Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning.

Autor: Kawai M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. fukuda26@kuhp.kyoto-u.ac.jp., Otomo R; Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto, Japan., Obata S; Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto, Japan., Minaga K; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan., Asada M; Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan., Umemura A; Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Uenoyama Y; Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan., Hieda N; Department of Gastroenterology, Otsu Red Cross Hospital, Shiga, Japan., Morita T; Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan., Minami R; Department of Gastroenterology, Tenri Hospital, Nara, Japan., Marui S; Department of Gastroenterology and Hepatology, Shiga General Hospital, Shiga, Japan., Yamauchi Y; Department of Gastroenterology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan., Nakai Y; Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan., Takada Y; Department of Gastroenterology and Hepatology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan., Ikuta K; Division of Gastroenterology, Shinko Hospital, Kobe, Japan., Yoshioka T; Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Takatsuki, Japan., Mizukoshi K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Iwane K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Yamakawa G; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Namikawa M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Sono M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Nagao M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Nakanishi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan., Hirai M; Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto, Japan., Kanda N; Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Takatsuki, Japan., Shio S; Division of Gastroenterology, Shinko Hospital, Kobe, Japan., Itani T; Department of Gastroenterology and Hepatology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan., Fujii S; Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan., Kimura T; Department of Gastroenterology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan., Matsumura K; Department of Gastroenterology and Hepatology, Shiga General Hospital, Shiga, Japan., Ohana M; Department of Gastroenterology, Tenri Hospital, Nara, Japan., Yazumi S; Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan., Kawanami C; Department of Gastroenterology, Otsu Red Cross Hospital, Shiga, Japan., Yamashita Y; Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan., Marusawa H; Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan., Watanabe T; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan., Ito Y; Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kudo M; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan., Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.

Publikováno v: British journal of cancer [Br J Cancer] 2024 Oct; Vol. 131 (7), pp. 1158-1168. Date of Electronic Publication: 2024 Aug 28.

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.

Autor: Omatsu M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakanishi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. yuki@kuhp.kyoto-u.ac.jp., Iwane K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Aoyama N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Duran A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Muta Y; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA.; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Martinez-Ordoñez A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Han Q; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Agatsuma N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mizukoshi K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kawai M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yamakawa G; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Namikawa M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hamada K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Fukunaga Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Cancer Research Unit, Sumitomo Pharma Co., Ltd, Osaka, Japan., Utsumi T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sono M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Masuda T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hata A; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Araki O; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nagao M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yoshikawa T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ogawa S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hiramatsu Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tsuda M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kogame T; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kasashima H; Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan., Kakiuchi N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan., Nakagawa MM; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Kawada K; Department of Gastrointestinal Surgery, Kyoto University, Graduate School of Medicine, Kyoto, Japan., Yashiro M; Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan., Maeda K; Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan., Saito Y; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan., Matozaki T; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Division of Biosignal Regulation, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kabashima K; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Obama K; Department of Gastrointestinal Surgery, Kyoto University, Graduate School of Medicine, Kyoto, Japan., Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Sheibani N; Department of Ophthalmology and Visual Sciences, University of Wisconsin-, Madison, Wisconsin, USA., Diaz-Meco MT; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Moscat J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 25; Vol. 14 (1), pp. 5534. Date of Electronic Publication: 2023 Sep 25.

Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.

Autor: Namikawa M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mizukoshi K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Iwane K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kawai M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yamakawa G; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Omatsu M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sono M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Masuda T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Araki O; Kyoto-Katsura Hospital, Kyoto, Japan., Nagao M; Tenri Hospital, Nara, Japan., Yoshikawa T; Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan., Ogawa S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hiramatsu Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Muta Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tsuda M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakanishi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tsuruyama T; Department of Drug Discovery Medicine, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan., Taura K; Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan.; Division of Hepatobiliary Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hatano E; Division of Hepatobiliary Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Publikováno v: The Journal of pathology [J Pathol] 2023 Aug; Vol. 260 (4), pp. 478-492. Date of Electronic Publication: 2023 Jun 13.

JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression.

Autor: Yoshikawa T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Omatsu M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Namikawa M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sono M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Fukunaga Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Drug Discovery Medicine, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan., Masuda T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Araki O; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nagao M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ogawa S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Masuo K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Laboratory for Malignancy Control Research (DSK Project), Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan., Goto N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hiramatsu Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Muta Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tsuda M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakanishi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kawada K; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Takaishi S; Laboratory for Malignancy Control Research (DSK Project), Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan., Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Publikováno v: Cancer science [Cancer Sci] 2022 Oct; Vol. 113 (10), pp. 3417-3427. Date of Electronic Publication: 2022 Aug 17.

Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice.

Autor: Nagao M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Omatsu M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Namikawa M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Sono M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Fukunaga Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.; Department of Drug Discovery Medicine, Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Masuda T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Araki O; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Yoshikawa T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Ogawa S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Masuo K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Goto N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Hiramatsu Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Muta Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Tsuda M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Nakanishi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Taketo MM; Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Kita-ku, Osaka, Japan.; iACT, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan., Ferrer J; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain.; Genetics and Genomics Section, Department of Metabolism, Digestion and Reproduction, National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, United Kingdom., Tsuruyama T; Department of Drug Discovery Medicine, Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Nakanuma Y; Department of Diagnostic Pathology, Fukui Prefecture Saiseikai Hospital, Fukui, Japan., Taura K; Division of Hepatobiliary Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Uemoto S; Division of Hepatobiliary Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan., Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.

Publikováno v: Cancer research [Cancer Res] 2022 May 03; Vol. 82 (9), pp. 1803-1817.