Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sonoko Kanai"'
Publikováno v:
Molecular Pharmaceutics. 12:411-419
Oligomerization of lipidated peptides is of general scientific interest and is important in biomedical and pharmaceutical applications. We investigated the solution properties of a lipidated peptide, Liraglutide, which is one of the glucagon-like pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748782ef2246446c6ca4eca26b9c381f
https://doi.org/10.1021/mp500519s
https://doi.org/10.1021/mp500519s
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 33(31)
Oligomeric peptides exist widely in living organisms and play a role in a broad range of biological functions. We report the first observation of liquid–liquid phase separation (LLPS) in peptide solutions, in particular, solutions of peptides consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410b8e7b3cc9396cd39aa8594dba5270
https://pubmed.ncbi.nlm.nih.gov/28689408
https://pubmed.ncbi.nlm.nih.gov/28689408
Autor:
Thomas M. Scherer, James Andya, Yatin R. Gokarn, Barthélemy Demeule, Sonoko Kanai, Sandeep Yadav, Steven J. Shire, Jun Liu
Publikováno v:
Biophysical Reviews. 5:121-136
Early development of protein biotherapeutics using recombinant DNA technology involved progress in the areas of cloning, screening, expression and recovery/purification. As the biotechnology industry matured, resulting in marketed products, a greater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1083b4459742be33a09046cf269ec649
https://doi.org/10.1007/s12551-013-0109-z
https://doi.org/10.1007/s12551-013-0109-z
Publikováno v:
Pharmaceutical Research. 26:2478-2485
This paper shows the first ever assembly of monoclonal antibody using multivalent carboxylate ions into highly ordered structures that feature viscoelastic properties reminiscent of other filamentous proteins.A monoclonal antibody was assembled into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c03f73cf3f84476498ac5f5d2c6111
https://doi.org/10.1007/s11095-009-9963-6
https://doi.org/10.1007/s11095-009-9963-6
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4219-4227
Reversible self-association of a monoclonal antibody (MAb) in a high concentration formulation results in a solution with a high viscosity. The nature of the self-association of full-length as well as antibody fragments has been studied by rheometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78c0c9b78912f2d0eb3e7e0ad6a8f5e
https://doi.org/10.1002/jps.21322
https://doi.org/10.1002/jps.21322
Autor:
Aleksey Lomakin, Rainer Alex, George B. Benedek, Sara Belli, Massimiliano Donzelli, Sonoko Kanai, Ying Wang
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 241
Hybrid incretin peptides are a new generation of drugs for the treatment of diabetes and obesity. Despite their biological potency, the effectiveness of these peptides as drugs is limited by their short circulation time in blood (typically within min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3af95d1f01a9883fb42f2e541b587c
https://pubmed.ncbi.nlm.nih.gov/27578099
https://pubmed.ncbi.nlm.nih.gov/27578099
Autor:
Mary K. Cowman, Sonoko Kanai, Ansil Dyal, Min Li, Chiara Spagnoli, Dina S. Kudasheva, Endre A. Balazs
Publikováno v:
Biophysical Journal. 88:590-602
The conformation of the polysaccharide hyaluronan (HA) has been investigated by tapping mode atomic force microscopy in air. HA deposited on a prehydrated mica surface favored an extended conformation, attributed to molecular combing and inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa6e39c2f8d64f963269dbf6aa9a70c
https://doi.org/10.1529/biophysj.104.049361
https://doi.org/10.1529/biophysj.104.049361
Autor:
Devendra S. Kalonia, Jun Liu, Steven J. Shire, Henry B. Lowman, Samantha Lien, Sonoko Kanai, Alavattam Sreedhara, Sandeep Yadav
Publikováno v:
Pharmaceutical research. 28(7)
To investigate the underlying cause for the observed differences in self-associating and viscoelastic behavior between two monoclonal antibodies, MAb1, and MAb2. Several mutants were designed by swapping charged residues in MAb1 with those present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f694efbc594a48ecc949bf441f4853d
https://pubmed.ncbi.nlm.nih.gov/21626060
https://pubmed.ncbi.nlm.nih.gov/21626060
Publikováno v:
The journal of physical chemistry. B. 113(17)
Multiple molecular driving forces mediate protein stability, association, and recognition in concentrated solutions. Here we investigate the interactions that modulate the nonideal solution behavior of two immunoglobulins (IgG1s) in highly concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7576eca4be5069dbff5c66e5cc0767fe
https://pubmed.ncbi.nlm.nih.gov/19341314
https://pubmed.ncbi.nlm.nih.gov/19341314
Autor:
Murugappan Muthukumar, Sonoko Kanai
Publikováno v:
The Journal of chemical physics. 127(24)
The kinetics of phase separation of aqueous solutions of sodium-poly(styrene sulfonate) (NaPSS) containing barium chloride (BaCl(2)) is studied by static and dynamic light scattering. We report a novel mechanism of phase separation, where an enrichme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51843443711df5476e1dfe29a23123ec
https://pubmed.ncbi.nlm.nih.gov/18163707
https://pubmed.ncbi.nlm.nih.gov/18163707