Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Sonsoles Velázquez"'
Autor:
Noelia Hernández-Ortiz, Pedro A. Sánchez-Murcia, Celia Gil-Campillo, Mirian Domenech, Daniel Lucena-Agell, Rafael Hortigüela, Sonsoles Velázquez, María José Camarasa, Noemí Bustamante, Sonia de Castro, Margarita Menéndez
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cationic ultrashort lipopeptides (USLPs) are promising antimicrobial candidates to combat multidrug-resistant bacteria. Using DICAMs, a newly synthesized family of tripeptides with net charges from −2 to +1 and a fatty amine conjugated to the C-ter
Externí odkaz:
https://doaj.org/article/a70e508a6e444b3684cb75e82eb032ee
Autor:
Martín Alcorlo, Mohammed R Abdullah, Leif Steil, Francisco Sotomayor, Laura López-de Oro, Sonia de Castro, Sonsoles Velázquez, Thomas P Kohler, Elisabet Jiménez, Ana Medina, Isabel Usón, Lance E Keller, Jessica L Bradshaw, Larry S McDaniel, María-José Camarasa, Uwe Völker, Sven Hammerschmidt, Juan A Hermoso
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1011883 (2024)
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of the pathobiont Streptococcus pneumoniae (pneumococcus) is
Externí odkaz:
https://doaj.org/article/b962a379033346788836c4582103dd80
Autor:
Sara B Hernández, Sónia Castanheira, M Graciela Pucciarelli, Juan J Cestero, Gadea Rico-Pérez, Alberto Paradela, Juan A Ayala, Sonsoles Velázquez, Ana San-Félix, Felipe Cava, Francisco García-Del Portillo
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010241 (2022)
Salmonella enterica causes intracellular infections that can be limited to the intestine or spread to deeper tissues. In most cases, intracellular bacteria show moderate growth. How these bacteria face host defenses that recognize peptidoglycan, is p
Externí odkaz:
https://doaj.org/article/7dd6a885505c44edb5456e0931c6a09f
Autor:
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1021 (2022)
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–ac
Externí odkaz:
https://doaj.org/article/d301b0071e384bba936c2d8ac80db4e5
Autor:
Alejandro Revuelto, Isabel López-Martín, Héctor de Lucio, Juan Carlos García-Soriano, Nicola Zanda, Sonia de Castro, Federico Gago, Antonio Jiménez-Ruiz, Sonsoles Velázquez, María-José Camarasa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 689 (2021)
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Externí odkaz:
https://doaj.org/article/ae16e1932b9142b884536d0bb5ad011f
Autor:
Héctor de Lucio, Alejandro Revuelto, Alejandra A. Carriles, Sonia de Castro, Sonia García-González, Juan Carlos García-Soriano, Mercedes Alcón-Calderón, Pedro A. Sánchez-Murcia, Juan A. Hermoso, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez
Publikováno v:
European journal of medicinal chemistry. 244
N-methylation of the triazole moiety present in our recently described triazole-phenyl-thiazole dimerization disruptors of Leishmania infantum trypanothione disulfide reductase (LiTryR) led to a new class of potent in- hibitors that target different
Autor:
Sara B. Hernández, Sónia Castanheira, M. Graciela Pucciarelli, Juan J. Cestero, Gadea Rico-Pérez, Alberto Paradela, Juan A. Ayala, Sonsoles Velázquez, Ana San-Félix, Felipe Cava, Francisco García-del Portillo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010241 (2022)
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010241 (2022)
Salmonella enterica causes intracellular infections that can be limited to the intestine or spread to deeper tissues. In most cases, intracellular bacteria show moderate growth. How these bacteria face host defenses that recognize peptidoglycan, is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926a783c26097c9cc690393d3ea8bcc6
https://hdl.handle.net/10486/700965
https://hdl.handle.net/10486/700965
Autor:
Mercedes Alcón-Calderón, Héctor de Lucio, Juan Carlos García-Soriano, Alejandro Revuelto, Sonia de Castro, Celia López-Gutiérrez, Ana San-Félix, Ernesto Quesada, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypa- nothione disulfide reductase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb3a98ac776176e5a689cd192aca99
http://hdl.handle.net/10261/279364
http://hdl.handle.net/10261/279364
Autor:
Nicola Zanda, Sonia de Castro, Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Federico Gago, Alejandro Revuelto, María-José Camarasa, Isabel López-Martín, Sonsoles Velázquez
Publikováno v:
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Autor:
Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Sonsoles Velázquez, Federico Gago, Alejandro Revuelto, María-José Camarasa, Pedro A. Sánchez-Murcia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Medicinal Chemistry
instname
Journal of Medicinal Chemistry
Inhibition of Leishmania infantum trypanothione disulfide reductase (LiTryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of concept was firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca5784a0763c514320a850ea5fdb2fc
http://hdl.handle.net/10261/252819
http://hdl.handle.net/10261/252819