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Bending-Neutral Deformations of Minimal Surfaces

Autor: Sonnet, André M., Virga, Epifanio G.

Minimal surfaces are ubiquitous in nature. Here they are considered as geometric objects that bear a deformation content. By refining the resolution of the surface deformation gradient afforded by the polar decomposition theorem, we identify a bendin

Externí odkaz: http://arxiv.org/abs/2405.16169

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Design, Synthesis, and In Vitro Antimalarial Evaluation of New 1,3,5-Tris[(4-(Substituted-Aminomethyl)Phenoxy)Methyl]Benzenes

Autor: Sandra Albenque-Rubio, Jean Guillon, Patrice Agnamey, Céline Damiani, Solène Savrimoutou, Romain Mustière, Noël Pinaud, Stéphane Moreau, Jean-Louis Mergny, Luisa Ronga, Ioannis Kanavos, Mathieu Marchivie, Serge Moukha, Pascale Dozolme, Pascal Sonnet, Anita Cohen

Publikováno v: Drugs and Drug Candidates, Vol 3, Iss 3, Pp 615-637 (2024)

By taking into account our previously described series of 1,3,5-tris[(4-(substituted-aminomethyl)phenyl)methyl]benzene compounds, we have now designed, prepared, and evaluated in vitro against Plasmodium falciparum a novel series of structural analog

Externí odkaz: https://doaj.org/article/9dd6625364864c06b8baee9fd5429344

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Indazole–Quinolone Hybrids as Anti-Virulence Agents against Pseudomonas aeruginosa

Autor: Marie Hanot, Marine Duplantier, Céline Dalle, Yani Ren, Sophie Da Nascimento, Jean-Paul Becker, Nicolas Taudon, Elodie Lohou, Pascal Sonnet

Publikováno v: Drugs and Drug Candidates, Vol 3, Iss 3, Pp 512-536 (2024)

Antibiotic resistance is a critical public health issue. Among the multi-drug resistant microorganisms in question, Pseudomonas aeruginosa has been designated by the WHO as a priority threat. Its virulence is orchestrated through quorum sensing (QS).

Externí odkaz: https://doaj.org/article/d8b2148a39ea41a1931499b4b494f3a8

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Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas

Autor: Mikhael D. Manurung, Friederike Sonnet, Marie-Astrid Hoogerwerf, Jacqueline J. Janse, Yvonne Kruize, Laura de Bes-Roeleveld, Marion König, Alex Loukas, Benjamin G. Dewals, Taniawati Supali, Simon P. Jochems, Meta Roestenberg, Mariateresa Coppola, Maria Yazdanbakhsh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Hookworm infection remains a significant public health concern, particularly in low- and middle-income countries, where mass drug administration has not stopped reinfection. Developing a vaccine is crucial to complement current control measu

Externí odkaz: https://doaj.org/article/05bd151b8941483d9f54e82d436f3566

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Applying a hierarchical Bayesian framework to reveal how fear and animal ownership drive human's valuation of and interactions with coyotes

Autor: Kimberly Rivera, Carlos Garcia‐Quijano, Virginie Sonnet, Brian D. Gerber

Publikováno v: Conservation Science and Practice, Vol 6, Iss 9, Pp n/a-n/a (2024)

Abstract Human dimensions research is valuable to managing human‐wildlife interactions, especially in urban environments where such interactions are common. Survey data, which commonly contain Likert scales and questions, are useful in this field;

Externí odkaz: https://doaj.org/article/23734d615e3b455aaac88c376d116594

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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

Publikováno v: eLife, Vol 12 (2024)

The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR ac

Externí odkaz: https://doaj.org/article/6521500dd1424027bebffc6920eba56b

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Model for Photoresponsive Nematic Elastomers

Autor: Sonnet, André M., Virga, Epifanio G.

We study the equilibria of a photoresponsive nematic elastomer ribbon within a continuum theory that builds upon the statistical mechanics model put forward by Corbett and Warner [Phys. Rev. E 78, 061701 (2008)]. We prove that the spontaneous deforma

Externí odkaz: http://arxiv.org/abs/2208.13914

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Validation of reference genes for cardiac RT-qPCR studies spanning the fetal to adult period

Autor: Karthikeyan Bose, Samantha Louey, Sonnet S. Jonker

Publikováno v: MethodsX, Vol 13, Iss , Pp 103042- (2024)

Many genes used as internal controls for mRNA expression studies are unstable (change) over development. This study determined an approach to validate reference genes for mRNA studies spanning the fetal period to adulthood in sheep hearts. • We det

Externí odkaz: https://doaj.org/article/b6232014f2744985a20bbf760b305d98

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