Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Soo San Wan"'
Autor:
Carl R. Walkley, Kaylene J. Simpson, Michael A. Dyer, David C.S. Huang, Chris Burns, Andrew C.W. Zannettino, Piyush B. Madhamshettiwar, Jayesh Desai, Anthony J. Mutsaers, Åsa Karlström, Kurt Lackovic, Scott Taylor, Alistair M. Chalk, Cathryn M. Gould, Anang A. Shelat, Amos Loh, Elizabeth Stewart, Soo-San Wan, Emma K. Baker, Ankita Gupte
Purpose: Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significant improvements in patient survival have not been observed. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038b0bc2ae54a3ccfed107284bf17a8c
https://doi.org/10.1158/1078-0432.c.6523853.v1
https://doi.org/10.1158/1078-0432.c.6523853.v1
Autor:
Carl R. Walkley, Kaylene J. Simpson, Michael A. Dyer, David C.S. Huang, Chris Burns, Andrew C.W. Zannettino, Piyush B. Madhamshettiwar, Jayesh Desai, Anthony J. Mutsaers, Åsa Karlström, Kurt Lackovic, Scott Taylor, Alistair M. Chalk, Cathryn M. Gould, Anang A. Shelat, Amos Loh, Elizabeth Stewart, Soo-San Wan, Emma K. Baker, Ankita Gupte
Supplemental Material and Methods, Table 1, and Figures 1-7. Supplemental Table 1 - Primer Sequences used for qPCR. Supplemental Figure 1 - Suppressors of doxorubicin induced cell death from siRNA screen. Supplemental Figure 2 - Response to Spliceost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc1106dccb2b6c4fd3769199c668b33
https://doi.org/10.1158/1078-0432.22458170.v1
https://doi.org/10.1158/1078-0432.22458170.v1
Autor:
Mark F. van Delft, Meng Xiao Luo, Kate McArthur, Peter E. Czabotar, Jarrod J. Sandow, Laura F. Dagley, Kym N Lowes, Jason M. Brouwer, Andrew I. Webb, Guillaume Lessene, Rachael M. Lane, Keith G. Watson, Christoph Grohmann, Ahmad Wardak, Peter M. Colman, Sabrina Bernard, Soo San Wan, Yelena Khakham, Phillip P. Sharp, Romina Lessene, Thao Nguyen, David J. Segal, David C.S. Huang, Erinna F. Lee, Lucy Li, Marlyse A. Debrincat, Grant Dewson, Chinh T. Bui, Hui San Chin, W. Douglas Fairlie, Stephane Duflocq, Benjamin T. Kile, Stephane Chappaz, Caroline Miles, Kurt Lackovic, Laure Peilleron
Publikováno v:
Nature Chemical Biology. 15:1057-1066
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f8a84e9d19f8763b3963c4941664e3
https://doi.org/10.1038/s41589-019-0365-8
https://doi.org/10.1038/s41589-019-0365-8
Publikováno v:
Tetrahedron. 72:1151-1160
Several rationally designed pyrimidine-based scaffolds intended to mimic the spatial projection of the i, i+3, and i+7 residues of an α-helix and also possess improved aqueous solubility were prepared. A Biginelli-oxidation process was used to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eedd353ac0663a20cd824eb8695ceda2
https://doi.org/10.1016/j.tet.2015.12.044
https://doi.org/10.1016/j.tet.2015.12.044
Autor:
Mark A. Guthridge, Andrew H. Wei, David J. Segal, Tracy L. Nero, Melanie de Silva, Michael W. Parker, Christopher J. Burns, Soo San Wan, Louisa J. Phillipson
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:6280-6296
The serine-threonine kinase CDK9 is a target of emerging interest for the development of anti-cancer drugs. There are multiple lines of evidence linking CDK9 activity to cancer, including the essential role this kinase plays in transcriptional regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320f161d7b5b20cab63cb0f5d609ec23
https://doi.org/10.1016/j.bmc.2015.08.035
https://doi.org/10.1016/j.bmc.2015.08.035
Autor:
Mark F, van Delft, Stephane, Chappaz, Yelena, Khakham, Chinh T, Bui, Marlyse A, Debrincat, Kym N, Lowes, Jason M, Brouwer, Christoph, Grohmann, Phillip P, Sharp, Laura F, Dagley, Lucy, Li, Kate, McArthur, Meng-Xiao, Luo, Hui San, Chin, W Douglas, Fairlie, Erinna F, Lee, David, Segal, Stephane, Duflocq, Romina, Lessene, Sabrina, Bernard, Laure, Peilleron, Thao, Nguyen, Caroline, Miles, Soo San, Wan, Rachael M, Lane, Ahmad, Wardak, Kurt, Lackovic, Peter M, Colman, Jarrod J, Sandow, Andrew I, Webb, Peter E, Czabotar, Grant, Dewson, Keith G, Watson, David C S, Huang, Guillaume, Lessene, Benjamin T, Kile
Publikováno v:
Nature chemical biology. 15(11)
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0477b40e4e5384654fad1f5b446d351b
https://pubmed.ncbi.nlm.nih.gov/31591564
https://pubmed.ncbi.nlm.nih.gov/31591564
Autor:
Wei Shi, Chin-Nien Lee, Irina Caminschi, Susie Kitsoulis, Scott N. Mueller, Andrew M. Lew, Ken Shortman, Soo San Wan, Gordon K. Smyth, David Vremec, Fatma Ahmet, Belinda Phipson, Yu Kato, Mireille H. Lahoud, Gayle M. Davey, William R. Heath
Publikováno v:
The Journal of Immunology. 187:842-850
Three surface molecules of mouse CD8+ dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b28ffd48d51adde026fdaa9fcf27441
https://doi.org/10.4049/jimmunol.1101176
https://doi.org/10.4049/jimmunol.1101176
Autor:
Michael Francis Harte, Cathy Malcontenti-Wilson, Mark Frazzetto, Rosa Fida, Irma Kruszelnicki, Neil Wilson, Rodney J. Dilley, Soo San Wan, Ian D Phillips, P. Bukczynska, Max Joffe, Susan A. Charman, Stephen Su, David M. Shackleford, Andrew F. Wilks, Yue Wang, Christopher J. Burns, Emmanuelle Fantino, Bing Wang
Publikováno v:
Molecular Cancer Therapeutics. 8:3036-3045
CYT997 is a wholly synthetic compound that possesses highly potent cytotoxic activity in vitro through inhibition of microtubule polymerization. CYT997 blocks the cell cycle at the G2-M boundary, and Western blot analysis indicates an increase in pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b50aebffc818e5cc6d0bda0445eb1ad
https://doi.org/10.1158/1535-7163.mct-09-0076
https://doi.org/10.1158/1535-7163.mct-09-0076
Autor:
Amos Hong Pheng Loh, Alistair M. Chalk, Michael A. Dyer, Kurt Lackovic, Piyush B Madhamshettiwar, Jayesh Desai, Carl R. Walkley, Kaylene J. Simpson, Ankita Gupte, David C.S. Huang, Cathryn M. Gould, Anang A. Shelat, Soo-San Wan, Anthony J. Mutsaers, Emma Baker, Andrew C.W. Zannettino, Elizabeth Stewart, Scott Taylor, Asa Karlstrom, Christopher J. Burns
Purpose: Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significant improvements in patient survival have not been observed. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548bb76fbbe632947b6f89dc70432754
https://acuresearchbank.acu.edu.au/item/8v632/systematic-screening-identifies-dual-pi3k-and-mtor-inhibition-as-a-conserved-therapeutic-vulnerability-in-osteosarcoma
https://acuresearchbank.acu.edu.au/item/8v632/systematic-screening-identifies-dual-pi3k-and-mtor-inhibition-as-a-conserved-therapeutic-vulnerability-in-osteosarcoma
Autor:
David Ian Rhodes, Susan Cox, Neville G. Walsh, Simon P. B. Ovenden, Jin Yu, R. Murray Tait, Barbara Meurer-Grimes, Gian Sberna, Soo San Wan, Jonathan Coates
Publikováno v:
Phytochemistry. 65:3255-3259
An HTS campaign aimed at the identification of inhibitors of HIV integrase showed that the methanol extract from the buds of a Eucalyptus globoidea was active. Bioassay guided fractionation of this extract resulted in the purification and structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa047bb2f10ee18438b3fb97d471a97c
https://doi.org/10.1016/j.phytochem.2004.10.006
https://doi.org/10.1016/j.phytochem.2004.10.006