Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sook Wern Chua"'
Autor:
Mian Bi, Amadeus Gladbach, Janet van Eersel, Arne Ittner, Magdalena Przybyla, Annika van Hummel, Sook Wern Chua, Julia van der Hoven, Wei S. Lee, Julius Müller, Jasneet Parmar, Georg von Jonquieres, Holly Stefen, Ernesto Guccione, Thomas Fath, Gary D. Housley, Matthias Klugmann, Yazi D. Ke, Lars M. Ittner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Externí odkaz:
https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e1
Autor:
Astrid F. Feiten, Nikolas K. Haass, Esmeralda Paric, Yazi D. Ke, Yuanyuan Deng, Annika van Hummel, Gabriella Chan, Sook Wern Chua, Lars M. Ittner, Celine Heu, Julia van der Hoven, Thomas Fath, Stefania Ippati
Publikováno v:
Proc Natl Acad Sci U S A
Neurons are postmitotic cells. Reactivation of the cell cycle by neurons has been reported in Alzheimer’s disease (AD) brains and models. This gave rise to the hypothesis that reentering the cell cycle renders neurons vulnerable and thus contribute
Autor:
Ittner, Arne1 a.ittner@unsw.edu.au, Sook Wern Chua1, Bertz, Josefine1, Volkerling, Alexander1, van der Hoven, Julia1, Gladbach, Amadeus1, Przybyla, Magdalena1, Mian Biz1, van Hummel, Annika1,2, Stevens, Claire H.1, Ippati, Stefania1, Suh, Lisa S.1,3, Macmillan, Alexander4, Sutherland, Greg3, Kril, Jillian J.3, Silva, Ana P. G.5, Mackay, Joel5, Poljak, Anne6, Delerue, Fabien1,7, Ke, Yazi D.2
Publikováno v:
Science. 11/18/2016, Vol. 354 Issue 6314, p904-908. 5p. 4 Graphs.
Autor:
Julius Muller, Magdalena Przybyla, Holly Stefen, Amadeus Gladbach, Ernesto Guccione, Gary D. Housley, Thomas Fath, Wei S. Lee, Lars M. Ittner, Annika van Hummel, Jasneet Parmar, Julia van der Hoven, Mian Bi, Arne Ittner, Matthias Klugmann, Yazi D. Ke, Janet van Eersel, Sook Wern Chua, Georg von Jonquieres
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau−/−) mice are profoundly protected from excitotoxic brain damage and neurological deficit
Autor:
Lars M. Ittner, Josefine Bertz, Pall Thordarson, Yazi D. Ke, Sook Wern Chua, Yijun Lin, Carol G. Au, Thomas Fath, Magdalena Przybyla, Holly Stefen, Adam D. Martin
Publikováno v:
ACS applied materialsinterfaces. 10(30)
The culturing of primary neurons represents a central pillar of neuroscience research. Primary neurons are derived directly from brain tissue and recapitulate key aspects of neuronal development in an in vitro setting. Unlike neural stem cells, prima
Autor:
Ippati, Stefania, Yuanyuan Deng, van der Hoven, Julia, Heu, Celine, van Hummel, Annika, Sook Wern Chua, Paric, Esmeralda, Chan, Gabriella, Feiten, Astrid, Fath, Thomas, Ke, Yazi D., Haass, Nikolas K., Ittner, Lars M.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/23/2021, Vol. 118 Issue 12, p1-9, 9p
Autor:
Sook Wern Chua, Amadeus Gladbach, Renee Whan, Alexander Macmillan, Michael Kassiou, Mercedes Cueto, Lev Lewis, Inmaculada Vaca, Janet van Eersel, Lars M. Ittner, Alberto Cornejo, Claire H. Stevens
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In Alzheimer’s disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (NFTs). A critical step in the formation of NFTs is the conversion of soluble tau into insoluble filaments. Accordingly, a current therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6845d59b8d77eb582c41dc82316c5c
http://hdl.handle.net/10261/185311
http://hdl.handle.net/10261/185311
Publikováno v:
Expert Review of Neurotherapeutics. 14:439-448
The translocator protein (TSPO) recently emerged as a potential drug target in Alzheimer's disease (AD). This has been fuelled mainly by positron emission topography studies that show the upregulation of TSPO in AD, especially in relation to microgli
Autor:
Sook Wern Chua, Lars M. Ittner, Michael Kassiou, Tristan A. Reekie, Renee Sokias, Erick C.N. Wong, Eryn L. Werry, Lenka Munoz
The 18 kDa translocator protein (TSPO) is a target for development of diagnostic imaging agents for glioblastoma and neuroinflammation. Clinical translation of TSPO imaging agents has been hindered by the presence of a polymorphism, rs6971, which cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d5ef87e27098fbb99c9a2e5be3db62
https://zenodo.org/record/291817
https://zenodo.org/record/291817
Autor:
Anne Poljak, Sook Wern Chua, Lisa S. Suh, Yazi D. Ke, Jillian J. Kril, Mian Bi, Joel P. Mackay, Alexander Volkerling, Alexander Macmillan, Lars M. Ittner, Ana P. G. Silva, Fabien Delerue, Greg T. Sutherland, Magdalena Przybyla, Arne Ittner, Annika van Hummel, Amadeus Gladbach, Stefania Ippati, Julia van der Hoven, Josefine Bertz, Claire H. Stevens
Publikováno v:
Science (New York, N.Y.). 354(6314)
Tau phosphorylation—not all bad Alzheimer's disease presents with amyloid-β (Aβ) plaques and tau tangles. The prevailing idea in the field is that Aβ induces phosphorylation of tau, which in turn mediates neuronal dysfunction. Working in Alzheim