Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Soochul Shin"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-6 (2022)
The high-speed single-molecule miRNA detection technique dynamic FRET-FISH shows increased detection speed and high target specificity, detecting a single miRNA in ten seconds.
Externí odkaz:
https://doaj.org/article/a820953973b047e692c7aaf367afbd12
Autor:
Soochul Shin, Yoonseok Jung, Heesoo Uhm, Minseok Song, Soomin Son, Jiyoung Goo, Cherlhyun Jeong, Ji-Joon Song, V. Narry Kim, Sungchul Hohng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
MicroRNAs are potentially powerful biomarkers, though clinical use requires rapid and reliable profiling. Here the authors report amplification-free multicolour single-molecule imaging with single base mismatch sensitivity.
Externí odkaz:
https://doaj.org/article/a1f97de236b54183ad3bf6dbebd4a004
Publikováno v:
Cell Reports, Vol 23, Iss 6, Pp 1831-1839 (2018)
Summary: Replication fork reversal is one of the major pathways for reactivating stalled DNA replication. Many enzymes with replication fork reversal activity have DNA-unwinding activity as well, but none of the fork reversal enzymes in the SWI/SNF f
Externí odkaz:
https://doaj.org/article/9060bba765b744658a2e1da344f1dded
Autor:
Soochul Shin, Kwangbeom Hyun, Jinwoo Lee, Dongwon Joo, Tomasz Kulikowicz, Vilhelm A Bohr, Jaehoon Kim, Sungchul Hohng
Publikováno v:
Nucleic acids research.
The determination of the oligomeric state of functional enzymes is essential for the mechanistic understanding of their catalytic activities. RecQ helicases have diverse biochemical activities, but it is still unclear how their activities are related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdcd190fda95d6cf0ca87fa11f5e045
https://pubmed.ncbi.nlm.nih.gov/36583333
https://pubmed.ncbi.nlm.nih.gov/36583333
Autor:
Soochul Shin, Jaewon Kirk, Chanshin Kang, Ju Yeon Lee, Ye-Jin Lee, Eunhye Lee, Sungchul Hohng, Ji-Joon Song
Publikováno v:
Biochemistry. 59(47)
Chromodomain-helicase-DNA-binding protein 1 (CHD1) remodels chromatin by translocating nucleosomes along DNA, but its mechanism remains poorly understood. We use single-molecule fluorescence experiments to clarify the mechanism by which yeast CHD1 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39ff0bfd1eb0ab350af1f9a323be309
https://pubmed.ncbi.nlm.nih.gov/33174727
https://pubmed.ncbi.nlm.nih.gov/33174727
Autor:
Heesoo Uhm, Ji-Joon Song, Cherlhyun Jeong, Jiyoung Goo, Soomin Son, V. Narry Kim, Yoonseok Jung, Sungchul Hohng, Soochul Shin, Minseok Song
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the expression of protein coding genes at the post-transcriptional level. Differential expression profiles of miRNAs across a range of diseases have emerged as powerful biomarker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84369d3732f93eecee200b20424d4735
http://europepmc.org/articles/PMC7699633
http://europepmc.org/articles/PMC7699633
Publikováno v:
Bulletin of the Korean Chemical Society. 39:167-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e32b4ccbdfd6c81df62d1770f39bb5da
https://doi.org/10.1002/bkcs.11362
https://doi.org/10.1002/bkcs.11362
Autor:
Kyung-Won Min, Sungchul Hohng, Sylvia Davila, Soo Im Kang, Je-Hyun Yoon, Soochul Shin, Richard W. Zealy, Myung Hyun Jo, Lawson T. Lloyd
Publikováno v:
Nucleic Acids Research
Eukaryotic mRNA decay is tightly modulated by RNA-binding proteins (RBPs) and microRNAs (miRNAs). RBP AU-binding factor 1 (AUF1) has four isoforms resulting from alternative splicing and is critical for miRNA-mediated gene silencing with a distinct p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e135e3df589be103f8e1ba5a8c2e90
https://doi.org/10.1093/nar/gkx149
https://doi.org/10.1093/nar/gkx149
Autor:
Tomasz Kulikowicz, Sungchul Hohng, Hee-Sun Hong, Jaewon Kirk, Byungchan Ahn, Mina Lee, Jae-Hoon Kim, Vilhelm A. Bohr, Soochul Shin, Kwang Beom Hyun, Heesoo Uhm
Publikováno v:
Nucleic Acids Research
RPA is known to stimulate the helicase activity of Werner syndrome protein (WRN), but the exact stimulation mechanism is not understood. We use single-molecule FRET and magnetic tweezers to investigate the helicase activity of WRN and its stimulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def3ff657369f29ada64fc8d10379b02
https://doi.org/10.1093/nar/gky272
https://doi.org/10.1093/nar/gky272
Autor:
Sungchul Hohng, Sangwoon Yoo, Tomasz Kulikowicz, Jinwoo Lee, Soochul Shin, Byungchan Ahn, Vilhelm A. Bohr
Publikováno v:
Structure. 24:1292-1300
The reactivation of stalled DNA replication via fork regression invokes Holliday junction formation, branch migration, and the recovery of the replication fork after DNA repair or error-free DNA synthesis. The coordination mechanism for these DNA str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6329c2f53ef9eadde93ab22316c03f65
https://doi.org/10.1016/j.str.2016.06.004
https://doi.org/10.1016/j.str.2016.06.004