Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Sonya A. Macparland"'
Autor:
Gregory M. Kent, Michael H. Atkins, Bryan Lung, Adele Nikitina, Ian M. Fernandes, Jamie J. Kwan, Tallulah S. Andrews, Sonya A. MacParland, Gordon M. Keller, Blair K. Gage
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114629- (2024)
Summary: In mice, the first liver-resident macrophages, known as Kupffer cells (KCs), are thought to derive from yolk sac (YS) hematopoietic progenitors that are specified prior to the emergence of the hematopoietic stem cell (HSC). To investigate hu
Externí odkaz:
https://doaj.org/article/02df4a49d2314ca5a9d8b39bd4826aa0
Autor:
Caitriona M. McEvoy, Julia M. Murphy, Lin Zhang, Sergi Clotet-Freixas, Jessica A. Mathews, James An, Mehran Karimzadeh, Delaram Pouyabahar, Shenghui Su, Olga Zaslaver, Hannes Röst, Rangi Arambewela, Lewis Y. Liu, Sally Zhang, Keith A. Lawson, Antonio Finelli, Bo Wang, Sonya A. MacParland, Gary D. Bader, Ana Konvalinka, Sarah Q. Crome
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Knowledge of the transcriptional programs of human kidney cell populations at homeostasis is limited. Here, the authors show sex-based differences in gene expression of kidney parenchymal cells and examine the complexity of kidney-resident immune cel
Externí odkaz:
https://doaj.org/article/fe8594c88fdd42d5869600c16f1e2141
Autor:
Tallulah S. Andrews, Jawairia Atif, Jeff C. Liu, Catia T. Perciani, Xue‐Zhong Ma, Cornelia Thoeni, Michal Slyper, Gökcen Eraslan, Asa Segerstolpe, Justin Manuel, Sai Chung, Erin Winter, Iulia Cirlan, Nicholas Khuu, Sandra Fischer, Orit Rozenblatt‐Rosen, Aviv Regev, Ian D. McGilvray, Gary D. Bader, Sonya A. MacParland
Publikováno v:
Hepatology Communications, Vol 6, Iss 4, Pp 821-840 (2022)
The critical functions of the human liver are coordinated through the interactions of hepatic parenchymal and non‐parenchymal cells. Recent advances in single‐cell transcriptional approaches have enabled an examination of the human liver with unp
Externí odkaz:
https://doaj.org/article/f4baa4210df8450382ddc9b9cbc1c1e2
Autor:
June Li, Danielle Karakas, Feng Xue, Yingyu Chen, Guangheng Zhu, Yeni H. Yucel, Sonya A. MacParland, Haibo Zhang, John W. Semple, John Freedman, Qizhen Shi, Heyu Ni
Publikováno v:
Research, Vol 6 (2023)
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of pla
Externí odkaz:
https://doaj.org/article/d855d9b595ef481e9037018204a124a5
Autor:
Sonya A. MacParland, Jeff C. Liu, Xue-Zhong Ma, Brendan T. Innes, Agata M. Bartczak, Blair K. Gage, Justin Manuel, Nicholas Khuu, Juan Echeverri, Ivan Linares, Rahul Gupta, Michael L. Cheng, Lewis Y. Liu, Damra Camat, Sai W. Chung, Rebecca K. Seliga, Zigong Shao, Elizabeth Lee, Shinichiro Ogawa, Mina Ogawa, Michael D. Wilson, Jason E. Fish, Markus Selzner, Anand Ghanekar, David Grant, Paul Greig, Gonzalo Sapisochin, Nazia Selzner, Neil Winegarden, Oyedele Adeyi, Gordon Keller, Gary D. Bader, Ian D. McGilvray
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
The development of single cell RNA sequencing technologies has been instrumental in advancing our understanding of tissue biology. Here, MacParland et al. performed single cell RNA sequencing of human liver samples, and identify distinct populations
Externí odkaz:
https://doaj.org/article/1f94e426277d4380b84494f20eaee742
Autor:
J. Javier Diaz-Mejia, Elaine C. Meng, Alexander R. Pico, Sonya A. MacParland, Troy Ketela, Trevor J. Pugh, Gary D. Bader, John H. Morris
Publikováno v:
F1000Research, Vol 8 (2019)
Background: Identification of cell type subpopulations from complex cell mixtures using single-cell RNA-sequencing (scRNA-seq) data includes automated steps from normalization to cell clustering. However, assigning cell type labels to cell clusters i
Externí odkaz:
https://doaj.org/article/25cf40df8e1541cc95186df61d5529c0
Autor:
J. Javier Diaz-Mejia, Elaine C. Meng, Alexander R. Pico, Sonya A. MacParland, Troy Ketela, Trevor J. Pugh, Gary D. Bader, John H. Morris
Publikováno v:
F1000Research, Vol 8 (2019)
Background: Identification of cell type subpopulations from complex cell mixtures using single-cell RNA-sequencing (scRNA-seq) data includes automated steps from normalization to cell clustering. However, assigning cell type labels to cell clusters i
Externí odkaz:
https://doaj.org/article/0def3835ecdf403a8ce61e0e86949cc6
Publikováno v:
Cells, Vol 8, Iss 4, p 317 (2019)
Worldwide, 71 million individuals are chronically infected with Hepatitis C Virus (HCV). Chronic HCV infection can lead to potentially fatal outcomes including liver cirrhosis and hepatocellular carcinoma. HCV-specific immune responses play a major r
Externí odkaz:
https://doaj.org/article/48486d5df68b45fd9b5fd7bd3d717275
Autor:
Nicholas van Buuren, Lorraine Fradette, Jason Grebely, Alexandra King, Mel Krajden, Sonya A. MacParland, Alison Marshall, Sahar Saeed, Joyce Wilson, Marina B. Klein, Selena M. Sagan
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2016 (2016)
Hepatitis C virus (HCV) affects approximately 268,000 Canadians and results in more years of life lost than any other infectious disease in the country. Both the Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PH
Externí odkaz:
https://doaj.org/article/444083c0ca1e403ba5aa243cf46c6c9e
Autor:
Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2016 (2016)
Hepatitis C virus (HCV) affects at least 268,000 Canadians and causes greater disease burden than any other infectious disease in the country. The Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PHAC) have identi
Externí odkaz:
https://doaj.org/article/e18bd4232f7c4c27a0ff92cf23147dcc