Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sonya Gales"'
Autor:
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index
Externí odkaz:
https://doaj.org/article/722de1f4d6464ec9a94bce51fe4fc356
Autor:
Aatman S. Doshi, Susan Cantin, Marylens Hernandez, Srimathi Srinivasan, Sharon Tentarelli, Matthew Griffin, Yanjun Wang, Petar Pop-Damkov, Laura B. Prickett, Cecilia Kankkonen, Minhui Shen, Maryann San Martin, Song Wu, M. Paola Castaldi, Hormas Ghadially, Jeffrey Varnes, Sonya Gales, David Henry, Clare Hoover, Deanna A. Mele, Iain Simpson, Eric T. Gangl, Scott N. Mlynarski, M. Raymond V. Finlay, Lisa Drew, Stephen E. Fawell, Wenlin Shao, Alwin G. Schuller
Publikováno v:
Molecular Cancer Therapeutics. 22:630-645
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d755494151ffe43d642a50fe0b9dc5
https://doi.org/10.1158/1535-7163.mct-22-0431
https://doi.org/10.1158/1535-7163.mct-22-0431
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3d060f84133f3a377e582a99492b60
https://doi.org/10.1158/1535-7163.22758750.v1
https://doi.org/10.1158/1535-7163.22758750.v1
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18665fc75233d45f4d0523f70cb00720
https://doi.org/10.1158/1535-7163.22758747.v1
https://doi.org/10.1158/1535-7163.22758747.v1
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccec8976253039fecbf30710253ac110
https://doi.org/10.1158/1535-7163.c.6611322
https://doi.org/10.1158/1535-7163.c.6611322
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0b686af167082c71a1e1decc2974a2
https://doi.org/10.1158/1535-7163.22758741
https://doi.org/10.1158/1535-7163.22758741
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0a4ba3b70665b4722e1db7275ca66d
https://doi.org/10.1158/1535-7163.22758756
https://doi.org/10.1158/1535-7163.22758756
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f64dbe48f288949778ce78043663634
https://doi.org/10.1158/1535-7163.22674513
https://doi.org/10.1158/1535-7163.22674513
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6e24a72197858511a0f01c1563cae5
https://doi.org/10.1158/1535-7163.22674522.v1
https://doi.org/10.1158/1535-7163.22674522.v1
Autor:
Ammar Adam, David J. Owen, Justin Cidado, Claire Patterson, Matthew Skinner, Stuart Purbrick, Lorraine Graham, Petar Pop-Damkov, Michael Giannis, Srividya B. Balachander, Francis D. Gibbons, William McCoull, Marianne Ashford, Hill Kathryn Jane, Martin Wild, Eric Gangl, Stephen Fawell, Corinne Reimer, Sean Redmond, Paul D. Kemmitt, Barry R. Davies, Jamal Carlos Saeh, Shenghua Wen, J. Paul Secrist, Alwin Schuller, Edward J. Hennessy, Sonya Gales, Iain Grant, Alexander R. Harmer, Jeremy S. Parker, Brian Kelly
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Dual Bcl-2/Bcl-xL inhibitors are expected to deliver therapeutic benefit in many haematological and solid malignancies, however, their use is limited by tolerability issues. AZD4320, a potent dual Bcl-2/Bcl-xL inhibitor, has shown good efficacy howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f928851dba9fe7a39b683d8c12e8a5d
https://doi.org/10.1038/s42003-020-01631-8
https://doi.org/10.1038/s42003-020-01631-8