Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Soon Seng Ng"'
Autor:
Chao Zheng Li, Hiromi Ogawa, Soon Seng Ng, Xindi Chen, Eriko Kishimoto, Kokoro Sakabe, Aiko Fukami, Yueh-Chiang Hu, Christopher N. Mayhew, Jennifer Hellmann, Alexander Miethke, Nahrin L. Tasnova, Samuel J.I. Blackford, Zu Ming Tang, Adam M. Syanda, Liang Ma, Fang Xiao, Melissa Sambrotta, Oliver Tavabie, Filipa Soares, Oliver Baker, Davide Danovi, Hisamitsu Hayashi, Richard J. Thompson, S. Tamir Rashid, Akihiro Asai
Publikováno v:
JHEP Reports, Vol 4, Iss 4, Pp 100446- (2022)
Background & Aims: The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are no targeted medications for the liver pa
Externí odkaz:
https://doaj.org/article/a3897953261242379e6856ff67f6e514
Autor:
Adam M. Syanda, Vera I. Kringstad, Samuel J. I. Blackford, Joachim S. Kjesbu, Soon Seng Ng, Liang Ma, Fang Xiao, Abba E. Coron, Anne Mari A. Rokstad, Sunil Modi, S. Tamir Rashid, Berit Løkensgard Strand
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Intra-peritoneal placement of alginate encapsulated human induced pluripotent stem cell-derived hepatocytes (hPSC-Heps) represents a potential new bridging therapy for acute liver failure. One of the rate-limiting steps that needs to be overcome to m
Externí odkaz:
https://doaj.org/article/f457da41d2f843768b7ad1d228d8561c
Autor:
Joe M. Segal, Deniz Kent, Daniel J. Wesche, Soon Seng Ng, Maria Serra, Bénédicte Oulès, Gozde Kar, Guy Emerton, Samuel J. I. Blackford, Spyros Darmanis, Rosa Miquel, Tu Vinh Luong, Ryo Yamamoto, Andrew Bonham, Wayel Jassem, Nigel Heaton, Alessandra Vigilante, Aileen King, Rocio Sancho, Sarah Teichmann, Stephen R. Quake, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of c
Externí odkaz:
https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d3
Autor:
John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 693-702 (2018)
Summary: Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap. Using image-ba
Externí odkaz:
https://doaj.org/article/7c1f980085ad4d33ad10a8f4d8dd7616
Autor:
Samuel J.I. Blackford, Tracy T.L. Yu, Michael D.A. Norman, Adam M. Syanda, Michail Manolakakis, Dariusz Lachowski, Ziqian Yan, Yunzhe Guo, Elena Garitta, Federica Riccio, Geraldine M. Jowett, Soon Seng Ng, Santiago Vernia, Armando E. del Río Hernández, Eileen Gentleman, S. Tamir Rashid
Publikováno v:
Gentleman, E, Rashid, T, Blackford, S, Jowett, G, Yan, Z, Yu, T, Norman, M, Guo, Y, Syanda, A, Riccio, F, Ng, S S, Manolakakis, M, Lachowski, D, Garrita, E, Vernia, S & de Rio Hernandez, A 2023, ' RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling ', Biomaterials, vol. 293, 121982 . https://doi.org/10.1016/j.biomaterials.2022.121982
Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised that replicating healthy liver niche biochemical and biophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d9ea300a57246addd8c417a8dad89a
http://hdl.handle.net/10044/1/102659
http://hdl.handle.net/10044/1/102659
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:643-651
The 3D cell culture model is an indispensable tool in the study of liver biology in the field of health and disease and the development of clinically relevant products for liver therapies. The 3D culture model captures critical factors of the microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e140aa3cc4ed7c793911c65a2ca933
https://doi.org/10.1093/abbs/gmab046
https://doi.org/10.1093/abbs/gmab046
Autor:
Pearlyn Jia Ying Toh, Yue Zhang, Cornelia Monzel, S. Tamir Rashid, Vidhyalakshmi Acharya, Hanry Yu, Virgile Viasnoff, Jasmine Fei Li Chin, Noémi van Hul, Inn Chuan Ng, Richard De Mets, Soon Seng Ng
Publikováno v:
Nature Materials. 19:1026-1035
The symmetry breaking of protein distribution and cytoskeleton organization is an essential aspect for the development of apicobasal polarity. In embryonic cells this process is largely cell autonomous, while differentiated epithelial cells collectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::961ba6831073c3cff3a9943f26987179
https://doi.org/10.1038/s41563-020-0662-3
https://doi.org/10.1038/s41563-020-0662-3
Autor:
Deniz Kent, Soon Seng Ng, Payam Khoshkenar, Adam Syanda, Chao Zheng Li, Marina Zieger, Stephanie Hatch, Joe Segal, Samuel Blackford, Kaixing Le, Vivek Chowdary, Taylor Ismaili, Davide Danovi, Patrick Lewis, Sunil Sahdeo, Daniel Ebner, Christian Mueller, S. Tamir Rashid
Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by inheritance of the SERPINA1-Z genetic variant (PiZ) leading to protein misfolding and liver toxicity. There remain no approved medicines for this disease. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8daaf1f53f7f2962db34f88649f13a
https://doi.org/10.21203/rs.3.rs-1283764/v1
https://doi.org/10.21203/rs.3.rs-1283764/v1
Autor:
Pearlyn Jia Ying Toh, Cornelia Monzel, R. De Mets, Virgile Viasnoff, N. Van Hul, T. Rashid, Soon Seng Ng, Yi Zhang
Symmetry breaking of protein distribution and cytoskeleton organization is an essential aspect for development of apico-basal polarity. In embryonic cells this process is largely cell autonomous, while differentiated epithelial cells collectively pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc390d79f566ea498cf77bdd62ff8de
https://doi.org/10.1101/636654
https://doi.org/10.1101/636654
Autor:
Yue, Zhang, Richard, De Mets, Cornelia, Monzel, Vidhyalakshmi, Acharya, Pearlyn, Toh, Jasmine Fei Li, Chin, Noémi, Van Hul, Inn Chuan, Ng, Hanry, Yu, Soon Seng, Ng, S, Tamir Rashid, Virgile, Viasnoff
Publikováno v:
Nature materials. 19(9)
The symmetry breaking of protein distribution and cytoskeleton organization is an essential aspect for the development of apicobasal polarity. In embryonic cells this process is largely cell autonomous, while differentiated epithelial cells collectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::491775f12dfe1d71496e42983c0838b7
https://pubmed.ncbi.nlm.nih.gov/32820290
https://pubmed.ncbi.nlm.nih.gov/32820290