A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β

Autor: Olga Ucar, Kaiyong Li, Dmytro Dvornikov, Clemens Kreutz, Jens Timmer, Sonja Matt, Lukas Brenner, Catherine Smedley, Mark A. Travis, Thomas G. Hofmann, Ursula Klingmüller, Bruno Kyewski

Publikováno v: Cell Reports, Vol 17, Iss 2, Pp 448-457 (2016)

Adult tissue-specific stem cells (SCs) mediate tissue homeostasis and regeneration and can give rise to all lineages in the corresponding tissue, similar to the early progenitors that generate organs in the first place. However, the developmental ori

Externí odkaz: https://doaj.org/article/8d995da16e3c4c9191e2d68c8b6891ca

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β

Autor: Bruno Kyewski, Ursula Klingmüller, Clemens Kreutz, Dmytro Dvornikov, Lukas Brenner, Olga Ucar, Catherine Smedley, Mark A. Travis, Jens Timmer, Sonja Matt, Thomas G. Hofmann, Kaiyong Li

Publikováno v: Cell Reports
Ucar, O, Li, K, Dvornikov, D, Kreutz, C, Timmer, J, Matt, S, Brenner, L, Smedley, C, Travis, M, Hofmann, T G, Klingmüller, U & Kyewski, B 2016, ' A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β ', Cell Reports, vol. 17, no. 2, pp. 448-457 . https://doi.org/10.1016/j.celrep.2016.09.027
Cell Reports, Vol 17, Iss 2, Pp 448-457 (2016)

Summary Adult tissue-specific stem cells (SCs) mediate tissue homeostasis and regeneration and can give rise to all lineages in the corresponding tissue, similar to the early progenitors that generate organs in the first place. However, the developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ff3d1a7381013d6399bd60c895748f
https://doi.org/10.1016/j.celrep.2016.09.027

Crosstalk between p53 modifiers at PML bodies

Autor: Thomas G. Hofmann, Sonja Matt

Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage. Regulation of p53 activity by post-translational modifications has been linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d9126e8f5961f8c92c5e28c0c3e0a4
https://europepmc.org/articles/PMC6150047/

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

Autor: M. Liebl, Thomas G. Hofmann, M. Meister, S. Schumacher, Christoph Herbel, Sonja Matt, Eva Krieghoff-Henning, V. Greiner, Nadja Bitomsky, E. Conrad, B. Kriznik, Tilman Polonio-Vallon

Publikováno v: Cell Death and Differentiation

Upon severe DNA damage a cellular signalling network initiates a cell death response through activating tumour suppressor p53 in association with promyelocytic leukaemia (PML) nuclear bodies. The deacetylase Sirtuin 1 (SIRT1) suppresses cell death af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb63bafb4af070b088b353ec8866d95
https://doi.org/10.1038/cdd.2015.75

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells

Autor: Bruno Kyewski, Sonja Matt, Kristin Rattay, Janine Claude, Esmail Rezavandy, Jens Derbinski, Thomas G. Hofmann

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 194(3)

Promiscuous expression of a plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays an essential role in T cell tolerance. Although the cellular mechanisms by which promiscuous gene expression (pGE) imposes T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0405867650f7b66a9e6eba6bd7b97203
https://pubmed.ncbi.nlm.nih.gov/25552543