Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Sony Malhotra"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, the authors present Protein Interface-score (PI-score), a machine learning-based metric that has been trained on protein–protein interfaces’ features from high-resolution crystal structures. They use the PI-score to evaluate the protein–p
Externí odkaz:
https://doaj.org/article/acd3b58ac1e54f71ae0b83863127e269
Autor:
Sundeep Chaitanya Vedithi, Carlos H.M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L. Blundell, Sony Malhotra
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 271-286 (2020)
Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional cons
Externí odkaz:
https://doaj.org/article/8ccf97acfc614fb2aff96eaf6bc513fb
Autor:
Sundeep Chaitanya Vedithi, Sony Malhotra, Marcin J. Skwark, Asma Munir, Marta Acebrón-García-De-Eulate, Vaishali P Waman, Ali Alsulami, David B Ascher, Tom L Blundell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3692-3704 (2020)
Computational Saturation Mutagenesis is an in-silico approach that employs systematic mutagenesis of each amino acid residue in the protein to all other amino acid types, and predicts changes in thermodynamic stability and affinity to the other subun
Externí odkaz:
https://doaj.org/article/90bb350abd2e45eba96ca757d0601666
Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery
Autor:
Vaishali P. Waman, Sundeep Chaitanya Vedithi, Sherine E. Thomas, Bridget P. Bannerman, Asma Munir, Marcin J. Skwark, Sony Malhotra, Tom L. Blundell
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 109-118 (2019)
ABSTRACTOf the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium tuberculosis (causati
Externí odkaz:
https://doaj.org/article/9116d916e1344fa5bd606e3ae084c714
Autor:
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L. Blundell
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties, respectively, and control the
Externí odkaz:
https://doaj.org/article/5f2a40107c4f4a3294d397b9bf796386
Autor:
Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L. Blundell, Nuria E. Campillo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1034-1047 (2018)
Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has
Externí odkaz:
https://doaj.org/article/031329b95fd744a790fa10f49f5f386c
Autor:
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219935 (2019)
Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of p
Externí odkaz:
https://doaj.org/article/d89445722cc9499bba8dd7efcfff8dd5
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005883 (2017)
Mycobacteriaceae comprises pathogenic species such as Mycobacterium tuberculosis, M. leprae and M. abscessus, as well as non-pathogenic species, for example, M. smegmatis and M. thermoresistibile. Genome comparison and annotation studies provide insi
Externí odkaz:
https://doaj.org/article/adaeed619e7d485fa35eb02e671ed580
Autor:
Sony Malhotra, R. Sowdhamini
Publikováno v:
Bioinformatics and Biology Insights, Vol 2014, Iss 8, Pp 193-198 (2014)
Externí odkaz:
https://doaj.org/article/1c8d5810a92247c3870e4b3e89bae7fd
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e80255 (2014)
Interactions at the molecular level in the cellular environment play a very crucial role in maintaining the physiological functioning of the cell. These molecular interactions exist at varied levels viz. protein-protein interactions, protein-nucleic
Externí odkaz:
https://doaj.org/article/1d044964d89a4eccbe3c918d6a2b1c65