Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Sook-Kyung Lee"'
Autor:
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
Publikováno v:
eLife, Vol 12 (2023)
Darunavir (DRV) is exceptional among potent HIV-1 protease inhibitors (PIs) in high drug concentrations that are achieved in vivo. Little is known about the de novo resistance pathway for DRV. We selected for resistance to high drug concentrations ag
Externí odkaz:
https://doaj.org/article/63dc44fcc5244ba9ab0bca60d287bf74
Publikováno v:
Gut and Liver, Vol 13, Iss 3, Pp 342-348 (2019)
Background/Aims Sorafenib remains the only approved molecular targeted agent for hepatocellular carcinoma (HCC); however, reliable biomarkers that predict its efficacy are still lacking. The aim of this study was to explore whether cancer stem cell (
Externí odkaz:
https://doaj.org/article/ba3075a420594b60b9025e35cd78a33c
Autor:
Gordon J. Lockbaum, Linah N. Rusere, Mina Henes, Klajdi Kosovrasti, Desaboini Nageswara Rao, Ean Spielvogel, Sook-Kyung Lee, Ellen A. Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali
Publikováno v:
European Journal of Medicinal Chemistry. 257:115501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc22305456191ac01cd91889fe25e7b1
https://doi.org/10.1016/j.ejmech.2023.115501
https://doi.org/10.1016/j.ejmech.2023.115501
Autor:
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2f9584e5a43e5c4421a1c91f47d580
https://doi.org/10.7554/elife.80328.sa2
https://doi.org/10.7554/elife.80328.sa2
Autor:
Spielvoge, Ean, Sook-Kyung Lee, Zhou, Shuntai, Lockbaum, Gordon J., Henes, Mina, Sondgeroth, Amy, Kosovrasti, Klajdi, Nalivaika, Ellen A., Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A., Swanstrom, Ronald
Publikováno v:
eLife; 3/31/2023, p1-26, 26p
Autor:
Hyun-Sung Kim, Byoung Wan Kim, Younguk Won, Young Jae Oh, Jihun Lee, Sa Young Hong, Kyunghun Kang, Sook-Kyung Lee, Jung-Jae Park
Publikováno v:
OCEANS 2021: San Diego – Porto.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a91d34229c435f8a0edd3ddbd2db6c72
https://doi.org/10.23919/oceans44145.2021.9706075
https://doi.org/10.23919/oceans44145.2021.9706075
Autor:
Gordon J. Lockbaum, Celia A. Schiffer, Ellen A. Nalivaika, Nese Kurt Yilmaz, Linah N. Rusere, Mina Henes, Sook-Kyung Lee, Klajdi Kosovrasti, Ronald Swanstrom, Akbar Ali, Ean Spielvogel
Publikováno v:
J Med Chem
A structure-guided design strategy was used to improve the resistance profile of HIV-1 protease inhibitors by optimizing hydrogen bonding and van der Waals interactions with the protease while staying within the substrate envelope. Stereoisomers of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd17d85004f72f6d3054a61ca9e475
https://doi.org/10.1021/acs.jmedchem.9b00838
https://doi.org/10.1021/acs.jmedchem.9b00838
Publikováno v:
Gut and Liver
Background/Aims Sorafenib remains the only approved molecular targeted agent for hepatocellular carcinoma (HCC); however, reliable biomarkers that predict its efficacy are still lacking. The aim of this study was to explore whether cancer stem cell (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ef6d15a358217b74ce4512ad65d863
http://europepmc.org/articles/PMC6529171
http://europepmc.org/articles/PMC6529171
Autor:
Charles W. Carter, Ean Spielvogel, Marc Potempa, Celia A. Schiffer, Ronald Swanstrom, Amy Rogers, Nese Kurt Yilmaz, Ellen A. Nalivaika, Sook Kyung Lee
Publikováno v:
Journal of Molecular Biology. 430:5182-5195
Retroviral proteases (PR) have a unique specificity that allows cleavage of sites with or without a P1’ proline. A P1’ proline is required at the MA/CA cleavage site due to its role in a post-cleavage conformational change in the capsid protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29d70bca9a74f6bbc0c3f0f02e72899
https://doi.org/10.1016/j.jmb.2018.10.022
https://doi.org/10.1016/j.jmb.2018.10.022
Autor:
Sook-Kyung Lee, Mina Henes, Ronald Swanstrom, Celia A. Schiffer, Linah N. Rusere, Klajdi Kosovrasti, Ean Spielvogel, Akbar Ali, Gordon J. Lockbaum, Desaboini Nageswara Rao, Nese Kurt Yilmaz, Ellen A. Nalivaika
Publikováno v:
J Med Chem
The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C2-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d68a1620aaedab54d48716ccf0a5ee
https://pubmed.ncbi.nlm.nih.gov/32672965
https://pubmed.ncbi.nlm.nih.gov/32672965