Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Soo-Young Yum"'
Autor:
Kyeong-hyeon Eom, Dong-hyeok Kwon, Young-chai Kim, Gyeong-min Gim, Soo-young Yum, Seong-Min Kim, Hyuk-Jin Cha, Goo Jang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Gene therapy is a promising method for treating inherited diseases by directly delivering the correct genetic material into patient cells. However, the limited packaging capacity of vectors poses a challenge. Minimizing promoter size is a vi
Externí odkaz:
https://doaj.org/article/45a279df0e6b43dc9b19095e3a5c75bd
Autor:
Gyeong-Min Gim, Kyeong-Hyeon Eom, Dong-Hyeok Kwon, Dae-Jin Jung, Dae-Hyun Kim, Jun-Koo Yi, Jae-Jung Ha, Ji-Hyun Lee, Seong-Beom Lee, Woo-Jae Son, Soo-Young Yum, Won-Wu Lee, Goo Jang
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Background Genome editing has been considered as powerful tool in agricultural fields. However, genome editing progress in cattle has not been fast as in other mammal species, for some disadvantages including long gestational periods, single
Externí odkaz:
https://doaj.org/article/988119c449bf4c978309fa26ff0bf2e4
Autor:
Junkoo Yi, Soo‐Young Yum, Daehyun Kim, Sera Han, Jaejung Ha, Jisu Kim, Daejin Jung, Goo Jang, Wonyou Lee, Joonho Moon
Publikováno v:
Veterinary Medicine and Science, Vol 8, Iss 3, Pp 1258-1263 (2022)
Abstract Background With unique genetic traits, Hanwoo cattle (Bos taurus coreanae) are well‐adapted to the Korean environment. However, their perinatal mortality rate is 2%–3%, which imposes an economic burden. Objective Due to insufficient data
Externí odkaz:
https://doaj.org/article/6a8925a8020349319e7426daca52d518
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Lineage tracing has provided new insights into cell fate but defining cellular diversity remains a challenge. Here the authors target endogenous repeat regions in mammalian cells with cytidine deaminase fused to nCas9 to create genetic barcodes for f
Externí odkaz:
https://doaj.org/article/59973f013a274b7f970aafea760c6a65
Autor:
Soo-Young Yum, Song-Jeon Lee, Sin-Gi Park, In-Gang Shin, Sang-Eun Hahn, Woo-Jae Choi, Hee-Soo Kim, Hyeong-Jong Kim, Seong-Hun Bae, Je-Hyeong Lee, Joo-Yeong Moon, Woo-Sung Lee, Ji-Hyun Lee, Choong-Il Lee, Seong-Jin Kim, Goo Jang
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Transposon-mediated, non-viral gene delivery is a powerful tool for generating stable cell lines and transgenic animals. However, as multi-copy insertion is the preferred integration pattern, there is the potential for uncontrolle
Externí odkaz:
https://doaj.org/article/9be3e3af2b504247ba09eea587d9db96
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 9, Iss 1, Pp 1-9 (2018)
Abstract The production of transgenic farm animals (e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos
Externí odkaz:
https://doaj.org/article/efd00363b22941659a9b16bf4c111815
Publikováno v:
Animals, Vol 11, Iss 12, p 3570 (2021)
Multiplex genome editing may induce genotoxicity and chromosomal rearrangements due to double-strand DNA breaks at multiple loci simultaneously induced by programmable nucleases, including CRISPR/Cas9. However, recently developed base-editing systems
Externí odkaz:
https://doaj.org/article/138d5b51ca2a46bebe70395ef93d1810
Publikováno v:
Animal Biotechnology. :1-6
Gene integration at site-specific loci is a critical approach for understanding the function of a gene in cells or animals. The AAVS1 locus is a well-known safe harbor for human and mouse studies. In this study, we found an AAVS1-like sequence (pAAVS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb02ab71190d6a5d4b58b58ad49c6cc
https://doi.org/10.1080/10495398.2023.2187408
https://doi.org/10.1080/10495398.2023.2187408
Autor:
Gyeong-Min Gim, Kyeong-Hyun Uhm, Dong-Hyeok Kwon, Min-Ji Kim, Dae-Jin Jung, Dae-Hyun Kim, Jun-Koo Yi, Jae-Jung Ha, Soo-Young Yum, Woo-Jae Son, Ji-Hyun Lee, Ji-Hyun Park, Kil-Young Song, Won-Wu Lee, Goo Jang
Publikováno v:
Theriogenology. 192:22-27
Although the production of several founder animals (F0) for gene editing in livestock has been reported in cattle, very few studies have assessed germline transmission to the next generation due to the long sexual maturation and gestation periods. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe25c676a34268c61e81099142b251fc
https://doi.org/10.1016/j.theriogenology.2022.08.021
https://doi.org/10.1016/j.theriogenology.2022.08.021
Publikováno v:
Animals, Vol 11, Iss 3570, p 3570 (2021)
Animals : an Open Access Journal from MDPI
Animals : an Open Access Journal from MDPI
Simple Summary CRISPR/Cas9 driven multiplex genome editing may induce genotoxicity and chromosomal rearrangements due to DNA double-strand breaks at multiple loci simultaneously. To overcome this problem in porcine cells we utilized Target-AID, a bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914f744b599b8845c3e6639e38a4acb4
https://doi.org/10.20944/preprints202109.0362.v1
https://doi.org/10.20944/preprints202109.0362.v1
