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Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells

Autor: Byungsuk Kwon, Juyang Kim, Soojin La, Byoung S. Kwon, Byoung-Sam Kim, Hong R. Cho, Woon S. Choi, Jae-Hee Suh

Publikováno v: Blood. 105:2206-2213

4-1BB, a member of the tumor necrosis factor (TNF) receptor superfamily, is a costimulator for activated T cells. Previous studies have established that treatment with agonistic anti–4-BB monoclonal antibody (3H3) is effective in reversing the prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c56d97fcaf160da2a2a7d9551d924d2
https://doi.org/10.1182/blood-2004-06-2080

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Newly dentified members of the TNF recept or superfamily (mTNFRH1 and mTNFRH2) inhibit T-cell proliferation

Autor: Juyang Kim, Byung-Sam Kim, Byungsuk Kwon, Soojin La, Byoung S. Kwon

Publikováno v: Experimental & Molecular Medicine. 35:154-159

By searching an EST database, we identified two TNF receptor superfamily members (named mTNFRH1 and mTNFRH2). Amino acid sequences are highly conserved between the two receptors (78% identity). The chromosomal loci of mTnfrh1 and mTnfrh2 genes are fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecb41f5af46f58db33f582fb630efe8e
https://doi.org/10.1038/emm.2003.21

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In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

Autor: Byungsuk Kwon, Soojin La, Eunhwa Kim

Publikováno v: Experimentalmolecular medicine. 37(3)

GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4(+)CD25(+) regulatory T cells and GITR signals break the suppressive activity of the subset. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913a2740ee33b96c6e2f568489ac324e
https://pubmed.ncbi.nlm.nih.gov/16000873

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Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses

Autor: Juyang Kim, Kack-Kyun Kim, Seok Hyun Nam, Sun Phil Choi, Soojin La, Jeong-Sun Seo, Byungsuk Kwon

Publikováno v: Experimentalmolecular medicine. 35(6)

4-1BB, a transmembrane molecule, member of the tumor necrosis factor receptor superfamily, is an important costimulatory molecule in the immune response, plays a key role in the clonal expansion and survival of CD8(+) T cells. In this study, we inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff01c9617838988255b48e94a941108
https://pubmed.ncbi.nlm.nih.gov/14749528

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Newly identified [correction of dentified] members of the TNF receptor superfamily (mTNFRH1 and mTNFRH2) inhibit T-cell proliferation

Autor: Juyang, Kim, Soojin, La, Byung-Sam, Kim, Byoung Se, Kwon, Byungsuk, Kwon

Publikováno v: Experimentalmolecular medicine. 35(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80efa64072a0e353e3c1a5aa7d9a49f9
https://pubmed.ncbi.nlm.nih.gov/12858013

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Herpes simplex virus type 1 glycoprotein D inhibits T-cell proliferation

Autor: Soojin, La, Juyang, Kim, Byoung S, Kwon, Byungsuk, Kwon

Publikováno v: Molecules and cells. 14(3)

Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) binds to its cellular receptor, herpesvirus entry mediator (HVEM), to enter into activated T cells. Since gD is expressed on the cell surface of activated T cells after infection and can interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::262bc999201990d330d9d03867d923ed
https://pubmed.ncbi.nlm.nih.gov/12521303

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