Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sonyuan Lin"'
Publikováno v:
Chemistry and Physics of Lipids. 113:111-122
Semi-preparative HPLC on a chiral stationary phase (Chiracel OD) was utilized in the course of this synthesis to separate the four possible diastereomers [cis-(2R,4S)-2a, trans-(2S,4S)-2b, cis-(2S,4R)-2a', and trans-(2R,4R)-2b'] of a 2,4-disubstitute
Publikováno v:
Behavioural Pharmacology. 11:81-86
Järbe et al. (1998a) trained rats to discriminate between (-)-delta9-tetrahydrocannabinol (delta9-THC) and vehicle, using different training doses in order to create assays with different efficacy demands, to examine whether (R)-methanandamide, an a
Autor:
S. John Gatley, Andreas Goutopoulos, Magalie Bruneus, Nora D. Volkow, Sonyuan Lin, Andrew N. Gifford, Alexandros Makriyannis
Publikováno v:
European Journal of Pharmacology. 383:9-14
The electrically-evoked release of [3H]acetylcholine from hippocampal brain slices is inhibited by cannabinoid receptor agonists. The effect of palmitylsulphonyl fluoride (AM 374), a recently developed inhibitor of fatty acid amide hydrolase, in infl
Autor:
Deirdre S. McCallion, Ruoxi Lan, Qian Liu, Pusheng Fan, Roger G. Pertwee, Alexandros Makriyannis, Sonyuan Lin, Susanthi R. Fernando
Publikováno v:
Journal of Medicinal Chemistry. 42:769-776
As a potent, specific antagonist for the brain cannabinoid receptor (CB1), the biarylpyrazole N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A; 1) was the lead compound for initiating studies
Autor:
Atmaram D. Khanolkar, Demetris Papahadjis, Andreas Goutopoulos, Ce Qin, Alexandros Makriyannis, Sonyuan Lin, Pusheng Fan
Publikováno v:
Journal of Medicinal Chemistry. 41:5353-5361
Several analogues of the endogenous cannabinoid receptor ligand arachidonylethanolamide (anandamide) were synthesized and evaluated in order to study (a) the structural requirements for high-affinity binding to the CB1 and CB2 cannabinoid receptors a
Publikováno v:
Chemistry and Physics of Lipids. 86:171-181
The syntheses of four head group labeled analogs of 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine (DPPC) (6) by a general method from 1,2-di-O-palmitoyl-sn-glycero-3-phosphatidic acid (5) have been performed. The syntheses of 1,2-di-O-palmitoyl-sn-g
Autor:
E. Theodoropoulou, Alexandros Makriyannis, Maria Koufaki, De-Ping Yang, Thomas Mavromoustakos, Sonyuan Lin
Publikováno v:
Chemistry and Physics of Lipids 84:1(Nov1996):21-34
Thio analogs of platelet activating factor (PAF) are of great interest because they exhibit antineoplastic properties both in vitro and in vivo. In contrast to most known anticancer agents, these lipids appear not to act through the synthesis and fun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1283(1):111-118
The ether lipid analogs ( R )-PAF, ( R )-ET-18-OMe and ( R )-Lyso-PAF can form bilayers. Using differential scanning calorimetry (DSC) and small angle X-ray diffraction, we have investigated bilayers formed entirely of these molecules. Small angle X-
Autor:
Sonyuan Lin, William Adam Hill, Khaled A.M. Abouzid, Vasiliki Abadji, Atmaram D. Khanolkar, Alexandros Makriyannis, Zhaoxing Meng, G. Taha, Pusheng Fan
Publikováno v:
Journal of Medicinal Chemistry. 39:4515-4519
Several analogs of an endogenous cannabimimetic, arachidonylethanolamide (anandamide), were synthesized to study the structural requirements of the ethanolamide head group. CB1 receptor affinities of the analogs were evaluated by a standard receptor
Autor:
Lesley A. Stevenson, Alexandros Makriyannis, Roger G. Pertwee, Graeme Griffin, Sonyuan Lin, G. Taha, Vasiliki Abadji
Publikováno v:
Scopus-Elsevier
Four chiral congeners of arachidonylethanolamide (anandamide) have been synthesized and evaluated for (a) their ability to bind to the cannabinoid receptor in rat forebrain membranes and (b) their pharmacological potency as measured by the compounds'