Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sonny Dike"'
Publikováno v:
The American Journal of Pathology. 179:850-859
Lipoprotein particles accumulate in Bruch's membrane before the development of basal deposits and drusen, two histopathologic lesions that define age-related macular degeneration (AMD). We therefore, sought to determine which molecules could particip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87657eee2c45b02996163e064d085524
https://doi.org/10.1016/j.ajpath.2011.04.010
https://doi.org/10.1016/j.ajpath.2011.04.010
Autor:
Deepa M. Deshpande, Douglas A. Kerr, Sonny Dike, Jeremy M. Shefner, Irina Shats, Chitra Krishnan, Tara Martinez, Jessica Carmen, Nicholas J. Maragakis, Yun Sook Kim, Ahmet Hoke, Jennifer Drummond, Jeffrey D. Rothstein, Lee L. Rubin
Publikováno v:
Annals of Neurology. 60:32-44
Objective: We explored the potential of embryonic stem cell–derived motor neurons to functionally replace those cells destroyed in paralyzed adult rats. Methods: We administered a phosphodiesterase type 4 inhibitor and dibutyryl cyclic adenosine mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305ff1256368ee4cb78e1b5fd4a69622
https://doi.org/10.1002/ana.20901
https://doi.org/10.1002/ana.20901
Viral-Induced Spinal Motor Neuron Death Is Non-Cell-Autonomous and Involves Glutamate Excitotoxicity
Autor:
David N. Irani, Douglas A. Kerr, Jessica Darman, Nicholas J. Maragakis, Jeffrey D. Rothstein, Chitra Krishnan, Stephanie Backovic, Sonny Dike
Publikováno v:
The Journal of Neuroscience. 24:7566-7575
Neuroadapted Sindbis virus (NSV) is a neurotropic virus capable of inducing the death of spinal motor neurons in mice and rats. In this study we investigated the mechanisms that underlie NSV-induced motor neuron death. We found that many degenerating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7a9bcb9fe08bd4811f161f3b556843
https://doi.org/10.1523/jneurosci.2002-04.2004
https://doi.org/10.1523/jneurosci.2002-04.2004
Autor:
Jeffrey D. Rothstein, John D. Gearhart, Michael J. Shamblott, Chitra Krishnan, Sonny Dike, Nicholas J. Maragakis, Douglas A. Kerr, Jerònia Lladó, Thomas O. Crawford, David N. Irani
Publikováno v:
The Journal of Neuroscience. 23:5131-5140
We have investigated the potential of human pluripotent cells to restore function in rats paralyzed with a virus-induced motor neuronopathy. Cells derived from embryonic germ cells, termed embryoid body-derived (EBD) cells, introduced into the CSF we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9148d79bb69989f62a9aa1f00ba32acb
https://doi.org/10.1523/jneurosci.23-12-05131.2003
https://doi.org/10.1523/jneurosci.23-12-05131.2003
Autor:
Douglas A. Kerr, Elizabeth A. Jonas, Craig B. Thompson, Chong Hyun Kim, J. Marie Hardwick, Ted M. Dawson, Diane E. Griffin, Tullia Lindsten, Toshiaki Mito, Richard L. Huganir, Yihru Fannjiang, Andrea L. Sappington, Leonard K. Kaczmarek, Shifa Zou, Sonny Dike, Thomas Larsen, Richard J. Traystman, Allen S. Mandir
Publikováno v:
Developmental Cell. 4:575-585
BAK is a pro-apoptotic BCL-2 family protein that localizes to mitochondria. Here we evaluate the function of BAK in several mouse models of neuronal injury including neuronotropic Sindbis virus infection, Parkinson's disease, ischemia/stroke, and sei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2387bc8e85895d237ed951c607ffb2e
https://doi.org/10.1016/s1534-5807(03)00091-1
https://doi.org/10.1016/s1534-5807(03)00091-1
n-Dodecyl-β-D-maltoside inhibits aggregation of human interferon-β-1b and reduces its immunogenicity
Publikováno v:
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 6(1)
The development of neutralizing antibodies to the protein drug interferon-β is a significant impediment to its use in the treatment of multiple sclerosis. Neutralizing antibodies to interferon-β arise from aggregation of the peptide during manufact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8730ccce844393be5986f8d194d9a3
https://pubmed.ncbi.nlm.nih.gov/20532646
https://pubmed.ncbi.nlm.nih.gov/20532646
Autor:
Melina Jones, Brian Rothstein, Cynthia A. DeBoy, Susumu Mori, Daniel S. Reich, Douglas A. Kerr, Peter A. Calabresi, Thien Nguyen, Irina Shats, Jiangyang Zhang, Sonny Dike, John T. Griffin, Robert H. Miller
Publikováno v:
Brain : a journal of neurology. 130(Pt 8)
Inflammation, demyelination, gliosis and axonal degeneration are pathological hallmarks of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis. Axonal damage is thought to contribute to irreversible damage and functional impairment,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d626acddfd28ab4fcc41368ad1530653
https://pubmed.ncbi.nlm.nih.gov/17557778
https://pubmed.ncbi.nlm.nih.gov/17557778
Autor:
Jessica Carmen, Sonny Dike, Peter A. Calabresi, Erick R. Scott, Douglas A. Kerr, Chitra Krishnan, Jennifer Drummond, Sanjay C. Keswani, Timothy H. Moran, Adam I. Kaplin, Tara Martinez, Carlos A. Pardo, Mikhail V. Pletnikov, Deepa M. Deshpande, Irina Shats
Transverse myelitis (TM) is an immune-mediated spinal cord disorder associated with inflammation, demyelination, and axonal damage. We investigated the soluble immune derangements present in TM patients and found that IL-6 levels were selectively and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55a67ed929d8195ec845d5b54659a4c
https://europepmc.org/articles/PMC1224298/
https://europepmc.org/articles/PMC1224298/
Autor:
Cynthia A. DeBoy, Jiangyang Zhang, Sonny Dike, Irina Shats, Melina Jones, Daniel S. Reich, Susumu Mori, Thien Nguyen, Brian Rothstein, Robert H. Miller, John T. Griffin, Douglas A. Kerr, Peter A. Calabresi
Publikováno v:
Brain: A Journal of Neurology; Aug2007, Vol. 130 Issue 8, p2199-2199, 1p