Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.

Autor: Pasquier B; Oncology Drug Discovery, ‡Drug Disposition and Safety, §Structure Design Informatics and Structural Biology, ∥Pharmaceutical Sciences Operations, ⊥Protein Production, and #Global Biotherapeutic, Sanofi , 13 Quai Jules Guesde, 94403 Vitry-sur-Seine, France., El-Ahmad Y, Filoche-Rommé B, Dureuil C, Fassy F, Abecassis PY, Mathieu M, Bertrand T, Benard T, Barrière C, El Batti S, Letallec JP, Sonnefraud V, Brollo M, Delbarre L, Loyau V, Pilorge F, Bertin L, Richepin P, Arigon J, Labrosse JR, Clément J, Durand F, Combet R, Perraut P, Leroy V, Gay F, Lefrançois D, Bretin F, Marquette JP, Michot N, Caron A, Castell C, Schio L, McCort G, Goulaouic H, Garcia-Echeverria C, Ronan B

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Jan 08; Vol. 58 (1), pp. 376-400. Date of Electronic Publication: 2014 Nov 26.

Class III PI3K Biology.

Autor: Caux M; Inserm U1297 and Paul Sabatier University, Institute of Cardiovascular and Metabolic Diseases, I2MC, 31432, Toulouse, France., Chicanne G; Inserm U1297 and Paul Sabatier University, Institute of Cardiovascular and Metabolic Diseases, I2MC, 31432, Toulouse, France., Severin S; Inserm U1297 and Paul Sabatier University, Institute of Cardiovascular and Metabolic Diseases, I2MC, 31432, Toulouse, France. sonia.severin@inserm.fr.

Publikováno v: Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2022; Vol. 436, pp. 69-93.

Comprehensive Heterocyclic Chemistry IV

Comprehensive Heterocyclic Chemistry IV provides a first point of entry for scientists interested in heterocyclic ring systems. Given the rapid expansion of publications in this field, this compilation of definitive reviews is especially important an