Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Soon Y. Choong"'
Autor:
Soon Y. Choong, Hsiang-Ning Chao, Christopher S. Walker, Kerry M. Loomes, Hao-Han Chang, Anthony R. J. Phillips
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F755-F763
Renal depletion of myo-inositol (MI) is associated with the pathogenesis of diabetic nephropathy in animal models, but the underlying mechanisms involved are unclear. We hypothesized that MI depletion was due to changes in inositol metabolism and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13417539e32ad5bf19ee64ce786b5606
https://doi.org/10.1152/ajprenal.00164.2015
https://doi.org/10.1152/ajprenal.00164.2015
Autor:
Garth J. S. Cooper, Gretchen L. Skea, Silvana de Freitas Costa, Soon Y. Choong, Mia Jüllig, Martin Middleditch, Anthony Philips, Anthony J. R. Hickey, Chau C. Chai
Publikováno v:
PROTEOMICS. 8:2556-2572
Hypertension now affects about 600 million people worldwide and is a leading cause of death in the Western world. The spontaneously hypertensive rat (SHR), provides a useful model to investigate hypertensive heart failure (HF). The SHR model replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9599d94c2e049b56224b11a31aeac6
https://doi.org/10.1002/pmic.200700977
https://doi.org/10.1002/pmic.200700977
Autor:
Soon Y. Choong, Garth J. S. Cooper, Sarah Song, Michael A. Black, Anthony R. J. Phillips, Sarah Glyn-Jones
Publikováno v:
Physiological Genomics. 28:284-293
Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Diabetic cardiomyopathy (DCM) is increasingly recognized as a major contributor to diastolic dysfunction and he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4b68329176e4e14799463de93bc41f
https://doi.org/10.1152/physiolgenomics.00204.2006
https://doi.org/10.1152/physiolgenomics.00204.2006
Autor:
Gregory D. Gamble, Yih-Kai Chan, Sarah Glyn-Jones, Anthony R. J. Phillips, Deming Gong, Garth J. S. Cooper, Jun Lu, Soon Y. Choong, Shaoping Zhang, Xiuyin Chen
Publikováno v:
Molecular Pharmacology. 70:2045-2051
Most patients with diabetes die from cardiac or arterial disease, for which there are limited therapeutic options. Free Cu(2+) ions are strongly pro-oxidant, and chelatable-Cu(II) is increased in the diabetic heart. We reported previously that treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88706a45356c62bf7da033be532a6f8b
https://doi.org/10.1124/mol.106.028605
https://doi.org/10.1124/mol.106.028605
Autor:
Deming Gong, Soon Y. Choong, S. Fitzpatrick, Jun Lu, Sarah Glyn-Jones, Victor Obolonkin, Shaoping Zhang, Yih-Kai Chan, Xiuyin Chen, Tomoyuki Nakamura, Katya Ruggiero, Hong Xu, Sally D. Poppitt, Garth J. S. Cooper, Anthony R. J. Phillips
Publikováno v:
Diabetologia. 53(6)
Treatment with the Cu(II)-selective chelator triethylenetetramine (TETA) improves cardiovascular disease in human patients, and cardiac and vascular/renal disease in rats used as a model of diabetes. Here we tested two hypotheses: first, that TETA el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5912d7b6e545eaac8a8e853437155e00
https://pubmed.ncbi.nlm.nih.gov/20221822
https://pubmed.ncbi.nlm.nih.gov/20221822
Autor:
Anthony J. R. Hickey, Silvana de Freitas Costa, Soon Y. Choong, Gretchen L. Skea, Chau C. Chai, Garth J. S. Cooper, Anthony R. J. Phillips
Publikováno v:
American journal of physiology. Cell physiology. 297(3)
Although most attention has been focused on mitochondrial ATP production and transfer in failing hearts, less has been focused on the nonfailing hypertensive heart. Here, energetic complications are less obvious, yet they may provide insight into dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8752329908353d467299269f8e1da8e6
https://pubmed.ncbi.nlm.nih.gov/19553568
https://pubmed.ncbi.nlm.nih.gov/19553568
Autor:
Grant R. Allen, Bridget L. Leonard, Garth J. S. Cooper, Ajith Dissanayake, F. E. Leahy, John Richard Baker, Thomas K. Borg, Etuate L. Saafi, Geraldine F. Keogh, Adèle J. Pope, Robert N. Doughty, Dianne H. Brunton, Peter D. W. Boyd, Gregory D. Gamble, Yih-Kai Chan, Sally D. Poppitt, Brett R. Cowan, Anthony R. J. Phillips, Soon Y. Choong, Alistair A. Young, Christopher J. Occleshaw, David J. Crossman
Publikováno v:
Diabetes. 53(9)
Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Although altered systemic regulation of transition metals in diabetes has been the subject of previous investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440436332f6ea790ecd279577fd2407d
https://pubmed.ncbi.nlm.nih.gov/15331567
https://pubmed.ncbi.nlm.nih.gov/15331567
Autor:
Garth J. S. Cooper, Anthony R. J. Phillips, Alistair A. Young, Brett R. Cowan, Beau Pontre, Hong Xu, Gregory D. Gamble, Stephen Pickup, Soon Y. Choong, Mingming Li, Jun Lu
Publikováno v:
Cardiovascular Diabetology
Background Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in diabetes, wherein it also ame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67153e65ebd77f426075618951c00cfb