Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Sonsoles Martín Santamaría"'
Autor:
Flaviana Di Lorenzo, Molly D. Pither, Michela Martufi, Ilaria Scarinci, Joan Guzmán-Caldentey, Ewelina Łakomiec, Wojciech Jachymek, Sven C. M. Bruijns, Sonsoles Martín Santamaría, Julia-Stephanie Frick, Yvette van Kooyk, Fabrizio Chiodo, Alba Silipo, Maria Lina Bernardini, Antonio Molinaro
Publikováno v:
ACS Central Science, Vol 6, Iss 9, Pp 1602-1616 (2020)
Externí odkaz:
https://doaj.org/article/332343cee52a48dca92544a6b14e0bf2
Autor:
Lucía Pérez-Regidor, Joan Guzmán-Caldentey, Nils Oberhauser, Carmen Punzón, Balázs Balogh, José R. Pedro, Eva Falomir, Alessandra Nurisso, Péter Mátyus, J. Carlos Menéndez, Belén de Andrés, Manuel Fresno, Sonsoles Martín-Santamaría
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2326 (2022)
The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a “computer-aided drug repurposing” approach was applied to the discovery of novel TLR4 modulators w
Externí odkaz:
https://doaj.org/article/0f1178007a05470795f7fc9e89be0e3d
Autor:
Víctor Collado-Díaz, Maria Ángeles Martinez-Cuesta, Maria Amparo Blanch-Ruiz, Ainhoa Sánchez-López, Patricia García-Martínez, José E Peris, Iris Usach, Maria Dolores Ivorra, Alessandra Lacetera, Sonsoles Martín-Santamaría, Juan V. Esplugues, Angeles Alvarez
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the inte
Externí odkaz:
https://doaj.org/article/b54c2fc280984118ad7cf4027208431e
Autor:
Andreia Mónico, Joan Guzmán-Caldentey, María A. Pajares, Sonsoles Martín-Santamaría, Dolores Pérez-Sala
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1039 (2021)
The intermediate filament protein vimentin is involved in essential cellular processes, including cell division and stress responses, as well as in the pathophysiology of cancer, pathogen infection, and autoimmunity. The vimentin network undergoes ma
Externí odkaz:
https://doaj.org/article/972c9988f8484c658b2df4ed66d87b58
Autor:
Alessio Romerio, Nicole Gotri, Ana Rita Franco, Valentina Artusa, Mohammed Monsoor Shaik, Samuel T. Pasco, Unai Atxabal, Alejandra Matamoros-Recio, Marina Mínguez-Toral, Juan Diego Zalamea, Antonio Franconetti, Nicola G. A. Abrescia, Jesus Jimenez-Barbero, Juan Anguita, Sonsoles Martín-Santamaría, Francesco Peri
20 p.-15 fig.-1 graph. abst.
We disclose here a panel of small-molecule TLR4 agonists (the FP20 series) whose structure is derived from previously developed TLR4 ligands (FP18 series). The new molecules have increased chemical stability and a sh
We disclose here a panel of small-molecule TLR4 agonists (the FP20 series) whose structure is derived from previously developed TLR4 ligands (FP18 series). The new molecules have increased chemical stability and a sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e7bcb0dd3c08fb28690d77fd3554e9
http://hdl.handle.net/10261/289399
http://hdl.handle.net/10261/289399
Autor:
Sonya Entova, Jean-Marc Billod, Jean-Marie Swiecicki, Sonsoles Martín-Santamaría, Barbara Imperiali
Publikováno v:
eLife, Vol 7 (2018)
Monotopic membrane proteins integrate into the lipid bilayer via reentrant hydrophobic domains that enter and exit on a single face of the membrane. Whereas many membrane-spanning proteins have been structurally characterized and transmembrane topolo
Externí odkaz:
https://doaj.org/article/2a48de7353c14aadbeba8cf950a0a544
Autor:
Juan Felipe Franco-Gonzalez, Lucia Perez-Regidor, Alejandra Matamoros-Recio, Sonsoles Martín-Santamaría, Joan Guzmán-Caldentey, Jean-Marc Billod
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry (Weinheim an Der Bergstrasse, Germany)
instname
Chemistry (Weinheim an Der Bergstrasse, Germany)
21 p.-14 fig. In Memoriam Prof. Kilian Muñiz (R.I.P.). Excellent person, great heart.
The innate immunity TLR4/MD-2 system is a membrane receptor of paramount importance as therapeutic target. Its assembly, upon binding of Gram-negative bacteri
The innate immunity TLR4/MD-2 system is a membrane receptor of paramount importance as therapeutic target. Its assembly, upon binding of Gram-negative bacteri
Autor:
Nicole Gotri, Fabio A. Facchini, Alberto Minotti, Guanbo Wang, Grisha Pirianov, Marco De Andrea, Miguel A. Valvano, Alessio Romerio, Francesco Peri, Rebecca J. Ingram, Alejandra Matamoros-Recio, Charys Palmer, Sonsoles Martín-Santamaría, Andrea Luraghi, Andrea Iannucci
Publikováno v:
Facchini, F A, Minotti, A, Luraghi, A, Romerio, A, Gotri, N, Matamoros-Recio, A, Iannucci, A, Palmer, C, Wang, G, Ingram, R, Martin-Santamaria, S, Pirianov, G, De Andrea, M, Valvano, M A & Peri, F 2021, ' Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity ', Journal of Medicinal Chemistry . https://doi.org/10.1021/acs.jmedchem.1c00896
Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
12 p.-7 fig.-1 schem.-1 graph. abst.
Modern adjuvants for vaccine formulations are immunostimulating agents whose action is based on the activation of pattern recognition receptors (PRRs) by well-defined ligands to boost innate and adaptive immu
Modern adjuvants for vaccine formulations are immunostimulating agents whose action is based on the activation of pattern recognition receptors (PRRs) by well-defined ligands to boost innate and adaptive immu
Autor:
Paula Gratal, Aránzazu Mediero, Ana Lamuedra, Alejandra Matamoros‐Recio, Carmen Herencia, Gabriel Herrero‐Beaumont, Sonsoles Martín‐Santamaría, Raquel Largo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
49 p.-9 fig.-1 tab.-1 graph. abst.
Background and purpose: The pathogenesis of osteoarthritis (OA) implicates a low-grade inflammation associated to the activation of the innate immune system. Toll like receptor (TLR) stimulation triggers the re
Background and purpose: The pathogenesis of osteoarthritis (OA) implicates a low-grade inflammation associated to the activation of the innate immune system. Toll like receptor (TLR) stimulation triggers the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e604d0f652c12b8242d218f519eed41
http://hdl.handle.net/10261/273867
http://hdl.handle.net/10261/273867
Autor:
Sonsoles Martín-Santamaría, María A. Pajares, Dolores Pérez-Sala, Joan Guzmán-Caldentey, Andreia Mónico
Publikováno v:
Antioxidants
Volume 10
Issue 7
Digital.CSIC. Repositorio Institucional del CSIC
instname
Antioxidants, Vol 10, Iss 1039, p 1039 (2021)
Volume 10
Issue 7
Digital.CSIC. Repositorio Institucional del CSIC
instname
Antioxidants, Vol 10, Iss 1039, p 1039 (2021)
23 p.-7 fig.
The intermediate filament protein vimentin is involved in essential cellular processes, including cell division and stress responses, as well as in the pathophysiology of cancer, pathogen infection, and autoimmunity. The vimentin ne
The intermediate filament protein vimentin is involved in essential cellular processes, including cell division and stress responses, as well as in the pathophysiology of cancer, pathogen infection, and autoimmunity. The vimentin ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad2c792fd0abf067cc50bfb64cee2c1
http://hdl.handle.net/10261/259230
http://hdl.handle.net/10261/259230