Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Soo Jin, Oh"'
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Autor:
Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi Hwang, Junghee Lee, C. Justin Lee, Hoon Ryu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell aut
Externí odkaz:
https://doaj.org/article/10d1c6d648c04589a8cf3caf530fc135
Publikováno v:
eLife, Vol 12 (2024)
We studied lysosomal Ca2+ in inflammasome. Lipopolysaccharide (LPS) + palmitic acid (PA) decreased lysosomal Ca2+ ([Ca2+]Lys) and increased [Ca2+]i through mitochondrial ROS, which was suppressed in Trpm2-KO macrophages. Inflammasome activation and m
Externí odkaz:
https://doaj.org/article/993d8914d5574266965f2bfe90228eb9
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Viruses have evolved to control mitochondrial quality and content to facilitate viral replication. Mitophagy is a selective autophagy, in which the damaged or unnecessary mitochondria are removed, and thus considered an essential mechanism f
Externí odkaz:
https://doaj.org/article/946f507fdc52474daa603ebe8230c668
Autor:
Dong-hee Lee, Hyejin Ahn, Hye-In Sim, Eunji Choi, Seunghyun Choi, Yunju Jo, Bohwan Yun, Hyun Kyu Song, Soo Jin Oh, Kaori Denda-Nagai, Chan-Sik Park, Tatsuro Irimura, Yoon Park, Hyung-seung Jin
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Immunotherapy has significantly advanced cancer treatments, but many patients do not respond to it, partly due to immunosuppressive mechanisms used by tumor cells. These cells employ immunosuppressive ligands to evade detection an
Externí odkaz:
https://doaj.org/article/5a2155d0c9c541b7b2a52446c3747bb0
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 1922-1932 (2023)
Abstract Mitophagy is an excellent example of selective autophagy that eliminates damaged or dysfunctional mitochondria, and it is crucial for the maintenance of mitochondrial integrity and function. The critical roles of autophagy in pancreatic β-c
Externí odkaz:
https://doaj.org/article/1fd7e5447279472f9e0aad7e60ff275e
Autor:
Soo-Jin Oh, Pratima Kumari, Tabassum Tasnim Auroni, Shannon Stone, Heather Pathak, Amany Elsharkawy, Janhavi Prasad Natekar, Ok Sarah Shin, Mukesh Kumar
Publikováno v:
Pathogens, Vol 13, Iss 7, p 528 (2024)
Neurological manifestations are a significant complication of coronavirus disease 2019 (COVID-19), but the underlying mechanisms are yet to be understood. Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced neuroinvasion an
Externí odkaz:
https://doaj.org/article/5524bf98996146f7af444e189f4d951f
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Neurodegenerative diseases are explained by progressive defects of cognitive function and memory. These defects of cognition and memory dysfunction can be induced by the loss of brain-derived neurotrophic factors (BDNF) signaling. Paeonia la
Externí odkaz:
https://doaj.org/article/14ef7dfa2f8f4aabb628077b204cfd35
Autor:
Kihyoun Park, Injae Shin, Yoonseon Kim, Hyereen Kang, Soo-Jin Oh, Eunkyeong Jang, Taebo Sim, Jeehee Youn, Myung-Shik Lee
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundSince NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors could be employed as therapeutic agents against gout, a representative disease caused by NLRP3 inflammasome.MethodsWe designed NEK7 inhibitors based on biochemical ki
Externí odkaz:
https://doaj.org/article/e54b04d9a99a4f47b6bca4d955a248b0
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract While the mechanism of lipotoxicity by palmitic acid (PA), an effector of metabolic stress in vitro and in vivo, has been extensively investigated, molecular details of lipotoxicity are still not fully characterized. Since recent studies rep
Externí odkaz:
https://doaj.org/article/a8b36a5653754d94800383c4783f5021
Autor:
Elliot H. Lee, Jung-eun Park, Lizaveta Gotina, Young-Eun Han, Ambily Nath Indu Viswanath, Seonguk Yoo, Bongjin Moon, Jin-Young Hwang, Woo Kyu Park, Yoonjeong Cho, Chiman Song, Sun-Joon Min, Eun Mi Hwang, Hyunbeom Lee, Ae Nim Pae, Eun Joo Roh, Soo-Jin Oh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115139- (2023)
TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain potassium (K2p) channel and is widely expressed in the brain. TREK-1 knockout mice were shown to have antidepressant-like effects, providing evidence for the channel's pote
Externí odkaz:
https://doaj.org/article/e75576798c434684a9173742b6f0fcf7