CD141+ dendritic cells produce prominent amounts of IFN-a after dsRNA recognition and can be targeted via DEC-205 in humanized mice

Autor: Ralph M. Steinman, Maggi Pack, Liliana D. Vanoaica, Jürgen Schmitz, Gaëlle Breton, Patrick C. Rämer, Christian Münz, Sonja Meixlsperger, Andres M. Salazar, Carol S. Leung, Steve Pascolo, Andrzej Dzionek

Publikováno v: Blood

Functional differences between human dendritic cell (DC) subsets and the potential benefits of targeting them with vaccines remain poorly defined. Here we describe that mice with reconstituted human immune system components (huNSG mice) develop all h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d4c6c1ed47e096409d830a1932fdfc

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

Autor: Eva Hug, Michael Reth, Sonja Meixlsperger, Sebastian Herzog, Hassan Jumaa, Jihye Paik, Ronald A. DePinho

Publikováno v: Nature Immunology. 9:623-631

Although the essential role of the adaptor protein SLP-65 in pre-B cell differentiation is established, the molecular mechanism underlying its function is poorly understood. In this study, we uncover a link between SLP-65-dependent signaling and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77002d11859813faa767be5c2c1679ab
https://doi.org/10.1038/ni.1616

Phenotypical and Functional Properties of Antigen-Presenting Cells Derived from Humanized Mice

Autor: Christian Münz, Maya C. André, Sonja Meixlsperger

Publikováno v: Humanized Mice for HIV Research ISBN: 9781493916542

In vivo reconstitution of the hematopoietic system in NOD/shi-SCID/γcnull (NOG), NOD/SCID/IL2Rγnull (NSG), and BALB/c-Rag2KO/γc null (BRG) mice with human hematopoietic stem cells (humanized mice) allows the generation of antigen-presenting cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0e49b22b34569318ba5f7ed1285e6fa
https://doi.org/10.1007/978-1-4939-1655-9_16

EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors

Autor: Cliona M. Rooney, Patrick C. Rämer, Christian Münz, Jaap M. Middeldorp, Fathima Zumla Cader, John G. Gribben, Martin J. Allday, Barbara Savoldo, Rita Coutinho, Paul Murray, Jamie P. Nourse, Sonja Meixlsperger, Laurie Pinaud, Hazem A. H. Ibrahim, Robert E. White, Csaba Bödör, Maher K. Gandhi, Mark Bower, Kikkeri N. Naresh

Publikováno v: Journal of Clinical Investigation, 122(4), 1487-1502. The American Society for Clinical Investigation
White, R E, Raemer, P C, Naresh, K N, Meixlsperger, S, Pinaud, L, Rooney, C, Savoldo, B, Coutinho, R, Bodor, C, Gribben, J, Ibrahim, H A, Bower, M, Nourse, J P, Gandhi, M K, Middeldorp, J M, Cader, F Z, Murray, P, Munz, C & Allday, M J 2012, ' EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors ', Journal of Clinical Investigation, vol. 122, no. 4, pp. 1487-1502 . https://doi.org/10.1172/JCI58092

Epstein-Barr virus (EBV) persistently infects more than 90% of the human population and is etiologically linked to several B cell malignancies, including Burkitt lymphoma (BL), Hodgkin lymphoma (HL), and diffuse large B cell lymphoma (DLBCL). Despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14008bd879ba93e9ac6802c905100487
http://hdl.handle.net/10044/1/20026

Morbus Crohn--a disease of failing macroautophagy in the immune system?

Autor: Sonja Meixlsperger, Christian Münz

Publikováno v: International immunology. 21(11)

Mutations in genes involved in macroautophagy have been found to be associated with Morbus Crohn, also called Crohn's disease (CD), an inflammatory bowel disease. Taking this disease as an example for pathogenesis due to altered macroautophagy, we di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975d11b7356f6297b9ef55465739b48f
https://pubmed.ncbi.nlm.nih.gov/19762453