Výsledky vyhledávání - "Sonya C. Bardswell"

Akademický článek

Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement

Autor: Daniel Brayson, So‐Jin Holohan, Sonya C. Bardswell, Matthew Arno, Han Lu, Hanna K. Jensen, Phan Kiet Tran, Javier Barallobre‐Barreiro, Manuel Mayr, Cristobal G. dos Remedios, Victor T. Tsang, Alessandra Frigiola, Jonathan C. Kentish

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 16 (2020)

Background Patients with repair of tetralogy of Fallot (rToF) who are approaching adulthood often exhibit pulmonary valve regurgitation, leading to right ventricle (RV) dilatation and dysfunction. The regurgitation can be corrected by pulmonary valve

Externí odkaz: https://doaj.org/article/9b352784f7f947f58b51bb7e70bafd99

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Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Autor: Florian Weinberger, Jonathan C. Kentish, Nicolas Vignier, Sonya C. Bardswell, Bodvael Fraysse, Lucie Carrier, Elisabeth Krämer, Friederike Cuello, Catherine Coirault, Thomas Eschenhagen, Metin Avkiran, Jutta Starbatty, Birgit Geertz

Publikováno v: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology; Vol 52

Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in MYBPC3 encoding cardiac myosin-binding protein C (cMyBP-C). The mechanisms leading from gene mutations to the HCM phenotype remain incompletely understood, partially because curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548ca634163a56e2c1bbe24c09f9d1eb
https://doi.org/10.1016/j.yjmcc.2012.03.009

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Esmolol cardioplegia: the cellular mechanism of diastolic arrest

Autor: Jonathan C. Kentish, Hazem B. Fallouh, Linda M. McLatchie, Sonya C. Bardswell, Michael J. Shattock, David J. Chambers

Publikováno v: Cardiovascular Research. 87:552-560

Esmolol, an ultra-short-acting beta-blocker, acts as a cardioplegic agent at millimolar concentrations. We investigated the mechanism by which esmolol induces diastolic ventricular arrest.In unpaced Langendorff-perfused rat hearts, esmolol (0.03-3 mm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69792d553cce78bae71b6f739870638f
https://doi.org/10.1093/cvr/cvq058

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Distinct Sarcomeric Substrates Are Responsible for Protein Kinase D-mediated Regulation of Cardiac Myofilament Ca2+ Sensitivity and Cross-bridge Cycling

Autor: Jeffery W. Walker, Friederike Cuello, Jeffrey Robbins, Alexandra J. Rowland, Metin Avkiran, Sonya C. Bardswell, Jonathan C. Kentish, Mathias Gautel, Sakthivel Sadayappan

Publikováno v: Journal of Biological Chemistry. 285:5674-5682

Protein kinase D (PKD), a serine/threonine kinase with emerging cardiovascular functions, phosphorylates cardiac troponin I (cTnI) at Ser(22)/Ser(23), reduces myofilament Ca(2+) sensitivity, and accelerates cross-bridge cycle kinetics. Whether PKD re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdde1071ba0d476312f5926db8d4d27
https://doi.org/10.1074/jbc.m109.066456

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Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: A role for ER stress?

Autor: Sonya C. Bardswell, Metin Avkiran, Gajen Kanaganayagam, Stefan Engelhardt, Michael S. Marber, Subashini Pretheshan, Rita I. Jabr, Alexandra R. Cook, Sabine Merkle, K Dighe

Publikováno v: Journal of Molecular and Cellular Cardiology. 46:225-233

Sarcolemmal Na(+)/H(+) exchanger (NHE) activity, which is provided by the NHE isoform 1 (NHE1), has been implicated in ischemia/reperfusion-induced myocardial injury in animal models and humans, on the basis of studies with pharmacological NHE1 inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8021c209d57e02ca749813259166097f
https://doi.org/10.1016/j.yjmcc.2008.10.013

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Protein Kinase D Selectively Targets Cardiac Troponin I and Regulates Myofilament Ca 2+ Sensitivity in Ventricular Myocytes

Autor: Susanne Lutz, Robert S. Haworth, Sonya C. Bardswell, Metin Avkiran, Jonathan C. Kentish, Thomas Wieland, Friederike Cuello, Xiaoke Yin, Manuel Mayr

Publikováno v: Circulation Research. 100:864-873

Protein kinase D (PKD) is a serine/threonine kinase with emerging myocardial functions; in skinned adult rat ventricular myocytes (ARVMs), recombinant PKD catalytic domain phosphorylates cardiac troponin I at Ser22/Ser23 and reduces myofilament Ca 2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89afdfaecdb5d655e5842e45cd839060
https://doi.org/10.1161/01.res.0000260809.15393.fa

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Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation

Autor: Joseph R. Burgoyne, William Fuller, Shajna Begum, Jonathan C. Kentish, Robin Wait, Jonathan P. Brennan, Sonya C. Bardswell, Philip Eaton, Ewald Schröder

Publikováno v: Journal of Biological Chemistry. 281:21827-21836

Here we demonstrate that type I protein kinase A is redoxactive, forming an interprotein disulfide bond between its two regulatory RI subunits in response to cellular hydrogen peroxide. This oxidative disulfide formation causes a subcellular transloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a363dfdf068578dd61269bf11c5f0da7
https://doi.org/10.1074/jbc.m603952200

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Role for Nuclear Factor-κB and Signal Transducer and Activator of Transcription 1/Interferon Regulatory Factor-1 in Cytokine-Induced Endothelin-1 Release in Human Vascular Smooth Muscle Cells

Autor: Elizabeth G. Wood, Timothy D. Warner, SJ Wort, Stewart Barker, Sonya C. Bardswell, David Bishop-Bailey, Mandy Woods, Jane Mitchell

Publikováno v: Molecular Pharmacology. 64:923-931

Endothelin-1 (ET-1) is a potent vasoconstrictor and growth-promoting mediator that is involved in the maintenance of vascular tone within the healthy circulation. However, a pathogenic role has been implicated by its overproduction in a number of car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099c5a67a7f9b554bf238b8f4e9df557
https://doi.org/10.1124/mol.64.4.923

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cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance

Autor: Sonya C. Bardswell, Friederike Cuello, Metin Avkiran, Jonathan C. Kentish

Publikováno v: Journal of muscle research and cell motility. 33(1)

It is now generally accepted that phosphorylation of cMyBP-C is critically important in maintaining normal cardiac function. Although much of the work to date on phospho-regulation of cMyBP-C has focused on the role of protein kinase A (PKA, also kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a64a1a2f09bd268ae3b269393049886
https://pubmed.ncbi.nlm.nih.gov/22089698

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Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation

Autor: Sonya C. Bardswell, Friederike Cuello, Robert S. Haworth, Jonathan C. Kentish, Metin Avkiran, Elisabeth Ehler, Sakthivel Sadayappan

Publikováno v: The Journal of biological chemistry. 286(7)

In myocardium, the 90-kDa ribosomal S6 kinase (RSK) is activated by diverse stimuli and regulates the sarcolemmal Na(+)/H(+) exchanger through direct phosphorylation. Only limited information is available on other cardiac RSK substrates and functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33e246650ccf223706072461b4bcea2
https://pubmed.ncbi.nlm.nih.gov/21148481

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