Výsledky vyhledávání - "Sonya Kwiatkowski"

Supplementary Figure Legends from Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Autor: Michael A. Caligiuri, Pierluigi Porcu, James E. Bradner, Guido Marcucci, Jianying Zhang, Giandomenico Russo, Henry Wong, Jun Qi, Kathleen McConnell, Jing Wen, Douglas P. Curphey, Jessica Johns, Gregory H. Sams, Laura A. Sullivan, Sonya Kwiatkowski, Krista La Perle, Anjali Mishra

Supplementary Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b60f80a8660e654c83ba66309b3345f0
https://doi.org/10.1158/2159-8290.22531313

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Supplementary Table 1 from Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Supplementary Table 1A (ST1A). Clinical features of CTCL (MF and SS) patients used in Figure 1B and Figure 4E (denoted with *). Stage 1B and IIB are MF samples and Stage III/IV are SS samples. Supplementary Table 1B (ST1B). Clinical features of SS pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226f3268ab045c38e650c88d8984100c
https://doi.org/10.1158/2159-8290.22531307

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Supplementary Figure Legends from Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Supplementary Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0160d63850090e68dc0b288196f3d2be
https://doi.org/10.1158/2159-8290.22531313.v1

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Supplementary Table Legend from Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Supplementary Table Legend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27ae94978be9b97de2cf9d43312c238
https://doi.org/10.1158/2159-8290.22531304.v1

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Supplementary Figures 1 - 7 from Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Supplementary Figures 1 - 7. Supplementary Figure 1. Immunoblot analysis of IL-15 in normal donor CD4+ T-cells, SS patient CD4+ T-cells and patient derived cell lines. Supplementary Figure 2. Representative flow cytometric histogram is shown for CD3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25df333b1792834ceba1ee18b96a28e3
https://doi.org/10.1158/2159-8290.22531310.v1

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Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Autor: Giandomenico Russo, Jianying Zhang, Douglas P. Curphey, Guido Marcucci, Henry K. Wong, Jessica Johns, Gregory H. Sams, James E. Bradner, Laura Sullivan, Jing Wen, Anjali Mishra, Michael A. Caligiuri, Jun Qi, Krista M. D. La Perle, Pierluigi Porcu, Kathleen McConnell, Sonya Kwiatkowski

Publikováno v: Cancer discovery. 6(9)

Cutaneous T-cell lymphoma (CTCL) is the most common type of primary cutaneous lymphoma. Here, we report that patients with CTCL show increased IL15 in a clinical stage–dependent manner. Mechanistically, we show that ZEB1 is a transcriptional repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717e060c7ae3f5786c1231752967465e
https://pubmed.ncbi.nlm.nih.gov/27422033

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Epigenetic Disruption of ZEB1 Binding Causes Constitutive Activation of IL-15 in Cutaneous T-Cell Lymphoma

Autor: Giandomenico Russo, Sonya Kwiatkowski, Pierluigi Porcu, Laura Sullivan, Michael A. Caligiuri, Anjali Mishra, Leah Grinshpun

Publikováno v: Blood. 126:3635-3635

Cutaneous T-cell lymphoma (CTCL) is a non-Hodgkin's lymphoma of skin-homing T-cells that represents 70-80% of all cutaneous lymphomas. Studies have shown that interleukin-15 (IL-15) plays a key role in T-cell oncogenesis by increasing T-cell survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7302c9d7efe5ae66265db6ed313588ed
https://doi.org/10.1182/blood.v126.23.3635.3635

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Genome-Wide Mapping Reveals BRD4 in Regulation of Tumor-Driver Genes in Cutaneous T-Cell Lymphoma

Autor: Laura Sullivan, Leah Grinshpun, Jun Qi, Alex S. Hartlage, James E. Bradner, Anjali Mishra, Michael A. Caligiuri, Pierluigi Porcu, Sonya Kwiatkowski

Publikováno v: Blood. 126:589-589

Cutaneous T-cell lymphoma (CTCL) is a non-Hodgkin's lymphoma of skin homing malignant CD4+ T cells. Early treatment of patients with skin-directed therapies often yields successful short-term outcomes; however, survival of patients with late-stage CT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b9e7d5334469202730be91c26335f61
https://doi.org/10.1182/blood.v126.23.589.589

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