Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sonja Offner"'
Autor:
Francesca Ros, Sonja Offner, Stefan Klostermann, Irmgard Thorey, Helmut Niersbach, Sebastian Breuer, Grit Zarnt, Stefan Lorenz, Juergen Puels, Basile Siewe, Nicole Schueler, Tajana Dragicevic, Dominique Ostler, Imke Hansen-Wester, Valeria Lifke, Brigitte Kaluza, Klaus Kaluza, Wim van Schooten, Roland Buelow, Alain C Tissot, Josef Platzer
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been estab
Externí odkaz:
https://doaj.org/article/eb4cfd37c8a244a096d64b9303c73a7f
Autor:
Stefan Seeber, Francesca Ros, Irmgard Thorey, Georg Tiefenthaler, Klaus Kaluza, Valeria Lifke, Jens André Alexander Fischer, Stefan Klostermann, Josef Endl, Erhard Kopetzki, Achal Pashine, Basile Siewe, Brigitte Kaluza, Josef Platzer, Sonja Offner
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86184 (2014)
We have developed a robust platform to generate and functionally characterize rabbit-derived antibodies using B cells from peripheral blood. The rapid high throughput procedure generates a diverse set of antibodies, yet requires only few animals to b
Externí odkaz:
https://doaj.org/article/121e8ae00e8c4eaa9913c08d88a77bdd
Autor:
Tatiana Flisikowska, Irmgard S Thorey, Sonja Offner, Francesca Ros, Valeria Lifke, Bryan Zeitler, Oswald Rottmann, Anna Vincent, Lei Zhang, Shirin Jenkins, Helmut Niersbach, Alexander J Kind, Philip D Gregory, Angelika E Schnieke, Josef Platzer
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21045 (2011)
Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and als
Externí odkaz:
https://doaj.org/article/28865b2f7cbb4665ba7b4622b6f2e4fd
Autor:
Klaus Kaluza, Sebastian Breuer, Roland Buelow, Grit Zarnt, Nicole Schueler, Valeria Lifke, Basile Siewe, Alain Tissot, Irmgard Thorey, Stefan Lorenz, Dominique Ostler, Josef Platzer, Brigitte Kaluza, Francesca Ros, Juergen Puels, Tajana Dragicevic, Sonja Offner, Imke Hansen-Wester, Stefan Klostermann, Helmut Niersbach, Wim Van Schooten
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae469eda72b88cfe4091b276cee737e9
https://doi.org/10.1080/19420862.2020.1846900
https://doi.org/10.1080/19420862.2020.1846900
Autor:
Marco Boettger, Jens Fischer, Christophe Boetsch, Juha Lindner, Jörg Benz, Friederike Hesse, Mario Perro, Marta Cañamero, Pablo Umana, Guy Georges, Patrick Alexander Aaron Weber, Victor Levitsky, Standford Chen, Adrian Zwick, Alexander Bujotzek, Merlind Muecke, Henry Kao, Stefanie Bendels, Georg Fertig, Stephane Leclair, Laura Codarri Deak, Matthias Fueth, Valeria Lifke, Stefan Dengl, Christian Klein, Sonja Offner, Sara Colombetti, Stefan Seeber, Laura Lauener
Publikováno v:
Cancer Research. 80:2270-2270
Based on the unprecedented clinical efficacy of PD-1/PD-L1 pathway checkpoint inhibitors (CPI), non-redundant immune checkpoints like TIM-3, LAG-3, TIGIT or BTLA are currently being targeted, by combinatorial approaches using monospecific or bispecif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ed33840c8d4086a4a38cca3d1c4af9
https://doi.org/10.1158/1538-7445.am2020-2270
https://doi.org/10.1158/1538-7445.am2020-2270
Autor:
Bernd Schlereth, Mathias Locher, Pauline Wimberger, Benjamin Guller, Thomas Urbig, Sonja Offner, Ralf Lutterbuese, Robert Hofmeister, Andreas Wolf, Iduna Fichtner, Antonio J. da Silva, Rainer Kimmig, Tobias Raum, Peter Kufer, Klaus Brischwein, Carola Steiger, Petra Kleindienst, Patrick A. Baeuerle
Publikováno v:
Molecular Immunology. 43:1129-1143
We have developed a novel single-chain Ep-CAM-/CD3-bispecific single-chain antibody construct designated MT110. MT110 redirected unstimulated human peripheral T cells to induce the specific lysis of every Ep-CAM-expressing tumor cell line tested. MT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d079643e094e9acea1fe2996e2093e
https://doi.org/10.1016/j.molimm.2005.07.034
https://doi.org/10.1016/j.molimm.2005.07.034
Publikováno v:
Molecular Immunology. 43:763-771
Certain bispecific single-chain antibody constructs exhibit an extraordinary potency for polyclonal T cell engagement and target cell lysis. Here we studied the structural basis for this potency, using laser scanning confocal microscopy. Cytolytic hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53956bbf9fac4de2a960cdd7cfa57c8e
https://doi.org/10.1016/j.molimm.2005.03.007
https://doi.org/10.1016/j.molimm.2005.03.007
Autor:
Susanne Weinberger, Christian Itin, Peter Kufer, Birgit Kohleisen, Patrick A. Baeuerle, Sonja Offner, Armin Hekele, Ulrike Teichmann, Susanne Gross
Publikováno v:
Cancer Immunology, Immunotherapy. 54:431-445
Recombinant monoclonal antibodies are beginning to revolutionize cancer therapy. In combination with standard chemotherapy, high response rates have been reported with antibodies of the human IgG1 isotype for treatment of non-Hodgkin's lymphoma and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1913a160062f4394734497d3c5232bfb
https://doi.org/10.1007/s00262-004-0613-x
https://doi.org/10.1007/s00262-004-0613-x
Autor:
Valeria Lifke, Brigitte Kaluza, Klaus Kaluza, Stefan Seeber, Sonja Offner, Georg Tiefenthaler, Basile Siewe, Josef Endl, Irmgard Thorey, Jens Fischer, Achal Pashine, Stefan Klostermann, Erhard Kopetzki, Francesca Ros, Josef Platzer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e86184 (2014)
PLoS ONE, Vol 9, Iss 2, p e86184 (2014)
We have developed a robust platform to generate and functionally characterize rabbit-derived antibodies using B cells from peripheral blood. The rapid high throughput procedure generates a diverse set of antibodies, yet requires only few animals to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3299c7a1a1864bef0db37deff810b6e9
http://europepmc.org/articles/PMC3913575
http://europepmc.org/articles/PMC3913575
Publikováno v:
Journal of Bacteriology. 182:4328-4336
The minimal number of genes required for the formation of gas vesicles in halophilic archaea has been determined. Single genes of the 14 gvp genes present in the p-vac region on plasmid pHH1 of Halobacterium salinarum (p- gvpACNO and p- gvpDEFGHIJKLM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bfee33b46a80dcf14e1103d88147b8
https://doi.org/10.1128/jb.182.15.4328-4336.2000
https://doi.org/10.1128/jb.182.15.4328-4336.2000