DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.

Autor: Milana Koulintchenko, Sonya Vengrova, Trevor Eydmann, Prakash Arumugam, Jacob Z Dalgaard

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47091 (2012)

Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switc

Externí odkaz: https://doaj.org/article/d5f5c9be195749eab721d92029a818b0

RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching

Autor: Jacob Z. Dalgaard, Sonya Vengrova

Publikováno v: Genes & Development. 18:794-804

Mating-type switching in fission yeast depends on an imprint at the mat1 locus. Previous data showed that the imprint is made in the DNA strand replicated as lagging. We now identify this imprint as an RNase-sensitive modification and suggest that it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56285228b20a89c7ba5bb99f23899f1
https://doi.org/10.1101/gad.289404

Comparative Functional Genomics of the Fission Yeasts

Autor: Jenna Pfiffner, Manolis Kellis, Jonathan M. Goldberg, Hironori Niki, Hanah Margalit, Sean M. Sykes, Michael Fitzgerald, Courtney French, Brian J. Haas, Ryan J. Yoder, Lin Fan, Peter Swoboda, David C. Baulcombe, Yabin Guo, Matthew W. Vaughn, Janet Leatherwood, Carolin A. Müller, Agata Smialowska, Keita Aoki, Barbara Robbertse, Sharvari Gujja, Bruce W. Birren, Joshua Z. Levin, Rebecca A. Mosher, Naomi Habib, Sonya Vengrova, Edward Dobbs, Robert A. Martienssen, David I. Heiman, Karl Ekwall, William Brown, Ilan Wapinski, Jacob Z. Dalgaard, Sushmita Roy, Livio Dukaj, Aviv Regev, Carsten Russ, Moran Yassour, Margaret Priest, Chad Nusbaum, Qiandong Zeng, Christopher A. Desjardins, Elizabeth H. Bayne, Kanji Furuya, Huei Mei Chen, Aaron M. Berlin, Alison L. Pidoux, Henry L. Levin, Peter Baumann, Zehua Chen, Dawn Thompson, Conrad A. Nieduszynski, Robin C. Allshire, Klavs R. Hansen, Daniel Keifenheim, Michael F. Lin, Nicholas Rhind, Nir Friedman, Joseph W. Spatafora, Sarah Young

Publikováno v: Rhind, N, Chen, Z, Yassour, M, Thompson, D A, Haas, B J, Habib, N, Wapinski, I, Roy, S, Lin, M F, Heiman, D I, Young, S K, Furuya, K, Guo, Y, Pidoux, A, Chen, H M, Robbertse, B, Goldberg, J M, Aoki, K, Bayne, E H, Berlin, A M, Desjardins, C A, Dobbs, E, Dukaj, L, Fan, L, FitzGerald, M G, French, C, Gujja, S, Hansen, K, Keifenheim, D, Levin, J Z, Mosher, R A, Mueller, C A, Pfiffner, J, Priest, M, Russ, C, Smialowska, A, Swoboda, P, Sykes, S M, Vaughn, M, Vengrova, S, Yoder, R, Zeng, Q, Allshire, R, Baulcombe, D, Birren, B W, Brown, W, Ekwall, K, Kellis, M, Leatherwood, J, Levin, H, Margalit, H, Martienssen, R, Nieduszynski, C A, Spatafora, J W, Friedman, N, Dalgaard, J Z, Baumann, P, Niki, H, Regev, A & Nusbaum, C 2011, ' Comparative Functional Genomics of the Fission Yeasts ', Science, vol. 332, no. 6032, pp. 930-936 . https://doi.org/10.1126/science.1203357

The fission yeast clade-comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus-occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d509aa1a29c380a8a809f9f1eee3a1a7
https://www.pure.ed.ac.uk/ws/files/7507857/NIH_2011_Allshire.pdf

Random and site-specific replication termination

Autor: Jacob Z, Dalgaard, Trevor, Eydmann, Milana, Koulintchenko, Suha, Sayrac, Sonya, Vengrova, Tomoko, Yamada-Inagawa

Publikováno v: Methods in molecular biology (Clifton, N.J.). 521

Bi-directionality is a common feature observed for genomic replication for all three phylogenetic kingdoms: Eubacteria, Archaea, and Eukaryotes. A consequence of bi-directional replication, where the two replication forks initiated at an origin move

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d2b32c11ff80b9488f755fe5a648329
https://pubmed.ncbi.nlm.nih.gov/19563100

High-Resolution Mapping of Points of Site-Specific Replication Stalling

Autor: Jacob Z. Dalgaard, Sonya Vengrova

Publikováno v: Methods in Molecular Biology ISBN: 9781603278140

Genetic instability due to stalled replication forks is thought to underlie a number of human diseases, such as premature ageing and cancer susceptibility syndromes. In addition, site-specific stalling occurs at some genetic loci. A detailed understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6b9d738f81b9c0e873fe0c8f3effaa2
https://doi.org/10.1007/978-1-60327-815-7_12