Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Sonoko Narisawa"'
Autor:
Flavia Amadeu de Oliveira, Fatma F. Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan
Publikováno v:
JBMR Plus, Vol 7, Iss 1, Pp n/a-n/a (2023)
ABSTRACT Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐thr
Externí odkaz:
https://doaj.org/article/513ba8e0b1914747a10e53df0d3557f7
Autor:
Akihiro Hasegawa, Aki Nakamura-Takahashi, Masataka Kasahara, Nana Saso, Sonoko Narisawa, José Luis Millán, Osamu Samura, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa
Publikováno v:
Regenerative Therapy, Vol 18, Iss , Pp 168-175 (2021)
Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful tr
Externí odkaz:
https://doaj.org/article/c9dde3dbb11342f7a7366c05cf01dec6
Autor:
Tae Matsumoto, Koichi Miyake, Noriko Miyake, Osamu Iijima, Kumi Adachi, Sonoko Narisawa, José Luis Millán, Hideo Orimo, Takashi Shimada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 330-337 (2021)
Hypophosphatasia (HPP) is an inherited skeletal disease characterized by defective bone and tooth mineralization due to a deficiency in tissue-nonspecific alkaline phosphatase (TNALP). Patients with the severe infantile form of HPP may appear normal
Externí odkaz:
https://doaj.org/article/1ff49d3faba441c2809be7d1ef379b22
Autor:
Álvaro Sebastián-Serrano, Jesús Merchán-Rubira, Caterina Di Lauro, Carolina Bianchi, Lucía Soria-Tobar, Sonoko Narisawa, José L. Millán, Jesús Ávila, Félix Hernández, Miguel Díaz-Hernández
Publikováno v:
Neurobiology of Disease, Vol 165, Iss , Pp 105632- (2022)
Tauopathies are a family of neurodegenerative diseases characterized by the presence of abnormally hyperphosphorylated Tau protein. Several studies have proposed that increased extracellular Tau (eTau) leads to the spread of cerebral tauopathy. Howev
Externí odkaz:
https://doaj.org/article/3b8bcb6c828f4b35be0d7252171b0ea4
Autor:
Fatma F. Mohamed, Michael B. Chavez, Flavia Amadeu de Oliveira, Sonoko Narisawa, Colin Farquharson, José Luis Millán, Brian L. Foster
Publikováno v:
Frontiers in Dental Medicine, Vol 3 (2022)
Mineralization of the skeleton occurs by several physicochemical and biochemical processes and mechanisms that facilitate the deposition of hydroxyapatite (HA) in specific areas of the extracellular matrix (ECM). Two key phosphatases, phosphatase, or
Externí odkaz:
https://doaj.org/article/84196a09825f413fb3b91696b14a57c3
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100601- (2020)
Externí odkaz:
https://doaj.org/article/24bfc6a67bcc44a29b8398856391b596
Autor:
Shohei Sasaki, Hiroko Segawa, Ai Hanazaki, Ruri Kirino, Toru Fujii, Kayo Ikuta, Miwa Noguchi, Sumire Sasaki, Megumi Koike, Kazuya Tanifuji, Yuji Shiozaki, Ichiro Kaneko, Sawako Tatsumi, Takaaki Shimohata, Yoshichika Kawai, Sonoko Narisawa, José Luis Millán, Ken-ichi Miyamoto
Publikováno v:
Kidney & Blood Pressure Research, Vol 43, Iss 5, Pp 1409-1424 (2018)
Background/Aims: Hyperphosphatemia is a serious complication of late-stage chronic kidney disease (CKD). Intestinal inorganic phosphate (Pi) handling plays an important role in Pi homeostasis in CKD. We investigated whether intestinal alkaline phosph
Externí odkaz:
https://doaj.org/article/36c57e898e644c9e9d8a52246f8a75e4
Autor:
Aki Nakamura-Takahashi, Koichi Miyake, Atsushi Watanabe, Yukihiko Hirai, Osamu Iijima, Noriko Miyake, Kumi Adachi, Yuko Nitahara-Kasahara, Hideaki Kinoshita, Taku Noguchi, Shinichi Abe, Sonoko Narisawa, Jose Luis Millán, Takashi Shimada, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Hypophosphatasia (HPP) is an inherited disease caused by genetic mutations in the gene encoding tissue-nonspecific alkaline phosphatase (TNALP). This results in defects in bone and tooth mineralization. We recently demonstrated that TNALP-deficient (
Externí odkaz:
https://doaj.org/article/b854796ff45a455191ade5d1a6c16743
Autor:
Bo Yang, Mingliang Qu, Rengang Wang, Jon E Chatterton, Xiao-Bo Liu, Bing Zhu, Sonoko Narisawa, Jose Luis Millan, Nobuki Nakanishi, Kathryn Swoboda, Stuart A Lipton, Dongxian Zhang
Publikováno v:
eLife, Vol 4 (2015)
Hitherto, membralin has been a protein of unknown function. Here, we show that membralin mutant mice manifest a severe and early-onset motor neuron disease in an autosomal recessive manner, dying by postnatal day 5–6. Selective death of lower motor
Externí odkaz:
https://doaj.org/article/6372ba534f6042f3a37c0d0883d048b4
Autor:
Marc F Hoylaerts, Soetkin Van Kerckhoven, Tina Kiffer-Moreira, Campbell Sheen, Sonoko Narisawa, José Luis Millán
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119874 (2015)
The conserved active site of alkaline phosphatases (AP) contains catalytically important Zn2+ (M1 and M2) and Mg2+-sites (M3) and a fourth peripheral Ca2+ site (M4) of unknown significance. We have studied Ca2+ binding to M1-4 of tissue-nonspecific A
Externí odkaz:
https://doaj.org/article/d7deb1e7f309434dbcd8a91b1f21cb14