enzymes form as hetero-tetrameric complexes comprised o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4be7e90e625f1f1f20fd7eb879bc6e
https://doi.org/10.1158/1538-7445.am2015-5417
https://doi.org/10.1158/1538-7445.am2015-5417