Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sonja Lindinger"'
Autor:
Lena Maltan, Sarah Weiß, Hadil Najjar, Melanie Leopold, Sonja Lindinger, Carmen Höglinger, Lorenz Höbarth, Matthias Sallinger, Herwig Grabmayr, Sascha Berlansky, Denis Krivic, Valentina Hopl, Anna Blaimschein, Marc Fahrner, Irene Frischauf, Adéla Tiffner, Isabella Derler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The Ca2+ ion channel Orai1 is crucial in immune cells. Here, the authors applied genetic code expansion to transfer light-sensitivity to the Orai1 channel and achieved precise control over its function.
Externí odkaz:
https://doaj.org/article/bee2dd102ac04d1e8838711cbc3c5162
Autor:
Christina Humer, Tamara Radiskovic, Kata Horváti, Sonja Lindinger, Klaus Groschner, Christoph Romanin, Carmen Höglinger
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 618 (2024)
The epithelial ion channel TRPV6 plays a pivotal role in calcium homeostasis. Channel function is intricately regulated at different stages, involving the lipid phosphatidylinositol-4,5-bisphosphate (PIP2). Given that dysregulation of TRPV6 is associ
Externí odkaz:
https://doaj.org/article/c30678cd72bc4e5899e2281a57c2bd48
Autor:
Christopher A. Odhams, Amy L. Roberts, Susan K. Vester, Carolina S. T. Duarte, Charlie T. Beales, Alexander J. Clarke, Sonja Lindinger, Samuel J. Daffern, Antonino Zito, Lingyan Chen, Leonardo L. Jones, Lora Boteva, David L. Morris, Kerrin S. Small, Michelle M. A. Fernando, Deborah S. Cunninghame Graham, Timothy J. Vyse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells t
Externí odkaz:
https://doaj.org/article/26e43468667241ccb8271a65e26175aa
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 804 (2022)
The highly calcium-selective transient receptor potential vanilloid-type channel TRPV6 is important for epithelial Ca2+ transport. Proper regulation of the inherently constitutively active TRPV6 channels is intricate in preserving Ca2+ homeostasis, w
Externí odkaz:
https://doaj.org/article/ebe12a0c3d8e4f428e80ae637054e44d
Autor:
Rajesh Bhardwaj, Christoph Romanin, Jean-Louis Reymond, Aline Lucie Carrel, Roberto Parise-Filho, Micael Rodrigues Cunha, Matthias A. Hediger, Sonja Lindinger
Publikováno v:
RSC Medicinal Chemistry
Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Natural product derived analogues were surveyed, and an oxygenated analog was identified as a potent and selective TRPV6 inhibitor, with high microsomal stability and low off-target effects.
Transient receptor potential vanilloid 6 (TRPV6) is a
Transient receptor potential vanilloid 6 (TRPV6) is a
Autor:
Sonja Lindinger, Saurabh Pandey, Adéla Tiffner, Isabella Derler, Michael Stadlbauer, Victoria Lunz, Daniel Bonhenry, Rudi Ettrich, Irene Frischauf, Matthias Sallinger, Marc Fahrner, Christoph Romanin, Lena Maltan, Sascha Berlansky, Rainer Schindl, Romana Schober, Carmen Hoeglinger
The initial activation step in gating of ubiquitously expressed Orai1 Calcium (Ca2+) ion channels represents the store-dependent coupling to the Ca2+ sensor protein STIM1. An array of constitutively active Orai1 mutants gave rise to the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a605ab39dd19a2e1115dfd3781cef8
https://doi.org/10.1101/2020.07.16.207183
https://doi.org/10.1101/2020.07.16.207183
Autor:
Matthias A. Hediger, Rajesh Bhardwaj, Micael Rodrigues Cunha, Appu K. Singh, Jean-Louis Reymond, Isabella Derler, Sonja Lindinger, Christoph Romanin, Arthur Neuberger, Gergely Gyimesi, Kirill D. Nadezhdin, Alexander I. Sobolevsky
Publikováno v:
Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; R. Cunha, Micael; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander I. (2020). Inactivation-mimicking block of the epithelial calcium channel TRPV6. Science Advances, 6(48), eabe1508. American Association for the Advancement of Science 10.1126/sciadv.abe1508
Science Advances
Science Advances
Small-molecule piperazine derivatives mimic inactivation by calmodulin to selectively and potently block TRPV6 channels.
Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifacto
Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30d7e52314d72946e9969bc4475962c
Autor:
Carmen, Butorac, Martin, Muik, Isabella, Derler, Michael, Stadlbauer, Victoria, Lunz, Adéla, Krizova, Sonja, Lindinger, Romana, Schober, Irene, Frischauf, Rajesh, Bhardwaj, Matthias A, Hediger, Klaus, Groschner, Christoph, Romanin
Publikováno v:
Cell calcium. 79
Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca
Autor:
Annarita Graziani, Lutz Birnbaumer, Christoph Romanin, Toma N. Glasnov, Niroj Shrestha, Gema Guedes de la Cruz, Sonja Lindinger, Carmen Butorac, Helmut Kubista, Wolfgang F. Graier, Marc Freichel, Christiane Klec, Oleksandra Tiapko, Klaus Groschner
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Chemical Science
Chemical Science. 2019;10(9):2837-2842
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Chemical Science
Chemical Science. 2019;10(9):2837-2842
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
A new photochromic ligand enables high precision control over native TRPC channels.
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cel
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdb537dc07b88e6daf6bb2687e07592
Autor:
Rajesh Bhardwaj, Jean-Louis Reymond, Matthias A. Hediger, Christoph Romanin, Carmen Butorac, Micael Rodrigues Cunha, Sonja Lindinger
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By surveying analogs of a previously r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68698cae50bd1c86eb9ddb7009b96282