Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sonja Neumeyer"'
Autor:
Mohamed A. Elhadad, Mónica del C. Gómez-Alonso, Chien-Wei Chen, Sonja Neumeyer, Thomas Delerue, Wolfgang Rathmann, Michael Näbauer, Christa Meisinger, Stefan Kääb, Jochen Seissler, Johannes Graumann, Wolfgang Koenig, Karsten Suhre, Christian Gieger, Uwe Völker, Annette Peters, Elke Hammer, Melanie Waldenberger
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background and aims Atherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics, as a high-throughput method, could provide helpful insights into the pathological mechanis
Externí odkaz:
https://doaj.org/article/27d62746d13f4cb9b09770b2fb66f876
Autor:
Julia Lange de Luna, Aayah Nounu, Sonja Neumeyer, Lucy Sinke, Rory Wilson, Fabian Hellbach, Pamela R. Matías-García, Thomas Delerue, Juliane Winkelmann, Annette Peters, Barbara Thorand, Marian Beekman, Bastiaan T. Heijmans, Eline Slagboom, Christian Gieger, Jakob Linseisen, Melanie Waldenberger
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associa
Externí odkaz:
https://doaj.org/article/0c2d8b5f2bb94eac9bcb5c4861efb66f
Publikováno v:
Cancer Medicine, Vol 12, Iss 16, Pp 17284-17295 (2023)
Abstract Background Cervical cancer (CC) screening is generally recommended until age 65. The incidence of CC could be underestimated, particularly in older women, due to a lack of hysterectomy correction. Furthermore, elderly women (≥65 years) are
Externí odkaz:
https://doaj.org/article/ef42ebebfb4d4697997c4b3a6e86e1d4
Autor:
Arthur Gilly, Young-Chan Park, Grace Png, Andrei Barysenka, Iris Fischer, Thea Bjørnland, Lorraine Southam, Daniel Suveges, Sonja Neumeyer, N. William Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the
Externí odkaz:
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
Autor:
Sonja Neumeyer, Odilia Popanda, Dominic Edelmann, Katja Butterbach, Csaba Toth, Wilfried Roth, Hendrik Bläker, Ruijingfang Jiang, Esther Herpel, Cornelia Jäkel, Peter Schmezer, Lina Jansen, Elizabeth Alwers, Axel Benner, Barbara Burwinkel, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude
Publikováno v:
Epigenetics, Vol 14, Iss 5, Pp 477-493 (2019)
Involvement of sex hormones in colorectal cancer (CRC) development has been linked to oestrogen receptor β (ERβ). Expression of ERβ is found reduced in tumour tissue and inversely related to mortality. However, mechanisms are not well understood.
Externí odkaz:
https://doaj.org/article/c31ee8df21a748cfb7bee0d8c682945e
Autor:
Barbara Burwinkel, Jenny Chang-Claude, Amit Joshi, Esther Herpel, Finlay A. Macrae, Daniel D. Buchanan, Axel Benner, Alexis Ulrich, Sonja I. Berndt, Andrew T. Chan, Manish Gala, Cornelia M. Ulrich, Petra Seibold, Jane C. Figueiredo, Mingyang Song, Sonja Neumeyer, Shuji Ogino, Hendrik Bläker, Aung Ko Win, Graham G. Giles, Polly A. Newcomb, Michael Hoffmeister, Hermann Brenner, Matthias Kloor, John L. Hopper, Lori C. Sakoda, Amanda I. Phipps, Xinwei Hua, Robert E. Schoen, Ulrike Peters, Lina Jansen, Dominique Scherer, Roger L. Milne, Martha L. Slattery, Niels Halama
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer survival. Tregs, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and theref
Autor:
Grace Png, Emmanouil Tsafantakis, Iris Fischer, N. William Rayner, Daniel Suveges, George Dedoussis, Andrei Barysenka, Arthur Gilly, Sonja Neumeyer, Lorraine Southam, Thea Bjørnland, Maria Karaleftheri, Young-Chan Park, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257
Autor:
Haifa Maalmi, JoAnn E. Manson, Michael Hoffmeister, Lori C. Sakoda, Sonja I. Berndt, Jane C. Figueiredo, Amit Joshi, Edward Giovannucci, Sonja Neumeyer, Barbara L. Banbury, Katja Butterbach, Ulrike Peters, Aung Ko Win, Emily White, John L. Hopper, Mingyang Song, Peter T. Campbell, Shuji Ogino, Martha L. Slattery, Robert E. Schoen, Rowan T. Chlebowski, Marjorie L. McCullough, Jenny Chang-Claude, Hermann Brenner, Finlay A. Macrae, Polly A. Newcomb, Andrew T. Chan
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations in patients with colorectal cancer have been consistently associated with higher mortality in observational studies. It is unclear whether low 25(OH)D levels directly influence colore
Publikováno v:
Trends Mol. Med. 26, 232-241 (2020)
Large genome-wide association studies (GWAS) have identified loci that are associated with complex traits and diseases, but index variants are often not causal and reside in non-coding regions of the genome. To gain a better understanding of the rele
Autor:
Dominic Edelmann, Katja Butterbach, Hendrik Bläker, Wilfried Roth, Axel Benner, Michael Hoffmeister, Hermann Brenner, Barbara Burwinkel, Esther Herpel, Odilia Popanda, Peter Schmezer, Sonja Neumeyer, Csaba Toth, Jenny Chang-Claude, Cornelia Jäkel
Publikováno v:
Epigenomics. 11:1765-1778
Aim: Use of menopausal hormone therapy (MHT) has been associated with a reduced risk for colorectal cancer, but mechanisms underlying this relationship are not well understood. In the colon, MHT appears to act through estrogen receptor β (ERβ) whic