Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sonja Ortler"'
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Efficacy and safety of human monoclonal antibody erenumab used for migraine prophylaxis have been shown in clinical studies. APOLLON is an open-label, multi-center, single arm study, which permits dose adjustments of erenumab and
Externí odkaz:
https://doaj.org/article/e6ecff1ce47745e68f685768d79638bf
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10800 (2010)
BackgroundDendritic cells (DC) can act tolerogenic at a semi-mature stage by induction of protective CD4(+) T cell and NKT cell responses.Methodology/principal findingsHere we studied the role of the co-inhibitory molecule B7-H1 (PD-L1, CD274) on sem
Externí odkaz:
https://doaj.org/article/b31f1ec16bec437daa228ad4988f7213
Publikováno v:
European Journal of Immunology. 39:1536-1543
DC in the CNS have emerged as the major rate-limiting factor for immune invasion and subsequent neuroinflammation during EAE. The mechanism of how this is regulated by brain-localized DC remains unknown. Here, we describe the ability of brain-localiz
Autor:
Heinz Wiendl, Kerstin Göbel, Klaus-Armin Nave, Chi Wang Ip, Rudolf Martini, Antje Kroner, Mathias Mäurer, Sonja Ortler, Nicholas Schwab
Publikováno v:
The American Journal of Pathology. 174:2290-2299
It is assumed that the onset and course of autoimmune inflammatory central nervous system (CNS) disorders (eg, multiple sclerosis) are influenced by factors that afflict immune regulation as well as CNS vulnerability. We challenged this concept exper
Autor:
Zsuzsanna Fabry, Alla L. Zozulya, Sonja Ortler, Christian Weidenfeller, Matyas Sandor, Heinz Wiendl, JangEun Lee
Publikováno v:
The Journal of Neuroscience. 29:140-152
Dendritic cells (DCs) appear in higher numbers within the CNS as a consequence of inflammation associated with autoimmune disorders, such as multiple sclerosis, but the contribution of these cells to the outcome of disease is not yet clear. Here, we
Autor:
Sonja Ortler, Christoph Leder, Lieping Chen, Alla L. Zozulya, Antje Kroner, Percy A. Knolle, Heinz Wiendl, Michel Mittelbronn
Publikováno v:
European Journal of Immunology. 38:1734-1744
The co-inhibitory B7-homologue 1 (B7-H1/PD-L1) influences adaptive immune responses and has been proposed to contribute to the mechanisms maintaining peripheral tolerance and limiting inflammatory damage in parenchymal organs. To understand the B7-H1
Publikováno v:
The Journal of Neuroscience Nursing
Multiple sclerosis (MS), a chronic demyelinating and neurodegenerative disorder of the central nervous system (Bennett & Stuve, 2009), results in various locomotor, sensory, and cognitive impairments (Keegan & Noseworthy, 2002). The course of the dis
Multiple sclerosis (MS) is a chronic immune-mediated, central nervous system (CNS) demyelinating disease. Clinical and histopathological features suggest an inflammatory etiology involving resident CNS innate cells as well as invading adaptive immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36857b3cb8520f02a460e6722c05c41
https://europepmc.org/articles/PMC2869392/
https://europepmc.org/articles/PMC2869392/
Autor:
Sonja Ortler, Susanna Cardell, Carolin Brandl, Manfred B. Lutz, Heinz Wiendl, Thomas Herrmann
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 5, p e10800 (2010)
PLoS ONE, Vol 5, Iss 5, p e10800 (2010)
BackgroundDendritic cells (DC) can act tolerogenic at a semi-mature stage by induction of protective CD4(+) T cell and NKT cell responses.Methodology/principal findingsHere we studied the role of the co-inhibitory molecule B7-H1 (PD-L1, CD274) on sem
Autor:
Sven G. Meuth, Nurcan Üçeyler, Kerstin Göbel, Christoph Kleinschnitz, Guido Stoll, Claudia Sommer, Heinz Wiendl, Sonja Ortler
Publikováno v:
Experimental neurology. 222(1)
Peripheral nerve injury induces a profound local inflammatory response that involves T cells and macrophages and augments the generation of neuropathic pain. The mechanisms underlying immune cell activation or inhibition in the peripheral nervous sys