Next generation L2-based HPV vaccines cross-protect against cutaneous papillomavirus infection and tumor development

Autor: Melinda Ahmels, Filipe C. Mariz, Ilona Braspenning-Wesch, Sonja Stephan, Bettina Huber, Gabriele Schmidt, Rui Cao, Martin Müller, Reinhard Kirnbauer, Frank Rösl, Daniel Hasche

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Licensed L1-VLP-based immunizations against high-risk mucosal human papillomavirus (HPV) types have been a great success in reducing anogenital cancers, although they are limited in their cross-protection against HPV types not covered by the vaccine.

Externí odkaz: https://doaj.org/article/44029ba109ca4877b30f988ba8430789

Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity

Autor: Yingying Fu, Rui Cao, Miriam Schäfer, Sonja Stephan, Ilona Braspenning-Wesch, Laura Schmitt, Ralf Bischoff, Martin Müller, Kai Schäfer, Sabrina E Vinzón, Frank Rösl, Daniel Hasche

Publikováno v: eLife, Vol 9 (2020)

Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with

Externí odkaz: https://doaj.org/article/d8b9e86c43164c898431dd97d6ecd671

Establishment of an Immortalized Skin Keratinocyte Cell Line Derived from the Animal Model Mastomys coucha.

Autor: Daniel Hasche, Sonja Stephan, Larissa Savelyeva, Frank Westermann, Frank Rösl, Sabrina E Vinzón

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161283 (2016)

In the present report we describe the establishment of a spontaneous immortalized skin keratinocyte cell line derived from the skin of the multimammate rodent Mastomys coucha. These animals are used in preclinical studies for a variety of human disea

Externí odkaz: https://doaj.org/article/9baed6adca124fd5b770dea769321eee

Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity

Autor: Daniel Hasche, Ilona Braspenning-Wesch, Ralf Bischoff, Laura Schmitt, Sabrina E. Vinzón, Rui Cao, Sonja Stephan, Kai Schäfer, Yingying Fu, Miriam Schäfer, Martin Müller, Frank Rösl

Publikováno v: eLife, Vol 9 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
eLife

Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6069ec706f3b914c61290a4252b8b7e
https://elifesciences.org/articles/57626

The interplay of UV and cutaneous papillomavirus infection in skin cancer development

Autor: Sonja Stephan, Martina Niebler, Daniel Hasche, Ilona Braspenning-Wesch, Frank Rösl, Sabrina E. Vinzón, Christa Flechtenmacher, Hermann Josef Gröne, Baki Akgül, Julita Mikulec

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 11, p e1006723 (2017)

Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma skin cancer (NMSC) development, especially in association with UVB. Extensively studied transgenic mouse models failed to mimic all aspects of virus-host interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796f45f9a0dcd1902b784ab05db6f6a7
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006723