Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sony S. Rocha"'
Autor:
Steven E Kauder, Tracy C Kuo, Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Sony S Rocha, Sangeetha Bollini, Bora Han, Janet Sim, Jaume Pons, Hong I Wan
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201832 (2018)
CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune function
Externí odkaz:
https://doaj.org/article/3ebc34039c37468dbf22b9ca99bbcb93
Autor:
Laura B. Valenzuela, Chi-Heng Wu, Wade Aaron, Raphalea R. Banzon, Mabel Bush, S. Jack Lin, Sony S. Rocha, Subramanian Thothathri, Holger Wesche, Mary Ellen Molloy, Banmeet S. Anand
Publikováno v:
Cancer Research. 83:5070-5070
TriTAC® is a T cell engager platform comprised of three binding domains: a target binder for tumor cell engagement, an albumin binder for half-life extension, and a CD3 binder for T cell engagement. HPN328 is a Delta-like ligand 3 (DLL3)-targeting T
Autor:
Regina J. Lin, Sony S. Rocha, Maria R. Dayao, Subramanian Thothathri, Raphaela Rose Banzon, Kevin J. Wright, Wade Aaron, Yinghua Xiao, Nick Bergo, Linh To, Mabel Bush, Manasi Barath, Yi Yang, Timothy Yu, Willis Kwong, Hubert Situ, Eric Bragg, Jessica O'Rear, Kevin Carlin, Stephen Yu, Maritza Solorio, Bryan Lemon, Richard Austin, Holger Wesche, S. Jack Lin
Publikováno v:
Cancer Research. 83:2927-2927
Integrin-β6 (ITGB6) is a transmembrane protein that partners exclusively with the integrin-αV subunit to form the integrin-αVβ6 heterodimer. Due to its roles in tissue remodeling and cancer pathogenesis, therapeutic targeting of integrin-αVβ6 h
Autor:
Sony S. Rocha, Regina Lin, Maria R. Dayao, Raphaela Rose Banzon, Subramanian Thothathri, Kevin J. Wright, Wade Aaron, Yinghua Xiao, Nick Bergo, Linh To, Mabel Bush, Manasi Barath, Timothy Yu, Willis Kwong, Hubert Situ, Eric Bragg, Jessica O'Rear, Kevin Carlin, Stephen Yu, Maritza Solorio, Bryan Lemon, Richard Austin, Holger Wesche, S. Jack Lin
Publikováno v:
Cancer Research. 83:2928-2928
Tumor-associated calcium signal transducer 2 (Trop2) is a cell surface glycoprotein that promotes cell renewal, proliferation and tumorigenesis. Trop2 is homogenously overexpressed in numerous solid tumor types, including breast, head and neck, prost
Autor:
Kathryn Strobel Kwant, Sony S. Rocha, Timothy Yu, Katrina Stephenson, Raphaela Rose Banzon, Sydney Vollhardt, Golzar Hemmati, Evan Callihan, Wade H. Aaron, Subramanian Thothathri, Jessica O'Rear, Eric Bragg, Willis Kwong, Hubert Situ, Avneel Hundal, Stephen Yu, Taggra Jackson, Kevin Carlin, Yinghua Xiao, Maria Rosalyn Dayao, Linh To, Nick Bergo, Kevin Wright, Richard Austin, Holger Wesche, Bryan Lemon, S. Jack Lin
Publikováno v:
Cancer Research. 82:2861-2861
CD3-targeted T cell engagers are potent anti-tumor therapies, but their development often requires management of cytokine release syndrome (CRS). One strategy to reduce CRS is subcutaneous dosing, which is hypothesized to mitigate CRS by reducing the
Autor:
Hong I. Wan, Emma Sangalang, Tracy C. Kuo, Ons Harrabi, Laura Doyle, Janet Sim, Jaume Pons, Bora Han, Amy Y. Chen, Sangeetha Bollini, Sony S. Rocha, Steven E. Kauder
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201832 (2018)
PLoS ONE
PLoS ONE
CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune function