Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sonu Sahadevan"'
Autor:
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterlé, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina M. Hembach, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Stefano Antonucci, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Francesco Roselli, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression.
Externí odkaz:
https://doaj.org/article/81d53965ba1c4f5cbe4fa11bc13113fd
Autor:
Sonu Sahadevan, Katharina M. Hembach, Elena Tantardini, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Salim Megat, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.
Externí odkaz:
https://doaj.org/article/e9c043534e61495b8e1dfb249245ca1e
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2428
Cross-linking immunoprecipitation and high-throughput sequencing (CLIP-seq) allows the identification of RNA targets bound by a specific RNA-binding protein (RBP) in in vivo and ex vivo experimental models with high specificity. Due to the little RNA
Autor:
Pierre De Rossi, Marian Hruska-Plochan, Magdalini Polymenidou, Mark D. Robinson, Elena Tantardini, Luc Dupuis, Salim Megat, Julien Weber, Katharina M. Hembach, Petra Schwarz, Sonu Sahadevan, Manuela Pérez-Berlanga
Publikováno v:
Nature Communications
Nature Communications, 2021, 12 (1), pp.3027. ⟨10.1038/s41467-021-23188-8⟩
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3027. ⟨10.1038/s41467-021-23188-8⟩
Nature Communications, 2021, 12 (1), pp.3027. ⟨10.1038/s41467-021-23188-8⟩
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3027. ⟨10.1038/s41467-021-23188-8⟩
Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs, but its role at the synapse is poorly understood. Using super-resoluti
Autor:
Katharina M. Hembach, Elena Tantardini, Sonu Sahadevan, Mark D. Robinson, Marian Hruska-Plochan, Petra Schwarz, Julien Weber, Manuela Pérez-Berlanga, Luc Dupuis, Magdalini Polymenidou, P. de Rossi
FUS is a primarily nuclear RNA-binding protein with important roles in RNA processing and transport. FUS mutations disrupting its nuclear localization characterize a subset of amyotrophic lateral sclerosis (ALS-FUS) patients, through an unidentified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0b2073a3afa95a2ed4c1f16cc987bc
https://doi.org/10.1101/2020.06.10.136010
https://doi.org/10.1101/2020.06.10.136010
Autor:
Dorothee Dormann, Stefan Reber, Luc Dupuis, Helena Ederle, Marian Hruska-Plochan, Eva-Maria Hock, Marc-David Ruepp, Florent Laferrière, Zuzanna Maniecka, Lucas Pelkmans, M K Sonu Sahadevan, Tammaryn Lashley, Lauren M. Gittings, Magdalini Polymenidou
Publikováno v:
Cell Reports
Cell Reports, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Cell Reports, Elsevier Inc, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Hock, E-M, Maniecka, Z, Hruska-Plochan, M, Reber, S, Laferrière, F, Sahadevan M K, S, Ederle, H, Gittings, L, Pelkmans, L, Dupuis, L, Lashley, T, Ruepp, M-D, Dormann, D & Polymenidou, M 2018, ' Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function ', Cell Reports, vol. 24, no. 4, pp. 987-1000.e7 . https://doi.org/10.1016/j.celrep.2018.06.094
Cell Reports, 24 (4)
Cell Reports, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Cell Reports, Elsevier Inc, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Hock, E-M, Maniecka, Z, Hruska-Plochan, M, Reber, S, Laferrière, F, Sahadevan M K, S, Ederle, H, Gittings, L, Pelkmans, L, Dupuis, L, Lashley, T, Ruepp, M-D, Dormann, D & Polymenidou, M 2018, ' Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function ', Cell Reports, vol. 24, no. 4, pp. 987-1000.e7 . https://doi.org/10.1016/j.celrep.2018.06.094
Cell Reports, 24 (4)
The primarily nuclear RNA-binding protein FUS (fused in sarcoma) forms pathological cytoplasmic inclusions in a subset of early-onset amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. In response to cellular stress, FUS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26cd76ee2b60a0880af6400794f15f6
https://doi.org/10.1016/j.celrep.2018.06.094
https://doi.org/10.1016/j.celrep.2018.06.094
Autor:
Aristotelis Antonopoulos, Subramanian Ramaswamy, Anne Dell, Stuart M. Haslam, Ponnusamy Babu, Sonu Sahadevan
Publikováno v:
ACS chemical biology. 9(1)
Cell-cell communications, cell-matrix interactions, and cell migrations play a major role in regeneration. However, little is known about the molecular players involved in these critical events, especially cell surface molecules. Here, we demonstrate