Výsledky vyhledávání - "Soo Been Park"

Akademický článek

PUM1-TRAF3 fusion protein activates non-canonical NF-κB signaling via rescued NIK in biliary tract cancer

Autor: Dawoon E. Jung, Mi-Kyoung Seo, Jung Hyun Jo, Kahee Kim, Chanyang Kim, Hyundeok Kang, Soo Been Park, Hee Seung Lee, Sangwoo Kim, Si Young Song

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)

Abstract Discovery and verification of diagnostic or therapeutic biomarkers for biliary tract cancer (BTC) is challenging owing to the low prevalence of the disease. Here, we identified and investigated the clinical impact of a fusion gene, Pumilio1-

Externí odkaz: https://doaj.org/article/87b16b76ddf34dcdb212978e21fcc41d

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Akademický článek

Transgelin-2, a novel cancer stem cell-related biomarker, is a diagnostic and therapeutic target for biliary tract cancer

Autor: Jung Hyun Jo, Soo Been Park, Joowon Chung, Taeyun Oh, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Dawoon E. Jung, Si Young Song

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)

Abstract Background Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to

Externí odkaz: https://doaj.org/article/540fbdef04374f1dbacc19d8c197fc16

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Akademický článek

Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping

Autor: Hee Seung Lee, Dai Hoon Han, Kyungjoo Cho, Soo Been Park, Chanyang Kim, Galam Leem, Dawoon E. Jung, Soon Sung Kwon, Chul Hoon Kim, Jung Hyun Jo, Hye Won Lee, Si Young Song, Jun Yong Park

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

There is still need for representative models of intrahepatic cholangiocarcinoma (ICC) subtypes. Here, the authors develop organoids for two recently suggested ICC subtypes and identify distinct transcriptional profiles and potential therapeutic targ

Externí odkaz: https://doaj.org/article/c7ee9fb4b1f44eebb942674d6bedd86f

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Akademický článek

Phenotypic characteristics of circulating tumor cells and predictive impact for efficacy of chemotherapy in patients with pancreatic cancer: a prospective study

Autor: Hee Seung Lee, Eun Hye Jung, Hyejung Shin, Chan Su Park, Soo Been Park, Dawoon E. Jung, Galam Leem, So Jung Kim, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

ObjectiveEarly chemoresistance and tumor mass progression are associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Circulating tumor cells (CTCs) have been studied as potential predictors of treatment response and prognosis in P

Externí odkaz: https://doaj.org/article/3f4a2afb2ad5421490b2e5c03d611c7e

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Akademický článek

GLRX3, a novel cancer stem cell-related secretory biomarker of pancreatic ductal adenocarcinoma

Autor: Jung Hyun Jo, Sun A Kim, Jeong Hoon Lee, Yu Rang Park, Chanyang Kim, Soo Been Park, Dawoon E. Jung, Hee Seung Lee, Moon Jae Chung, Si Young Song

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021)

Abstract Background Cancer stem cells (CSCs) are implicated in carcinogenesis, cancer progression, and recurrence. Several biomarkers have been described for pancreatic ductal adenocarcinoma (PDAC) CSCs; however, their function and mechanism remain u

Externí odkaz: https://doaj.org/article/eb3af251a62c4c54b9cc1856215d522c

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Akademický článek

Identification of potential biomarkers for diagnosis of pancreatic and biliary tract cancers by sequencing of serum microRNAs

Autor: Kwondo Kim, DongAhn Yoo, Hee Seung Lee, Kyong Joo Lee, Soo Been Park, Chanyang Kim, Jung Hyun Jo, Dawoon E. Jung, Si Young Song

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-11 (2019)

Abstract Background Pancreatic and biliary tract cancer (PC and BTC, respectively) are difficult to diagnose because of their clinical characteristics; however, recent studies suggest that serum microRNAs (miRNAs) might be the key to developing more

Externí odkaz: https://doaj.org/article/1ebdc8fa78ba41d8b3d142125db43127

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