Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Sonja Stölzle-Feix"'
1
Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
Autor: Sonja Stölzle-Feix, Niels Fertig, Michael George, Marta Lemme, Elena Dragicevic, Ulrich Thomas, Peter Linder, Matthias Gossmann, Bettina Lickiss
Publikováno v: Journal of visualized experiments : JoVE. (188)
Cardiac contractility assessment is of immense importance for the development of new therapeutics and their safe transition into clinical stages. While human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold promise to serve as a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010c5bd02a409f8654a97abb12527683
https://pubmed.ncbi.nlm.nih.gov/36342136
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3
The opioid oxycodone use‐dependently inhibits the cardiac sodium channel Na V 1.5
Autor: Krisztina Juhasz, Vera Peuckmann-Post, Angelika Lampert, Sonja Stölzle-Feix, Roman Rolke, Jannis E. Meents
Publikováno v: British Journal of Pharmacology. 175:3007-3020
BACKGROUND AND PURPOSE: Oxycodone is a potent semi‐synthetic opioid that is commonly used for the treatment of severe acute and chronic pain. However, treatment with oxycodone can lead to cardiac electrical changes, such as long QT syndrome, potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f20f1b1ccc74fddda1509063710b894
https://doi.org/10.1111/bph.14348
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4
An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery
Autor: Nina Brinkwirth, Andrea Brüggemann, Michael George, Nadine Becker, Claudia Haarmann, Markus Rapedius, Ilka Rinke-Weiß, Sonja Stölzle-Feix, Niels Fertig, Søren Friis, Alison Obergrussberger, Tom A. Goetze
Publikováno v: Expert opinion on drug discovery. 13(3)
Automated patch clamp (APC) devices have become commonplace in many industrial and academic labs. Their ease-of-use and flexibility have ensured that users can perform routine screening experiments and complex kinetic experiments on the same device w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f053e5d6190d1fbbb528e2d5aebae34
https://pubmed.ncbi.nlm.nih.gov/29343120
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5
Novel screening techniques for ion channel targeting drugs
Autor: Sonja Stölzle-Feix, Nadine Becker, Alison Obergrussberger, Andrea Brüggemann, Clemens Möller, Niels Fertig
Publikováno v: Channels
Ion channels are integral membrane proteins that regulate the flux of ions across the cell membrane. They are involved in nearly all physiological processes, and malfunction of ion channels has been linked to many diseases. Until recently, high-throu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2d55d35260852adabdde2d95a3d964
http://europepmc.org/articles/PMC4850050
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8
Comprehensive Cardiac Safety Screening: Pharmacology of Stem Cell-Derived Cardiomyocytes using High-Throughput Automated Patch Clamp
Autor: Andrea Brueggemann, Ilka Rinke, Sonja Stölzle-Feix, Michael George, Timo Stengel, Niels Fertig, Markus Rapedius, Claudia Haarmann, Tom Götze, Nadine Becker
Publikováno v: Biophysical Journal. 110(3)
Drug discovery is challenged by poor predictability of proarrhythmic effects of present safety screening approaches. The Comprehensive in Vitro Proarrhythmia Assay (CiPA), an FDA-directed initiative, is specifically focused on improved preclinical as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595c236715db9f0f1cf62ebd74b01fd0
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9
Safety pharmacology studies using EFP and impedance
Autor: Alison Obergrussberger, Krisztina Juhasz, Ulrich Thomas, Michael George, Corina Bot, Niels Fertig, Nadine Becker, Leo Dörr, Matthias Beckler, Sonja Stölzle-Feix
Publikováno v: Journal of pharmacological and toxicological methods. 81
Introduction While extracellular field potential (EFP) recordings using multi-electrode arrays (MEAs) are a well-established technique for monitoring changes in cardiac and neuronal function, impedance is a relatively unexploited technology. The comb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd53e0a8d1aa931167de161d2eb6f00
https://pubmed.ncbi.nlm.nih.gov/27084108
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