Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sook-Hyun Chung"'
Autor:
Sook Hyun Chung, Tzu-Ni Sin, Brian Dang, Taylor Ngo, Therlinder Lo, Daniella Lent-Schochet, Ratheesh K. Meleppat, Robert J. Zawadzki, Glenn Yiu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 613-622 (2022)
Clustered regularly interspaced short palindromic repeats (CRISPR)-based genomic disruption of vascular endothelial growth factor A (Vegfa) with a single gRNA suppresses choroidal neovascularization (CNV) in preclinical studies, offering the prospect
Externí odkaz:
https://doaj.org/article/bfb44be0cc0747e8bd3c8d258b7ce193
Autor:
Sook Hyun Chung, Iris Natalie Mollhoff, Uyen Nguyen, Amy Nguyen, Natalie Stucka, Eric Tieu, Suman Manna, Ratheesh Kumar Meleppat, Pengfei Zhang, Emerald Lovece Nguyen, Jared Fong, Robert Zawadzki, Glenn Yiu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 409-417 (2020)
Frequent injections of anti-vascular endothelial growth factor (anti-VEGF) agents are a clinical burden for patients with neovascular age-related macular degeneration (AMD). Genomic disruption of VEGF-A using adeno-associated viral (AAV) delivery of
Externí odkaz:
https://doaj.org/article/fcf7aef49a2349ed9ced422596669c24
Autor:
Glenn Yiu, Sook Hyun Chung, Iris N. Mollhoff, Uyen Tu Nguyen, Sara M. Thomasy, Jesse Yoo, Donna Taraborelli, Glenn Noronha
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 179-191 (2020)
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery an
Externí odkaz:
https://doaj.org/article/43af1bbe86bd407695b7807901aa2def
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2020)
Among genome engineering tools, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based approaches have been widely adopted for translational studies due to their robustness, precision, and ease of use. When delivered to diseased tis
Externí odkaz:
https://doaj.org/article/0199719195ee4b56970bc6f4a55dba00
Autor:
Sook Hyun Chung, Weiyong Shen, Kathryn C. Davidson, Alice Pébay, Raymond C. B. Wong, Belinda Yau, Mark Gillies
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Dysfunction of retinal glial cells, particularly Müller cells, has been implicated in several retinal diseases. Despite their important contribution to retinal homeostasis, a specific way to differentiate retinal glial cells from human pluripotent s
Externí odkaz:
https://doaj.org/article/0d0dd87d52a74f51afd2275bf393ab8b
Autor:
Tzu-Ni Sin, Sangbae Kim, Yumei Li, Jun Wang, Rui Chen, Sook Hyun Chung, Soohyun Kim, M. Isabel Casanova, Sangwan Park, Zeljka Smit-McBride, Ning Sun, Ori Pomerantz, Jeffrey A. Roberts, Bin Guan, Robert B. Hufnagel, Ala Moshiri, Sara M. Thomasy, Paul A. Sieving, Glenn Yiu
Publikováno v:
Investigative ophthalmology & visual science, vol 64, iss 1
PurposeFoveoschisis involves the pathologic splitting of retinal layers at the fovea, which may occur congenitally in X-linked retinoschisis (XLRS) or as an acquired complication of myopia. XLRS is attributed to functional loss of the retinal adhesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd4ac56d94203667e046faa22a1dd4
https://escholarship.org/uc/item/3xz196xw
https://escholarship.org/uc/item/3xz196xw
Autor:
Eric Tieu, Sook Hyun Chung, Jared H. Fong, Uyen Thao Nguyen, Glenn Yiu, Emerald Lovece Nguyen, Amy Nguyen, Ratheesh Kumar Meleppat, Natalie Stucka, Robert J. Zawadzki, Pengfei Zhang, Suman K. Manna, Iris Natalie Mollhoff
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 409-417 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Frequent injections of anti-vascular endothelial growth factor (anti-VEGF) agents are a clinical burden for patients with neovascular age-related macular degeneration (AMD). Genomic disruption of VEGF-A using adeno-associated viral (AAV) delivery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe5396b52a2ba2618d3203a046ac0e4
https://doi.org/10.1016/j.omtm.2020.01.006
https://doi.org/10.1016/j.omtm.2020.01.006
Autor:
Sara M Thomasy, Sook Hyun Chung, Glenn Yiu, Jesse Yoo, Uyen Tu Nguyen, Glenn Noronha, Donna Taraborelli, Iris Natalie Mollhoff
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 179-191 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5726d4cc03618ee98211c7672284c11d
https://doi.org/10.1016/j.omtm.2020.01.002
https://doi.org/10.1016/j.omtm.2020.01.002
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118949 (2015)
Dysfunction of Müller cells has been implicated in the pathogenesis of several retinal diseases. In order to understand the potential contribution of Müller cells to retinal disease better, we have developed a transgenic model in which foci of Mül
Externí odkaz:
https://doaj.org/article/6cc4f3c0115f454a9601d7dcb067ef1d
Autor:
Alaknanda Mishra, Sook Hyun Chung, Tzu Ni Sin, Glenn Yiu, Paul A. Sieving, Thomas Ciulla, Iris Natalie Mollhoff, Taylor Ngo, Sara M Thomasy
Publikováno v:
Human gene therapy, vol 32, iss 13-14
Human Gene Therapy
Human Gene Therapy
The suprachoroid is a potential space located between the sclera and choroid of the eye, which provides a novel route for ocular drug or viral vector delivery. Suprachoroidal injection of adeno-associated virus (AAV)8 using transscleral microneedles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6429fbbe1d22008cee3abfe57f9ec0c
https://escholarship.org/uc/item/3k82s8ng
https://escholarship.org/uc/item/3k82s8ng