Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.

Autor: Heidrun Hirner, Cagatay Günes, Joachim Bischof, Sonja Wolff, Arnhild Grothey, Marion Kühl, Franz Oswald, Florian Wegwitz, Michael R Bösl, Anna Trauzold, Doris Henne-Bruns, Christian Peifer, Frank Leithäuser, Wolfgang Deppert, Uwe Knippschild

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29709 (2012)

Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular kinases, among them members of the CK1 family, play an important role in modulating the transf

Externí odkaz: https://doaj.org/article/6c146078ced546758b3690d263e2f982

Supplementary Legends 1-8 from p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

Autor: Matthias Dobbelstein, Claus L. Andersen, Torben F. Ørntoft, Troels Schepeler, Ute M. Moll, Sonja Wolff, Irina Savelyeva, Xin Zhang, Christian J. Braun

Supplementary Legends 1-8 from p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1508d0c1d14b065def6f52e514cb0261
https://doi.org/10.1158/0008-5472.22375872.v1

The alpha/beta carboxyterminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins

Autor: Ute M. Moll, Flaminia Talos, Sonja Wolff, Ulrike Beyer, Gustavo Palacios, Matthias Dobbelstein

Publikováno v: Cell death and differentiation
Wolff, S, Talos, F, Palacios, G, Beyer, U, Dobbelstein, M & Moll, U M 2009, ' The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins ', Cell Death and Differentiation, vol. 16, no. 8, pp. 1108-17 . https://doi.org/10.1038/cdd.2009.25

Udgivelsesdato: 2009-Aug p63, an ancestral transcription factor of the p53 family, has three C-terminal isoforms whose relative in vivo functions are elusive. The p63 gene is essential for skin and limb development, as vividly shown by two independen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a69f82e460fb1a00d1c9f3bbc4004a
http://europepmc.org/articles/PMC2778344

Transcription-independent pro-apoptotic functions of p53

Autor: Ute M. Moll, Daniel Speidel, Wolfgang Deppert, Sonja Wolff

Publikováno v: Current Opinion in Cell Biology. 17:631-636

Induction of apoptosis is one of the central activities by which p53 exerts its tumor-suppressing function. Aside from its primary function as a transcription factor, it can promote apoptosis independent of transcription. Recent studies have started

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501c5ae91544263a77b27eda0cf2344a
https://doi.org/10.1016/j.ceb.2005.09.007

The Role of the Casein Kinase 1 (CK1) Family in Different Signaling Pathways Linked to Cancer Development

Autor: Thorsten Eismann, Claas Brockschmidt, Peter Uwe Würl, Uwe Knippschild, Martin Stöter, Sonja Wolff, Mathias Wittau, Georgios Giamas

Publikováno v: Oncology Research and Treatment. 28:508-514

The members of the casein kinase 1 (CK1) family are highly conserved and are expressed in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f67bf38ae56b387e3d644ac624de3e
https://doi.org/10.1159/000087137