Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sonja Lj. Joksimovic"'
Autor:
Sonja Lj. Joksimovic, J. Grayson Evans, William E. McIntire, Peihan Orestes, Paula Q. Barrett, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Our previous studies implicated glycosylation of the CaV3.2 isoform of T-type Ca2+ channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms underlying the modulation
Externí odkaz:
https://doaj.org/article/9ccc9c7e8875442c83d807ce0d40535f
Autor:
Jelena Klawitter, Touraj Shokati, Weibke Weissenborn, Slobodan M. Todorovic, MacKenzie Walz, Jost Klawitter, Cristina Sempio, Matthew Jackson, Sonja Lj. Joksimovic, Uwe Christians, Ingo Just
Introduction. β-Caryophyllene (BCP) has been shown to be an effective anti-inflammatory agent in chronic and inflammatory pain models. Since limited data are available for BCP in acute pain, we tested efficacy of BCP in an acute post-surgical pain m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52f3a2468f56c93f9f613590c40af91a
https://doi.org/10.22541/au.162539258.80061327/v1
https://doi.org/10.22541/au.162539258.80061327/v1
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Our previous studies have implicated CaV3.2 isoform of T-type Ca2+ channels (T-channels) in the development of postsurgical pain. We have also previously established that different T-channel antagonists can alleviate in vivo postsurgical pain. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52079dc3d8c29729148c0cbbde8c9282
https://pubmed.ncbi.nlm.nih.gov/33843451
https://pubmed.ncbi.nlm.nih.gov/33843451
Publikováno v:
Channels
Voltage-activated calcium channels play an important role in excitability of sensory nociceptive neurons in acute and chronic pain models. We have previously shown that low-voltage-activated calcium channels, or T-type channels (T-channels), increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e886d7d85b37cd3844fb362c5f092a94
https://doi.org/10.1080/19336950.2018.1564420
https://doi.org/10.1080/19336950.2018.1564420
Autor:
Peter W. Reeh, Tal Hoffmann, Slobodan M. Todorovic, Susanne K. Sauer, Katrin Kistner, Sonja Lj. Joksimovic
Publikováno v:
Exp Neurol
Painful diabetic neuropathy occurs in approximately 20% of diabetic patients with underlying pathomechanisms not fully understood. We evaluated the contribution of the Ca(V)3.2 isoform of T-type calcium channel to hyperglycemia-induced changes in cut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a657baaef4b35a3a42784791e32628
https://doi.org/10.1016/j.expneurol.2021.113838
https://doi.org/10.1016/j.expneurol.2021.113838
Autor:
Srdjan M. Joksimovic, Paco S. Herson, James E. Orfila, Michael R. DiGruccio, Yukitoshi Izumi, Charles F. Zorumski, Pierce Eggan, Vesna Jevtovic-Todorovic, Sonja Lj. Joksimovic, Slobodan M. Todorovic, Vesna Tesic, Robert M. Dietz
Publikováno v:
The Journal of Physiology. 595:6327-6348
Several studies suggest that voltage-gated calcium currents are involved in generating high frequency burst firing in the subiculum, but the exact nature of these currents remains unknown. Here, we used selective pharmacology, molecular and genetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c77fdf7c027f84acd7f88187952dc6b
https://doi.org/10.1113/jp274565
https://doi.org/10.1113/jp274565
Autor:
Francesca M. Manzella, Yogendra H. Raol, Sonja Lj. Joksimovic, Douglas F. Covey, Betelehem Asnake, Srdjan M. Joksimovic, Vesna Jevtovic-Todorovic, Kathiresan Krishnan, Peihan Orestes, Slobodan M. Todorovic
Publikováno v:
British Journal of Pharmacology
Br J Pharmacol
Br J Pharmacol
Background and purpose Neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) is a novel hypnotic and voltage-dependent blocker of T-type calcium channels. Here, we examine its potential analgesic effects and adjuvant anaesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331e0ae895d05b37fcefdac82c53952b
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3610
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3610
Autor:
Agustin Garcia-Caballero, Slobodan M. Todorovic, Srdjan M. Joksimovic, Sonja Lj. Joksimovic, Gerald W. Zamponi, Vesna Jevtovic-Todorovic, Simon Feseha, Vesna Tesic
Pain-sensing sensory neurons of the dorsal root ganglion (DRG) can become sensitized (hyperexcitable) in response to surgically-induced peripheral tissue injury. However, the potential role and molecular mechanisms of nociceptive ion channel dysregul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc14e68971599f175113df0ba055148c
https://europepmc.org/articles/PMC6193449/
https://europepmc.org/articles/PMC6193449/
Autor:
Charles F. Zorumski, Yukitoshi Izumi, Sonja Lj. Joksimovic, Douglas F. Covey, Betelehem Asnake, Srdjan M. Joksimovic, Vesna Tesic, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic, Kathiresan Krishnan
Publikováno v:
Br J Anaesth
Background Hypnotics and general anaesthetics impair memory by altering hippocampal synaptic plasticity. We recently reported on a neurosteroid analogue with potent hypnotic activity [(3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile; 3β-OH], which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3471b13c19cde4fc5a33746c550a2ec7
https://pubmed.ncbi.nlm.nih.gov/30916017
https://pubmed.ncbi.nlm.nih.gov/30916017