Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sook Yoong, Chia"'
Autor:
Haitao Tu, Zhi Wei Zhang, Lifeng Qiu, Yuning Lin, Mei Jiang, Sook-Yoong Chia, Yanfei Wei, Adeline S. L. Ng, Richard Reynolds, Eng-King Tan, Li Zeng
Publikováno v:
BMC Neuroscience, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are common age-related neurodegenerative diseases comprising Lewy body spectrum disorders associated with cortical and subcortical Lewy body pathology. Over 30% of PD
Externí odkaz:
https://doaj.org/article/e55c1f3e95b149b28234f2e9f09bd2e8
Autor:
Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zeng
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in the VPS35 gene have been identifi
Externí odkaz:
https://doaj.org/article/85c535b2d2c24c6982aab9b8d5a79aef
Autor:
Diana Teh Chee Siang, Yen Ching Lim, Aung Maung Maung Kyaw, Khaing Nwe Win, Sook Yoong Chia, Ufuk Degirmenci, Xiang Hu, Bryan C. Tan, Arcinas Camille Esther Walet, Lei Sun, Dan Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human antigen R (HuR) is an RNA binding protein that promotes mRNA stability. Here the authors show that HuR represses adipogenesis in white and brown adipose tissue by stabilizing Insig1 and other targets.
Externí odkaz:
https://doaj.org/article/d5a3ed7333c84e9d83c9d20cc549253a
Autor:
Chunming Ding, Yen Ching Lim, Sook Yoong Chia, Arcinas Camille Esther Walet, Shaohai Xu, Kinyui Alice Lo, Yanling Zhao, Dewen Zhu, Zhihui Shan, Qingfeng Chen, Melvin Khee-Shing Leow, Dan Xu, Lei Sun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Long non-coding RNAs are known to regulate mouse white adipose tissue development and brown adipose tissue program expression. Here, the authors construct a roadmap for human long non-coding RNAs expressed in fetal brown adipose tissue, adult omental
Externí odkaz:
https://doaj.org/article/f9650c4841264881a512ef772db8f1a0
Autor:
Sook Yoong Chia, Ashwati Vipin, Kok Pin Ng, Haitao Tu, Ananth Bommakanti, Brian Zhiyang Wang, Yi Jayne Tan, Fatin Zahra Zailan, Adeline Su Lyn Ng, Shuo-Chien Ling, Katsutomo Okamura, Eng-King Tan, Nagaendran Kandiah, Li Zeng
Publikováno v:
Journal of Alzheimer's Disease. 88:1567-1584
Background: There is an urgent need for noninvasive, cost-effective biomarkers for Alzheimer’s disease (AD), such as blood-based biomarkers. They will not only support the clinical diagnosis of dementia but also allow for timely pharmacological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a535883a7625564b4499f66526522c7b
https://doi.org/10.3233/jad-220116
https://doi.org/10.3233/jad-220116
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 1033-1041 (2016)
Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Methods: We performed reduced representation bisulfite sequencing (RRBS) and RNA-seq to depict a genome-wide integrative view of the DNA methylome and tra
Externí odkaz:
https://doaj.org/article/c376565141bc458b9816b22242069847
Autor:
Zhiqiang Bai, Xiao-Ran Chai, Myeong Jin Yoon, Hye-Jin Kim, Kinyui Alice Lo, Zhi-Chun Zhang, Dan Xu, Diana Teh Chee Siang, Arcinas Camille Esther Walet, Shao-Hai Xu, Sook-Yoong Chia, Peng Chen, Hongyuan Yang, Sujoy Ghosh, Lei Sun
Publikováno v:
PLoS Biology, Vol 15, Iss 8, p e2002176 (2017)
Enhancing brown fat activity and promoting white fat browning are attractive therapeutic strategies for treating obesity and associated metabolic disorders. To provide a comprehensive picture of the gene regulatory network in these processes, we cond
Externí odkaz:
https://doaj.org/article/7cc8185910004ae1a1ec7b9bad56ee1e
Autor:
Zhi-Wei, Zhang, Haitao, Tu, Mei, Jiang, Sarivin, Vanan, Sook Yoong, Chia, Se-Eun, Jang, Wuan-Ting, Saw, Zhi-Wei, Ong, Dong-Rui, Ma, Zhi-Dong, Zhou, Jie, Xu, Kai-Hua, Guo, Wei-Ping, Yu, Shuo-Chien, Ling, Richard A, Margolin, Daniel G, Chain, Li, Zeng, Eng-King, Tan
Publikováno v:
Science signaling. 15(748)
Gain-of-function mutations in the leucine-rich repeat kinase 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a63e5fba0092140ba19a72457efecdd2
https://pubmed.ncbi.nlm.nih.gov/35998231
https://pubmed.ncbi.nlm.nih.gov/35998231
Autor:
Bryan C. Tan, Sook Yoong Chia, Yen Ching Lim, Arcinas Camille Esther Walet, Ufuk Degirmenci, Diana Teh Chee Siang, Lei Sun, Khaing Nwe Win, Xiang Hu, Dan Xu, Aung Maung Maung Kyaw
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in metabolism remains unclear. This study identifies HuR as a major repressor during adipogenesis. Knockdown and overexpression of HuR in primary adipocyte culture en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7d7c6252c793cbdddb8baf5976959e
http://link.springer.com/article/10.1038/s41467-019-14001-8
http://link.springer.com/article/10.1038/s41467-019-14001-8
Autor:
Sivaramapanicker Sreejith, Sook Yoong Chia, Ramanathan Vaidyanathan, Nagaendran Kandiah, Yi Jayne Tan, Adeline S.L. Ng, Li Zeng, Benjamin Y.X. Wong
Publikováno v:
Journal of Alzheimer's Disease Reports
Background: micro-RNAs (miRNAs) are stable, small, non-coding RNAs enriched in exosomes. Their variation in levels according to different disease etiologies have made them a promising diagnostic biomarker for neurodegenerative diseases such as Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e89af3dd23b4c6a5273d7caddf049e
https://pubmed.ncbi.nlm.nih.gov/34870106
https://pubmed.ncbi.nlm.nih.gov/34870106