Results from UKALL60+, a phase 2 study in older patients with untreated acute lymphoblastic leukemia

Autor: Bela Patel, Amy A. Kirkwood, Clare J. Rowntree, Krisztina Z. Alapi, Emilio Barretta, Laura Clifton‐Hadley, Tom Creasey, SooWah Lee, David I. Marks, Anthony V. Moorman, Nicholas Morley, Pip Patrick, Zaynab Rana, Anita Rijneveld, John A. Snowden, Adele K. Fielding

Publikováno v: HemaSphere, Vol 8, Iss 6, Pp n/a-n/a (2024)

Externí odkaz: https://doaj.org/article/f8ed0d4f316040aaadab89e48c475ad0

Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial

Autor: David I Marks, Amy A Kirkwood, Clare J Rowntree, Melanie Aguiar, Katharine E Bailey, Brendan Beaton, Paul Cahalin, Anna Z Castleton, Laura Clifton-Hadley, Mhairi Copland, Anthony H Goldstone, Richard Kelly, Emma Lawrie, SooWah Lee, Andrew K McMillan, Mary Frances McMullin, Tobias F Menne, Rachel J Mitchell, Anthony V Moorman, Bela Patel, Pip Patrick, Paul Smith, David Taussig, Deborah Yallop, Krisztina Zuborne Alapi, Adele K Fielding

Publikováno v: Marks, D I, Kirkwood, A A, Rowntree, C J, Aguiar, M, Bailey, K E, Beaton, B, Cahalin, P, Castleton, A Z, Clifton-Hadley, L, Copland, M, Goldstone, A H, Kelly, R, Lawrie, E, Lee, S, McMillan, A K, McMullin, M F, Menne, T F, Mitchell, R J, Moorman, A V, Patel, B, Patrick, P, Smith, P, Taussig, D, Yallop, D, Alapi, K Z & Fielding, A K 2022, ' Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial ', The Lancet Haematology, vol. 9, no. 4, pp. e262-e275 . https://doi.org/10.1016/S2352-3026(22)00038-2

BACKGROUND: Treatment for adults with acute lymphoblastic leukaemia requires improvement. UKALL14 was a UK National Cancer Research Institute Adult ALL group study that aimed to determine the benefit of adding the anti-CD20 monoclonal antibody, ritux

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb76af476ccd2c9482ebad9b933c975
https://doi.org/10.1016/s2352-3026(22)00038-2

Diagnostic Utility of Whole Genome Sequencing in Adults with B-Other Acute Lymphoblastic Leukaemia

Autor: Daniel Leongamornlert, Jesús Gutiérrez-Abril, SooWah Lee, Emilio Barretta, Thomas Creasey, Krisztina Zuborne Alapi, Max F. Levine, Juan E Arango-Ossa, Juan S Medina-Martinez, Amy A. Kirkwood, Laura Clifton-Hadley, Pip Patrick, David Jones, Adam P Butler, Christine J. Harrison, Peter J. Campbell, Bela Patel Wrench, Anthony V. Moorman, Adele K. Fielding, Elli Papaemmanuil

Publikováno v: Blood. 140:6356-6357

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6b0d22d4d806e83087b06002626206
https://doi.org/10.1182/blood-2022-165985

Clinical utility of whole genome sequencing in hematological neoplasms

Autor: Jesus Gutierrez-Abril, Laura Clifton-Hadley, Anthony V. Moorman, Neerav Shukla, Yangyu Zhou, SooWah Lee, Amy A Kirkwood, Gunes Gundem, Pip Patrick, Juan E. Arango Ossa, Adele K. Fielding, Maria Luisa Sulis, Juan S. Medina-Martinez, Elli Papaemmanuil, Andrew L. Kung, Daniel Leongamornlert, Rachel J. Mitchell, Max Levine, Bela Wrench

Publikováno v: Journal of Clinical Oncology. 39:7028-7028

7028 Background: Hematological neoplasms are often characterized by acute onset and rapid disease progression. Cytogenetics, FISH, SNP arrays, targeted DNA and RNA sequencing are performed to inform diagnosis, risk stratification and guide treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6458d4e5f623f83016be52a9580a2843
https://doi.org/10.1200/jco.2021.39.15_suppl.7028