Výsledky vyhledávání - "Sonny A Khin"

Akademický článek

Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues.

Autor: Thomas D Pfister, Melinda Hollingshead, Robert J Kinders, Yiping Zhang, Yvonne A Evrard, Jiuping Ji, Sonny A Khin, Suzanne Borgel, Howard Stotler, John Carter, Raymond Divelbiss, Shivaani Kummar, Yves Pommier, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50494 (2012)

Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial demonstrated that nuclear staining of Top1 correlates with chemotherapeutic efficacy. Such a c

Externí odkaz: https://doaj.org/article/fc45c0d607034df99dbf3dba3216402a

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Supplementary Materials from Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays

Autor: Ralph E. Parchment, James H. Doroshow, Joseph E. Tomaszewski, W. Marston Linehan, Donald P. Bottaro, Robert J. Kinders, Thomas D. Pfister, Suzanne Borgel, Yiping Zhang, Jiuping Jay Ji, Sonny A. Khin, Yvonne A. Evrard, Tony Navas, Jennifer Weiner, Melinda G. Hollingshead, Apurva K. Srivastava

Table S1: Summary of analytical characteristics of full-length MET and pMET assays; data collected from assays run with A549, U87, SNU5 and GTL-16 xenograft tumor extracts. Table S2: Measurement of MET and pMET levels in core needle specimens (#1-5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4275f2dc106338b0968102684ac3aa
https://doi.org/10.1158/1078-0432.22457915

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Supplementary Materials from Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

Autor: Yves Pommier, James H. Doroshow, Joseph E. Tomaszewski, Ralph E. Parchment, Robert J. Kinders, Sonny A. Khin, Shalu Gupta, Keli Agama, William C. Reinhold, Thomas D. Pfister

Supplementary Materials from Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96372251957696df91443b758b8f1a1d
https://doi.org/10.1158/1535-7163.22485447.v1

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Data from Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays

Purpose: Rational development of targeted MET inhibitors for cancer treatment requires a quantitative understanding of target pharmacodynamics, including molecular target engagement, mechanism of action, and duration of effect.Experimental Design: Sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cc82bee0797ee2f6ea9a7f0342ca11
https://doi.org/10.1158/1078-0432.c.6523751

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Data from Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

Autor: Yves Pommier, James H. Doroshow, Joseph E. Tomaszewski, Ralph E. Parchment, Robert J. Kinders, Sonny A. Khin, Shalu Gupta, Keli Agama, William C. Reinhold, Thomas D. Pfister

Topoisomerase I (Top1) is a proven target for cancer therapeutics, and the level of Top1 in tumors has been used as a biomarker for chemotherapeutic efficacy. In this study, we report the development and validation of a two-site enzyme chemiluminesce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c9110b51fb94819b35ad70cb68bc11
https://doi.org/10.1158/1535-7163.c.6531945.v1

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supplementary figures from Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays

Figure S1: Specificity of the MET antibodies demonstrated by Western blot analysis. Figure S2: Effect of freeze-thaw cycles and warm vs cold ischemia time on full-length and pMET levels. Figure S3: Inhibition of tumor growth and intratumoral MET phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113c03dc6f2ba086a30ec3d69a8cc619
https://doi.org/10.1158/1078-0432.22457912.v1

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