The nociceptin/orphanin FQ receptor system as a target to alleviate cancer‐induced bone pain in rats: Model validation and pharmacological evaluation

Autor: Thomas M. Tzschentke, Thomas Christoph, Johanna Korioth, Marta Diaz-delCastillo, Sonny Hermanus Johannes Sliepen, Kris Rutten, Anne-Marie Heegaard

Publikováno v: Sliepen, S H J, Korioth, J, Christoph, T, Tzschentke, T M, Diaz-delCastillo, M, Heegaard, A-M & Rutten, K 2021, ' The nociceptin/orphanin FQ receptor system as a target to alleviate cancer-induced bone pain in rats : Model validation and pharmacological evaluation ', British Journal of Pharmacology, vol. 178, no. 9, 14899, pp. 1995-2007 . https://doi.org/10.1111/bph.14899
British Journal of Pharmacology

Background and purpose Cancer-induced bone pain remains inadequately controlled, and current standard of care analgesics is accompanied by several side effects. Nociceptin/orphanin FQ peptide (NOP) receptor agonists have demonstrated broad analgesic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99e52db221f900aca1d6e1b7091a2be
https://doi.org/10.1111/bph.14899

Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat

Autor: Marta Diaz-delCastillo, Thomas Christoph, Rikke Brix Olsen, Kris Rutten, Anne-Marie Heegaard, Johanna Korioth, Sonny Hermanus Johannes Sliepen, Camilla Kristine Appel

Publikováno v: Sliepen, S H J, Diaz-Delcastillo, M, Korioth, J, Olsen, R B, Appel, C K, Christoph, T, Heegaard, A-M & Rutten, K 2019, ' Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat ', In Vivo, vol. 33, no. 4, pp. 1125-1132 . https://doi.org/10.21873/invivo.11582

BACKGROUND: Cancer-induced bone pain remains a serious public health concern, with a need for translational behavioural tests in order to assess nociception in preclinical models of this condition. Burrowing is an innate, ethologically relevant roden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a221de5888c8c6202163a5f08f59dd4
https://curis.ku.dk/portal/da/publications/cancerinduced-bone-pain-impairs-burrowing-behaviour-in-mouse-and-rat(bcba5366-02e1-47f4-a023-73c154bebd69).html